Core Laboratory for Neuromolecular Production

神经分子生产核心实验室

基本信息

批准号：
7674153
负责人：
charles mark thompson
金额：
$ 47.74万
依托单位：
UNIVERSITY OF MONTANA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-01 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7674153
关键词：
Abbreviations Address Archives Award Centers of Research Excellence Central Nervous System Diseases Chemistry Collaborations Commit Computer Simulation Consultations Core Facility Data Databases Development Ensure Environment Faculty Goals Health Occupations Health Professional Histology Human Resources Image Improve Access Individual Investigation Investments Isotopes Label Laboratories Libraries Ligands Mass Spectrum Analysis Molecular Molecular Computations Montana Neurosciences Neurotransmitters Pharmaceutical Preparations Pharmacology Positioning Attribute Preparation Problem Solving Production Proteins Proteomics Public Health Quality Control Range Reagent Request for Applications Research Research Personnel Resources Science Services Spectrum Analysis Structure Training Universities Work base cheminformatics college concept cost design experience imaging probe neurochemistry peptide structure programs repository scale up small molecule tool

项目摘要

This application will establish a Core Laboratory in Neuromolecular Production (CLNP) that provides neuroscience researchers with customized small molecule tools, consultation, resources and support to assist and advance their investigations. The Core Laboratory in Neuromolecular Production will establish and maintain essential chemistry support for neuroscience investigators including the preparation, optimization, purification and/or separation of small molecule reagents, probes and/or targets that are focused on neurotransmitter-based structures. The CLNP will undertake the synthesis of bioactive ligands, cross-linkers, isotope enriched structures, peptides, structure and imagine probes, protein-tags and bioconjugates, library development (target- and diversity-oriented syntheses), and other molecular ensembles. The CLNP will be achieved with the addition of new space, creation of a dedicated CLNP lab and program suite, a teamwork-oriented administration, workgroup-based problem solving, integration with existing cores, and the hiring of highly trained chemistry personnel to design, maintain, and execute the requested projects and services. The long-range objectives are to advance the CLNP as a dependable and sustainable service and resource to neuroscience investigators that introduces small molecule archives (warehouse) and chemoinformatic databases capable of generating new research avenues. The specific aims of this application are to: (1) design, build, and launch a Core Laboratory in Neuromolecular Production, (2) provide neuroscience investigators with customized neurotransmitter-based, ligands, probes, bioconjugates and resources to aid and enhance their existing, pending and planned NINDS-based research programs, (3) develop workgroups that promote collaborations and multi-laboratory problem solving using neurotransmitter-based ligands, probes and bioconjugates, and (4) create, manage and disseminate for public use a cheminformatic database and repository of neurotransmitter-based ligands, probes and bioconjugates. Public Health Relevance: This application seeks to develop a facility that provides customized small molecules to neuroscientists. Small molecule development is an essential first step toward developing drugs that may be helpful in battling CNS diseases.

该应用程序将建立一个神经分子生产核心实验室（CLNP），提供为神经科学研究人员提供定制的小分子工具、咨询、资源和支持协助并推进他们的调查。神经分子生产核心实验室将建立并为神经科学研究人员提供必要的化学支持，包括准备、小分子试剂、探针和/或靶标的优化、纯化和/或分离专注于基于神经递质的结构。 CLNP将承担生物活性配体的合成，交联剂、同位素富集结构、肽、结构和图像探针、蛋白质标签和生物共轭物、文库开发（目标和多样性导向的合成）和其他分子合奏团。 CLNP 将通过增加新空间、创建专门的 CLNP 实验室来实现和程序套件、面向团队合作的管理、基于工作组的问题解决、与现有的核心，并雇用训练有素的化学人员来设计、维护和执行请求的项目和服务。长期目标是推动 CLNP 成为一个可靠且长期的为神经科学研究人员提供引入小分子档案的可持续服务和资源（仓库）和化学信息学数据库能够产生新的研究途径。具体的该应用程序的目标是：(1) 设计、建立和启动神经分子生产核心实验室， (2) 为神经科学研究人员提供定制的基于神经递质的配体、探针、生物共轭物和资源，以帮助和加强现有的、待定的和计划的基于 NINDS 的研究计划，(3) 建立工作组，促进合作和多实验室问题解决，使用基于神经递质的配体、探针和生物共轭物，以及 (4) 创建、管理和传播公众使用化学信息学数据库和基于神经递质的配体、探针和存储库生物共轭物。公共卫生相关性：该应用程序旨在开发一种设施，提供定制的小型神经科学家的分子。小分子开发是药物开发的重要第一步这可能有助于对抗中枢神经系统疾病。