Core Laboratory for Neuromolecular Production

神经分子生产核心实验室

基本信息

批准号：
7434671
负责人：
charles mark thompson
金额：
$ 63.86万
依托单位：
UNIVERSITY OF MONTANA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-01 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7434671
关键词：
Core Laboratory Neuromolecular Production

项目摘要

DESCRIPTION (provided by applicant): This application will establish a Core Laboratory in Neuromolecular Production (CLNP) that provides neuroscience researchers with customized small molecule tools, consultation, resources and support to assist and advance their investigations. The Core Laboratory in Neuromolecular Production will establish and maintain essential chemistry support for neuroscience investigators including the preparation, optimization, purification and/or separation of small molecule reagents, probes and/or targets that are focused on neurotransmitter-based structures. The CLNP will undertake the synthesis of bioactive ligands, cross-linkers, isotope enriched structures, peptides, structure and imagine probes, protein-tags and bioconjugates, library development (target- and diversity-oriented syntheses), and other molecular ensembles. The CLNP will be achieved with the addition of new space, creation of a dedicated CLNP lab and program suite, a teamwork-oriented administration, workgroup-based problem solving, integration with existing cores, and the hiring of highly trained chemistry personnel to design, maintain, and execute the requested projects and services. The long-range objectives are to advance the CLNP as a dependable and sustainable service and resource to neuroscience investigators that introduces small molecule archives (warehouse) and chemoinformatic databases capable of generating new research avenues. The specific aims of this application are to: (1) design, build, and launch a Core Laboratory in Neuromolecular Production, (2) provide neuroscience investigators with customized neurotransmitter-based, ligands, probes, bioconjugates and resources to aid and enhance their existing, pending and planned NINDS-based research programs, (3) develop workgroups that promote collaborations and multi-laboratory problem solving using neurotransmitter-based ligands, probes and bioconjugates, and (4) create, manage and disseminate for public use a cheminformatic database and repository of neurotransmitter-based ligands, probes and bioconjugates.

描述（由申请人提供）：本申请将建立神经分子生产（CLNP）的核心实验室，该实验室为神经科学研究人员提供定制的小分子工具，咨询，资源和支持，以协助和进步他们的研究。神经分子产生的核心实验室将为神经科学研究者建立和维持基本的化学支持，包括小分子试剂，探针和/或靶标的制备，优化，纯化和/或分离，这些试剂，探针和/或靶标都集中在基于神经递质的结构上。 CLNP将承担生物活性配体，交联，同位素富含结构，肽，结构和想象探针，蛋白质标签和生物缀合物，图书馆发展（目标和多样性的合成）以及其他分子结合物的合成。通过增加新空间，创建专用的CLNP实验室和计划套件，面向团队工作的管理，基于工作组的问题解决，与现有核心的集成以及雇用受过良好培训的化学人员来设计，维护和执行所需的项目和服务，可以实现CLNP。远程目标是将CLNP作为可靠，可持续的服务和资源推进神经科学研究人员，该研究人员介绍了小分子档案（仓库）和能够生成新的研究途径的化学信息数据库。该应用程序的具体目的是：（1）设计，建立和启动神经分子生产中的核心实验室（2）为神经科学研究人员提供基于自定义的神经递质，配体，探针，探针，生物缀合物和资源，以帮助和增强基于Ninds的研究程序，并促进其综合工作集，（3）促进工作组，（3），（3）基于神经递质的配体，探针和生物缀合物，以及（4）创建，管理和传播用于公共的使用化学信息数据库和基于神经递质的配体，探针和生物缀合物的储存库。