Neuropathology Core

神经病理学核心

• 批准号: 10176345
• 负责人: Thomas J Montine
• 金额: $ 40.89万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10176345
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Autopsy; Award; Biological Assay; Biological Markers; Brain; Brain region; Clinical Data; Cognitive; Consensus; Country; Data; Dementia; Development; Diagnostic; Discipline; Disease; Environment; Evaluation; Faculty; Formalin; Fostering; Freezing; Future; Guidelines; Image; Impaired cognition; Individual; Interdisciplinary Study; International; Leadership; Medical Students; Methods; Mission; Molecular; Nerve Degeneration; Neurodegenerative Disorders; Outreach Research; Paraffin Embedding; Pathologic; Pathologic Processes; Patients; Physicians; Positioning Attribute; Process; Reporting; Research; Research Personnel; Resource Sharing; Scientist; Specimen; Structure; Techniques; Technology; Time; Tissue Embedding; Tissues; Training; Translational Research; Vision; aging brain; biobank; brain research; brain tissue; data management; data quality; education research; graduate student; imaging approach; innovation; innovative technologies; insight; molecular pathology; neuropathology; repository; research study; statistics

1. SUMMARY (Neuropathology Core) The Neuropathology Core supports the vision of the Stanford Alzheimer’s Disease Center (ADRC) to serve as a shared resource to facilitate and enhance multidisciplinary and interdisciplinary research in Alzheimer’s disease (AD) and related disorders. The Core is structured to continue its track record of enabling and applying innovative cutting-edge technologies with emphasis on brain aging and the diversity of pathologic processes that underlie cognitive impairment and dementia caused by AD and related diseases. The critical functions of the Neuropathology Core include diagnostic expertise, serving as a biorepository, facilitating innovation, and training. Over the past five years, the Neuropathology Core has completed over 50 research brain autopsies and held a leadership position in setting and evaluating national research guidelines for neuropathologic evaluation of AD. We have banked over 800 tissue specimens, contributed data and biospecimens to local, regional, national, and international research studies and consortia, and fostered development and implementation of innovative technologies in translational research. Through the Core, we trained clinicians and scientists from different disciplines in neuropathology and the molecular pathology of dementia-related neurodegenerative diseases. The Neuropathology Core will pursue its mission through four Specific Aims. The Core will provide comprehensive neuropathologic evaluations for physicians and researchers with timely and comprehensive autopsy reports that describe the neuropathologic features of AD and related diseases according to the most current guidelines and consensus diagnostic criteria. It will maintain and continue to grow its highly accessible, but appropriately safeguarded, repository of brain tissue and biospecimens from carefully and longitudinally characterized patients with cognitive impairment or dementia, as well as cognitively normal individuals, using methods that increase and maximize tissue and data quality. In doing so, the Core will empower innovative high-content imaging approaches for both formalin-fixed, paraffin-embedded tissue and for frozen brain regions to maximize the research value of the Stanford ADRC repository and other brain banks around the country. Finally, we will maintain a rich training environment for medical and graduate students, residents, fellows, and junior faculty across departments to teach concepts and state-of-the-art techniques that advance current interdisciplinary research and foster future advances and insights in brain aging and neurodegeneration. The Core is organized to maximize integration with all other Cores in the Stanford ADRC. It also will continue to serve as a hub of support for affiliated ADRCs and independent research awards through diagnostic practices, molecular assays, and tissue sharing. In doing so, the Core and Center will continue to contribute nationally to advance our understanding of the pathologic features and pathophysiologic processes of brain aging, all stages of AD, and related dementias.

1。摘要（神经病理学核心） 神经病理学核心支持斯坦福大学阿尔茨海默氏病（ADRC）的愿景 共享资源，可促进和增强阿尔茨海默氏症的多学科和跨学科研究 疾病（AD）和相关疾病。核心的结构是继续其启用和应用的记录 创新的尖端技术，重点是大脑衰老和病理过程的多样性 这是由AD和相关疾病引起的认知障碍和痴呆症的基础。关键功能 神经病理学核心包括诊断专业知识，作为生物座席，支持创新和 训练。在过去的五年中，神经病理学核心已完成50多个研究脑尸检 并在设定和评估国家神经病理学的国家研究指南方面拥有领导地位 AD评估。我们已经将超过800个组织标本融为一 区域，国家和国际研究和财团，并促进了发展和 在翻译研究中实施创新技术。通过核心，我们训练了临床医生 来自神经病理学不同学科的科学家以及与痴呆有关的分子病理学 神经退行性疾病。神经病理学核心将通过四个特定目标来追求其使命。 核心将为医生和研究人员及时提供全面的神经病理评估 综合尸检报告描述了广告和相关疾病的神经病理特征 根据最新的指南和共识诊断标准。它将维护并继续 从 仔细而纵向的认知障碍或痴呆症患者以及认知的患者 正常人，使用增加和最大化组织和数据质量的方法。这样，核心 将赋予福尔马林固定的石蜡包裹的组织的创新高含量成像方法 并使冻结的大脑区域最大化Stanford ADRC存储库和其他大脑的研究价值 全国各地的银行。最后，我们将维持医学和毕业生的丰富培训环境 各个部门的学生，居民，研究员和初级教师教授概念和最先进的教师 推进当前跨学科研究并促进大脑未来进步和见解的技术 衰老和神经变性。核心的组织以最大化与所有其他核心的集成 斯坦福德·阿德里克（Stanford Adrc）。它还将继续作为对会员ADRC和独立的支持的枢纽 通过诊断实践，分子评估和组织共享进行研究奖励。这样，核心和 中心将继续在全国范围内做出贡献，以促进我们对病理特征和 大脑衰老的病理生理过程，AD的所有阶段和相关痴呆症。