Neuropathology Core

神经病理学核心

• 批准号: 10601059
• 负责人: Thomas J Montine
• 金额: $ 27.05万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601059
• 关键词: Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease patient; Archives; Autopsy; Biological Assay; Biological Markers; Blood; Blood Vessels; Board Certification; Brain; Brain region; Caring; Cataloging; Catalogs; Cell Line; Cells; Cellular biology; Cessation of life; Clinical; Clinical Data; Collaborations; Collection; Communication; Country; DNA; Data; Dementia; Diagnosis; Diagnostic; Disease Progression; Elderly; Elements; Enrollment; Ensure; Evaluation; Family; Freezing; Genetic; Genomics; Goals; Individual; International; Internet; Leadership; Lewy Bodies; Life; Link; Memory; Mission; Molecular; Molecular Analysis; Monitor; Morphology; Neurosciences; Participant; Pathologic; Pathology; Patients; Process; Proteomics; Qualifying; Registries; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Sampling; Services; Specimen; Stem Cell Research; Technology; Time; Tissue Banks; Tissues; Training; Translational Research; Universities; Veins; Wisconsin; blood product; cell bank; cell repository; cohort; data management; experience; induced pluripotent stem cell; innovation; interest; mild cognitive impairment; neuroimaging; neuropathology; normal aging; novel marker; pre-clinical; programs; protein TDP-43; repository; software development; stem cells; symposium; tissue biomarkers; tissue fixing; tool

PROJECT SUMMARY - NEUROPATHOLOGY CORE (CORE D) The mission of the Neuropathology Core at the Wisconsin Alzheimer's Disease Research Center (ADRC) is to: provide detailed characterization of brains from patients with Alzheimer's disease (AD) and other dementias; facilitate scientific and intellectual interactions between the various ADRC cores; and serve as a local and national repository for AD specimens. The Core will continue to facilitate clinical-pathologic and translational research on normal aging, mild cognitive impairment (MCI), AD, and other dementias by providing to Wisconsin ADRC and outside investigators a comprehensive resource of biospecimens, biomarker data, clinical data, and state-of-the-art diagnoses for MCI and AD, vascular, Lewy body, TDP-43, and mixed pathologies, from subjects in the Clinical Core and Wisconsin Registry for Alzheimer's Prevention (WRAP). The Neuropathology Core will generate and assemble critical diagnostic information by combining clinical data (Core B), innovative neuroimaging and biomarker assays (Core G) collected during life with brain autopsy, and morphologic, immunohistochemical, genetic, cell and molecular post-mortem analyses. The Neuropathology Core will also provide access to cutting edge tools (including genomics and proteomics) to enhance AD research on banked, frozen tissue. Additionally, the Core has taken a leadership role in setting up an induced pluripotent stem cells (iPSC) bank, with the aim of providing well-characterized stem cell lines from AD and control patients to investigators throughout the country. The Core will accomplish these goals by 1) collecting and archiving post- mortem frozen and fixed tissue blocks from multiple brain regions on deceased individuals, and ante-mortem CSF, blood, and DNA who are enrolled in the Wisconsin ADRC as well as normal elderly controls; 2) providing state-of-the-art postmortem diagnoses on Clinical Core subjects, collect National Alzheimer's Coordinating Center (NACC) neuropathology data and make the results available to the family, relevant clinicians, qualified researchers, and NACC; 3) distributing ante-mortem and post-mortem biospecimens (brain, CSF, blood products, and DNA) and neuropathologic, genetic, biomarker, and other data to suit the requirements of qualified research projects, both within UW-Madison and for national and international multi-center collaborations; 4) performing genetic and biomarker analyses in support of ADRC and outside investigators; and 5) providing well- characterized iPSC lines to local and national researchers. A flow of services is therefore envisaged whereby Wisconsin ADRC investigators and collaborators are able to obtain unambiguous post-mortem diagnosis, neuropathological data, and tissues from the Neuropathology Core together with comprehensive biomarker data (Biomarker Services) and neuroimaging data (Core G). Finally, the Core will also support advanced molecular and cellular analyses can be performed on tissues by the Biomarker and Cellular and Molecular Neuroscience Services.

项目摘要 - 神经病理学核心（核心D） 威斯康星州阿尔茨海默氏病研究中心（ADRC）的神经病理学核心的使命是： 提供来自阿尔茨海默氏病（AD）和其他痴呆症患者的大脑的详细表征； 促进各种ADRC核心之间的科学和智力互动；并充当本地 广告标本的国家存储库。核心将继续促进临床病理学和翻译 通过向威斯康星州提供正常衰老，轻度认知障碍（MCI），AD和其他痴呆症的研究 ADRC和外部研究人员的生物测量，生物标志物数据，临床数据和 来自受试者的MCI和AD，血管，Lewy身体，TDP-43和混合病理的最新诊断 在阿尔茨海默氏症预防（WARP）的临床核心和威斯康星州注册中。神经病理学核心将 通过组合临床数据（核心B），创新来生成和组装关键诊断信息 神经影像学和生物标志物分析（核心G）在脑尸检和形态学中收集的核心G） 免疫组织化学，遗传，细胞和分子后分析。神经病理学核心也将 提供对最先进工具（包括基因组学和蛋白质组学）的访问，以增强对银行的广告研究， 冷冻组织。此外，核心在建立诱导的多能干细胞方面发挥了领导作用 （IPSC）银行，目的是提供从AD和对照患者进行良好特征的干细胞系 全国各地的调查人员。核心将通过1）收集和归档后实现这些目标 - 验尸从已故个体的多个大脑区域冷冻和固定组织块，而事前 参加威斯康星州ADRC以及正常的老年对照组的CSF，血液和DNA； 2）提供 关于临床核心主题的最先进的验尸诊断，收集国家阿尔茨海默氏症协调 中心（NACC）神经病理学数据，并将结果提供给家族，相关临床医生，合格 研究人员和NACC； 3）分发前验尸和验尸后生物测量（脑，CSF，血液 产品，DNA）以及神经病理学，遗传，生物标志物和其他数据，以满足合格的要求 在大学麦迪逊分校内以及国家和国际多中心合作的研究项目； 4） 进行遗传和生物标志物分析以支持ADRC和外部研究人员； 5）提供良好 将IPSC线条定为本地和国家研究人员。因此，设想了一个服务流 威斯康星州ADRC调查人员和合作者能够获得明确的验尸后诊断， 神经病理学数据和来自神经病理学核心的组织以及全面的生物标志物数据 （生物标志物服务）和神经影像学数据（核心G）。最后，核心还将支持晚期分子 可以通过生物标志物，细胞和分子神经科学对组织进行细胞分析 服务。