Silvio O. Conte Center for Oxytocin and Social Cognition

西尔维奥·孔特催产素和社会认知中心

• 批准号: 8476497
• 负责人: Larry J Young
• 金额: $ 198.35万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8476497
• 关键词: Affect; Amygdaloid structure; Animals; Area; Attention; Autoradiography; Brain; Brain region; Clinical; Clinical Ethics; Clinical Trials; Cognitive; Communities; Complex; Consultations; Cues; Data; Development; Disease; Education and Outreach; Electrophysiology (science); Emotions; Environment; Ethics; Eye; Face; Faculty; Functional Magnetic Resonance Imaging; Future; Goals; Health Services Research; Histology; Human; Human Resources; Individual; Interdisciplinary Study; Intranasal Administration; Learning; Ligands; Macaca mulatta; Maps; Mediating; Mental Health; Mental disorders; Nature; Neurons; Neurosciences; Oxytocin; Oxytocin Receptor; Participant; Peripheral; Phenotype; Positron-Emission Tomography; Primates; Principal Investigator; Rattus; Relative (related person); Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Rewards; Rodent; Schools; Science; Scientist; Series; Services; Social Behavior; Social Functioning; Social Interaction; Social Perception; Social Values; Stimulus; System; Techniques; Testing; Therapeutic; Time; Training; Training Activity; Training Programs; autism spectrum disorder; base; drug development; experience; forging; high school; human subject; improved; in vivo; information processing; interdisciplinary approach; lectures; meetings; neurochemistry; neuromechanism; novel; novel strategies; outreach; prairie vole; programs; public health relevance; receptor expression; relating to nervous system; response; social; social attachment; social cognition; tool; undergraduate research; web site

DESCRIPTION (provided by applicant): The oxytocin (OT) system is arguably the most viable target for pharmacologically enhancing social cognition in psychiatric disorders with compromised social cognition, including autism spectrum disorder (ASD). Central OT enhances key aspects of social behavior in animals, and intranasal (IN) OT modulates social cognition in humans. The mechanisms by which OT affects social cognition are not understood. We will launch a coordinated, interdisciplinary research program involving an outstanding team of investigators to test the hypothesis that OT enhances social cognition by increasing the salience and reinforcing value of social stimuli by modulating activity and functional connectivity of the amygdala and brain regions involved in reward. Project scientists will use cutting edge techniques to assess functional connectivity between brain regions during social interactions, responses of individual neurons in the amygdala to social stimuli, or social cognition in animals and humans. Projects 1 and 2 will use in vivo electrophysiology to examine the impact of OT on the neural representation of social stimuli in rodents and rhesus macaques. Project 3 will use cognitive tests to examine the impact of OT on social perception and social attunement in the primate. Project 4 will use cognitive testing and fMRI to examine the impact of OT on social cognition and neural activity in healthy and autistic humans. A Neurochemistry Core will provide vital services for the research projects and develop new tools for characterizing OT receptor expression in the brain. An Administrative Core will coordinate all Center related activities (seminar series, organizing meetings), will provide statistical consultation and coordinate outreach and training activities of Center personnel by strengthening existing relationships and forging new relationships with numerous organizations in the Atlanta area. As a result, the Center will create vibrant collaborative research, training and outreach environment that will have a national impact on mental health research. The data collected by Center faculty will have important translational implications that will directly impact novel strategies for pharmacologically treating social deficits in psychiatric disorders.

描述（由申请人提供）：催产素（OT）系统可以说是具有损害社会认知的精神疾病的药理增强社会认知的最可行的目标，包括自闭症谱系障碍（ASD）。中心OT增强了动物社会行为的关键方面，鼻内（IN）OT可调节人类的社会认知。尚不理解OT影响社会认知的机制。我们将启动一个协调的跨学科研究计划，涉及一个杰出的研究人员团队，以测试以下假设，即OT通过调节杏仁核和大脑区域的活动和功能连通性来提高社会刺激的显着性和增强社会刺激价值，从而增强社会认知。项目科学家将使用尖端技术来评估社交互动期间大脑区域之间的功能连通性，杏仁核对社会刺激的单个神经元的反应或动物和人类的社会认知。项目1和2将使用体内电生理学来检查OT对啮齿动物和恒河猕猴中社会刺激的神经表示的影响。项目3将使用认知测试来检查OT对灵长类动物中社会感知和社会调整的影响。项目4将使用认知测试和fMRI来检查OT对健康和自闭症人类社会认知和神经活动的影响。神经化学核心将为研究项目提供重要服务，并开发新的工具来表征大脑中OT受体表达。行政核心将通过加强与亚特兰大地区的众多组织建立新的关系并建立新的关系，协调所有中心相关活动（研讨会系列，组织会议），将提供统计咨询和协调中心人员的培训和培训活动。结果，该中心将创建充满活力的合作研究，培训和外展环境，这将对心理健康研究产生全国影响。中心教师收集的数据将具有重要的翻译意义，这将直接影响药理治疗精神疾病中社会缺陷的新型策略。