Neuropathologic research on dementia using Nun Study and HAAS data

使用 Nun 研究和 HAAS 数据进行痴呆症的神经病理学研究

• 批准号: 8526141
• 负责人: Thomas J Montine
• 金额: $ 62.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8526141
• 关键词: Abbreviations; Address; Adult; Aging; Alzheimer' s Disease; Amyloid beta-Protein; Archives; Area; Asia; Autopsy; Biometry; Brain; Brain imaging; Caliber; Cerebrovascular Trauma; Cessation of life; Clinical Research; Cognitive; Communities; Consensus; Data; Data Set; Dementia; Demography; Development; Disease; Education; Elderly; Epidemiology; Etiology; Evaluation; Foundations; Functional disorder; Future; Glial Fibrillary Acidic Protein; Gliosis; Health; Image; Impaired cognition; Individual; Injury; Knowledge; Laboratories; Lesion; Lewy Bodies; Lewy Body Disease; Life; Measurement; Measures; Methods; Minnesota; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Nerve Degeneration; Neurofibrillary Tangles; Pathogenesis; Pathologic Processes; Process; Publishing; Registries; Research; Research Infrastructure; Resources; Risk; Risk Factors; Role; Scientist; Senile Plaques; Testing; United States National Institutes of Health; Universities; Validation; Washington; aging brain; astrogliosis; base; cerebral atrophy; cognitive function; cohort; community setting; comparative; data sharing; instrument; mental state; mild cognitive impairment; neuroimaging; pre-clinical; prevent; public health relevance; response to injury; screening; therapeutic development; tool; white matter

DESCRIPTION (provided by applicant): The development of strategies to prevent Alzheimer's disease (AD) and related dementing illnesses will depend on an understanding of the underlying pathologic processes. In recent years it has become apparent that in older persons, these illnesses are usually the result of two or more fundamental pathogenic processes, often interacting additively. This complexity has been recognized largely as a result of neuropathological research in the context of longitudinal epidemiologic projects such as the Nun Study and the Honolulu-Asia Aging Study (HAAS), both now completed. The proposed project will compile accrued data and images from 854 HAAS autopsies and approximately 500 Nun Study autopsies, develop a common dataset and archive of photographic images of brain sections, and will be employed in parallel assessments of newly revised neuropathologic criteria for the identification and measurement of the AD disease process, which will be compared to previous criteria. In addition, these same data will be utilized for in an in-depth analysis of the interdependent and independent roles of AD brain lesions and brain atrophy as proximate causal factors responsible for dementia. These efforts are expected to: (1) provide a foundation for future analytic use of the accrued resources of the two projects, (2) examine the likely impact and utility of the revised neuropathologic AD assessment criteria for future research addressing the dementing illnesses of late life, and (3) facilitate a conceptual convergence of our understanding of the causes and importance of brain atrophy from neuroimaging and neuropathological perspectives.

描述（由申请人提供）：预防阿尔茨海默病（AD）和相关痴呆症的策略的制定将取决于对潜在病理过程的理解。近年来，越来越明显的是，在老年人中，这些疾病通常是两种或多种基本致病过程的结果，并且常常相互作用。人们认识到这种复杂性很大程度上是纵向流行病学项目中神经病理学研究的结果，例如修女研究和檀香山亚洲老龄化研究（HAAS），这两项研究现已完成。拟议的项目将编译来自 854 份 HAAS 尸检和大约 500 份 Nun Study 尸检的累积数据和图像，开发脑切片摄影图像的通用数据集和档案，并将用于新修订的神经病理学标准的并行评估，以进行识别和测量AD 疾病过程的详细信息，将与之前的标准进行比较。此外，这些相同的数据将用于深入分析 AD 脑损伤和脑萎缩作为导致痴呆的直接原因，具有相互依赖和独立的作用。这些努力预计将：(1) 为未来分析使用这两个项目所积累的资源奠定基础，(2) 检查可能的影响 以及修订后的神经病理学 AD 评估标准在解决晚年痴呆症的未来研究中的实用性，(3) 促进我们从神经影像学和神经病理学角度理解脑萎缩的原因和重要性的概念趋同。