Neuropathologic research on dementia using Nun Study and HAAS data

使用 Nun 研究和 HAAS 数据进行痴呆症的神经病理学研究

• 批准号: 8526141
• 负责人: Thomas J Montine
• 金额: $ 62.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8526141
• 关键词: Abbreviations; Address; Adult; Aging; Alzheimer' s Disease; Amyloid beta-Protein; Archives; Area; Asia; Autopsy; Biometry; Brain; Brain imaging; Caliber; Cerebrovascular Trauma; Cessation of life; Clinical Research; Cognitive; Communities; Consensus; Data; Data Set; Dementia; Demography; Development; Disease; Education; Elderly; Epidemiology; Etiology; Evaluation; Foundations; Functional disorder; Future; Glial Fibrillary Acidic Protein; Gliosis; Health; Image; Impaired cognition; Individual; Injury; Knowledge; Laboratories; Lesion; Lewy Bodies; Lewy Body Disease; Life; Measurement; Measures; Methods; Minnesota; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Nerve Degeneration; Neurofibrillary Tangles; Pathogenesis; Pathologic Processes; Process; Publishing; Registries; Research; Research Infrastructure; Resources; Risk; Risk Factors; Role; Scientist; Senile Plaques; Testing; United States National Institutes of Health; Universities; Validation; Washington; aging brain; astrogliosis; base; cerebral atrophy; cognitive function; cohort; community setting; comparative; data sharing; instrument; mental state; mild cognitive impairment; neuroimaging; pre-clinical; prevent; public health relevance; response to injury; screening; therapeutic development; tool; white matter

DESCRIPTION (provided by applicant): The development of strategies to prevent Alzheimer's disease (AD) and related dementing illnesses will depend on an understanding of the underlying pathologic processes. In recent years it has become apparent that in older persons, these illnesses are usually the result of two or more fundamental pathogenic processes, often interacting additively. This complexity has been recognized largely as a result of neuropathological research in the context of longitudinal epidemiologic projects such as the Nun Study and the Honolulu-Asia Aging Study (HAAS), both now completed. The proposed project will compile accrued data and images from 854 HAAS autopsies and approximately 500 Nun Study autopsies, develop a common dataset and archive of photographic images of brain sections, and will be employed in parallel assessments of newly revised neuropathologic criteria for the identification and measurement of the AD disease process, which will be compared to previous criteria. In addition, these same data will be utilized for in an in-depth analysis of the interdependent and independent roles of AD brain lesions and brain atrophy as proximate causal factors responsible for dementia. These efforts are expected to: (1) provide a foundation for future analytic use of the accrued resources of the two projects, (2) examine the likely impact and utility of the revised neuropathologic AD assessment criteria for future research addressing the dementing illnesses of late life, and (3) facilitate a conceptual convergence of our understanding of the causes and importance of brain atrophy from neuroimaging and neuropathological perspectives.

描述（由申请人提供）：预防阿尔茨海默氏病（AD）和相关痴呆疾病的策略的制定将取决于对基本病理过程的理解。近年来，很明显，在老年人中，这些疾病通常是两个或多个基本的致病过程的结果，通常是加性相互作用的。在纵向流行病学项目（例如Nun nun研究和檀香山 - 亚洲衰老研究（HAAS））的背景下，由于神经病理学研究（HAAS），这一复杂性在很大程度上得到了认可。拟议的项目将编写来自854个HAAS尸检的应计数据和图像，并大约500个Nun研究尸检，开发一个常见的数据集和脑部摄影图像的档案，并将用于对新修订的神经病理学标准的并行评估，以与先前的cretia相比，将其用于AD病疾病过程的识别和测量。此外，这些相同的数据将用于对 AD脑病变和脑萎缩的相互依存和独立作用是负责痴呆症的近端因素。这些努力应：（1）为将来的两个项目的应计资源分析提供基础，（2）检查可能的影响 以及修订后的神经病理AD评估标准的实用性，用于未来研究，以解决后期疾病的痴呆疾病，（3）促进我们从神经影像学和神经病理学的角度来理解脑萎缩的原因和重要性的概念融合。