Peromyscus Laboratory Models for Biomedical Research

用于生物医学研究的 Peromyscus 实验室模型

基本信息

批准号：
7217241
负责人：
Michael Ray Felder
金额：
$ 19.77万
依托单位：
UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-07-01 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7217241
关键词：
American Area Attention Babesiosis Basic Science Behavior Biological Preservation Biology Biomedical Research Bioterrorism Breeding Chromosome Mapping Chromosome Painting Communicable Diseases Count Cryopreservation Databases Deer Mouse Development Disease Ehrlichiosis Embryo Transfer Emerging Communicable Diseases Epidemiology Facility Construction Funding Category Figs - dietary Fluorescent in Situ Hybridization Funding Genetic Genomic Imprinting Genomics Habitats Hantavirus House mice Human Hybrids Internet Investigation Laboratories Laboratory mice Lyme Disease Mammals Modeling Molecular Cytogenetics Movement Disorders Mus North America Peromyscus Phylogenetic Analysis Physiological Physiology Plague Positioning Attribute Process Publications Range Rattus Rattus norvegicus Research Research Personnel Resources Rest Rodent Role Social Behavior Source Study models Support of Research Syndrome Technology United States White-Footed Mouse Xenobiotic Metabolism base environmental toxicology genetic technology improved microorganism mortality mutant pathogen positional cloning sperm cell

项目摘要

DESCRIPTION (provided by applicant): The Peromyscus Genetic Stock Center is a unique facility. The Stock Center is unmatched for its role as a reliable source of disease free peromyscines, and unmatched for the variety of Peromyscus species and mutants available. The Stock Center is utilized by researchers in a wide range of fields, including human infectious disease. Peromyscines came to the Nation's attention in recent years for their role as the primary reservoir of two emerging infectious disease microorganisms. One of these, hantavirus, causes a disease with near 40% mortality, and is on the list of potential bioterrorism agents. The other one is the etiological agent of Lyme disease, a debilitating disease which counts 15,000 new cases annually. Stock Center resources are used extensively by investigators studying these and other diseases such as Ehrlichiosis, babesiosis and plague. Other research areas benefiting from Stock Center resources include the mechanism and cure of repetitive movement disorders, the genetics of disrupted genomic imprinting, the physiological basis of social behavior, and environmental toxicology. To continue supporting these research endeavors the Stock Center proposes: 1) to continue providing peromyscines for biomedical and related research, 2) to promote the species and its advantages, and 3) to improve the usefulness of Peromyscus as a laboratory model. Funds are requested to enable development of the sperm cryopreservation technology to provide a more economical means of storing some of the rare mutants maintained by the Stock Center. Funds are also requested to support the construction of a Peromyscus genomics database, and to use fluorescence in situ hybridization to globally determine regions of homology between Mus and Peromyscus, thereby expediting development of a linkage map.

描述（由申请人提供）：佩罗米斯库斯遗传库存中心是一个独特的设施。该库存中心作为无病披霉素的可靠来源，其作用是无与伦比的，并且其可用的披霉素物种和突变体的多样性也是无与伦比的。库存中心被包括人类传染病在内的多个领域的研究人员所利用。近年来，Peromyscines因其作为两种新兴传染病微生物的主要储存库的作用而引起了国家的关注。其中一种汉坦病毒引起的疾病死亡率接近 40%，并且被列入潜在的生物恐怖分子名单中。另一种是莱姆病的病原体，莱姆病是一种使人衰弱的疾病，每年新增病例 15,000 例。研究人员广泛使用库存中心的资源来研究这些疾病以及埃利希体病、巴贝斯虫病和鼠疫等其他疾病。受益于股票中心资源的其他研究领域包括重复性运动障碍的机制和治疗、基因组印记破坏的遗传学、社会行为的生理基础和环境毒理学。为了继续支持这些研究工作，Stock Center 建议：1) 继续为生物医学和相关研究提供 Peromyscine，2) 推广该物种及其优势，3) 提高 Peromyscus 作为实验室模型的实用性。需要资金来开发精子冷冻保存技术，以提供一种更经济的方式来存储由库存中心维护的一些稀有突变体。还要求资金支持白鼠基因组数据库的建设，并利用荧光原位杂交技术在全球范围内确定小鼠和白鼠之间的同源区域，从而加快连锁图谱的开发。