Peromyscus Laboratory Models for Biomedical Research

用于生物医学研究的 Peromyscus 实验室模型

基本信息

批准号：
7373511
负责人：
Michael Ray Felder
金额：
$ 19.38万
依托单位：
UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-07-01 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7373511
关键词：
American Area Attention Babesiosis Basic Science Behavior Biological Preservation Biology Biomedical Research Bioterrorism Breeding Chromosome Mapping Chromosome Painting Communicable Diseases Count Cryopreservation Databases Deer Mouse Development Disease Ehrlichiosis Embryo Transfer Emerging Communicable Diseases Epidemiology Facility Construction Funding Category Figs - dietary Fluorescent in Situ Hybridization Funding Genetic Genomic Imprinting Genomics Habitats Hantavirus House mice Human Hybrids Internet Investigation Laboratories Laboratory mice Lyme Disease Mammals Modeling Molecular Cytogenetics Movement Disorders Mus North America Peromyscus Phylogenetic Analysis Physiological Physiology Plague Positioning Attribute Process Publications Range Rattus Rattus norvegicus Research Research Personnel Resources Rest Rodent Role Social Behavior Source Study models Support of Research Syndrome Technology United States White-Footed Mouse Xenobiotic Metabolism base environmental toxicology genetic technology improved microorganism mortality mutant pathogen positional cloning sperm cell

项目摘要

The Peromyscus Genetic Stock Center is a unique facility. The Stock Center is unmatched for its role as a reliable source of disease free peromyscines, and unmatched for the variety of Peromyscus species and mutants available. The Stock Center is utilized by researchers in a wide range of fields, including human infectious disease. Peromyscines came to the Nation's attention in recent years for their role as the primary reservoir of two emerging infectious disease microorganisms. One of these, hantavirus, causes a disease with near 40% mortality, and is on the list of potential bioterrorism agents. The other one is the etiological agent of Lyme disease, a debilitating disease which counts 15,000 new cases annually. Stock Center resources are used extensively by investigators studying these and other diseases such as Ehrlichiosis, babesiosis and plague. Other research areas benefiting from Stock Center resources include the mechanism and cure of repetitive movement disorders, the genetics of disrupted genomic imprinting, the physiological basis of social behavior, and environmental toxicology. To continue supporting these research endeavors the Stock Center proposes: 1) to continue providing peromyscines for biomedical and related research, 2) to promote the species and its advantages, and 3) to improve the usefulness of Peromyscus as a laboratory model. Funds are requested to enable development of the sperm cryopreservation technology to provide a more economical means of storing some of the rare mutants maintained by the Stock Center. Funds are also requested to support the construction of a Peromyscus genomics database, and to use fluorescence in situ hybridization to globally determine regions of homology between Mus and Peromyscus, thereby expediting development of a linkage map.

佩罗米斯库斯遗传库存中心是一个独特的设施。股票中心的作用是无与伦比的无病 Peromyscines 的可靠来源，并且 Peromyscus 物种的多样性是无与伦比的可用突变体。库存中心被各个领域的研究人员所利用，包括人类传染病。近年来，Peromyscines 因其作为两种新出现的传染病微生物的主要储存库。其中一种，汉坦病毒，会导致这种疾病的死亡率接近 40%，并且被列入潜在的生物恐怖分子名单。另一个是莱姆病是一种使人衰弱的疾病，每年新增病例达 15,000 例。库存研究这些疾病和其他疾病的研究人员广泛使用中心资源，例如埃利希体病、巴贝斯虫病和鼠疫。受益于库存中心资源的其他研究领域包括重复性运动障碍的机制和治疗、基因组印记破坏的遗传学、社会行为的生理基础和环境毒理学。继续支持这些研究库存中心的努力建议：1）继续为生物医学及相关领域提供peromyscines 研究，2) 推广该物种及其优势，以及 3) 提高 Peromyscus 作为实验室模型。需要资金来开发精子冷冻保存技术，以提供更多储存由库存中心维护的一些稀有突变体的经济手段。资金还有请求支持Peromyscus基因组数据库的构建，并使用原位荧光杂交以全局确定Mus和Peromyscus之间的同源区域，从而加快建立联系图。