Core Laboratory for Neuromolecular Production

神经分子生产核心实验室

基本信息

批准号：
8077435
负责人：
charles mark thompson
金额：
$ 66.12万
依托单位：
UNIVERSITY OF MONTANA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-01 至 2013-11-30
项目状态：
已结题

项目摘要

This application will establish a Core Laboratory in Neuromolecular Production (CLNP) that provides neuroscience researchers with customized small molecule tools, consultation, resources and support to assist and advance their investigations. The Core Laboratory in Neuromolecular Production will establish and maintain essential chemistry support for neuroscience investigators including the preparation, optimization, purification and/or separation of small molecule reagents, probes and/or targets that are focused on neurotransmitter-based structures. The CLNP will undertake the synthesis of bioactive ligands, cross-linkers, isotope enriched structures, peptides, structure and imagine probes, protein-tags and bioconjugates, library development (target- and diversity-oriented syntheses), and other molecular ensembles. The CLNP will be achieved with the addition of new space, creation of a dedicated CLNP lab and program suite, a teamwork-oriented administration, workgroup-based problem solving, integration with existing cores, and the hiring of highly trained chemistry personnel to design, maintain, and execute the requested projects and services. The long-range objectives are to advance the CLNP as a dependable and sustainable service and resource to neuroscience investigators that introduces small molecule archives (warehouse) and chemoinformatic databases capable of generating new research avenues. The specific aims of this application are to: (1) design, build, and launch a Core Laboratory in Neuromolecular Production, (2) provide neuroscience investigators with customized neurotransmitter-based, ligands, probes, bioconjugates and resources to aid and enhance their existing, pending and planned NINDS-based research programs, (3) develop workgroups that promote collaborations and multi-laboratory problem solving using neurotransmitter-based ligands, probes and bioconjugates, and (4) create, manage and disseminate for public use a cheminformatic database and repository of neurotransmitter-based ligands, probes and bioconjugates.

该应用程序将建立一个神经分子生产核心实验室（CLNP），为神经科学研究人员提供定制的小分子工具、咨询、资源和支持，以协助和推进他们的研究。神经分子生产核心实验室将为神经科学研究人员建立和维持必要的化学支持，包括专注于基于神经递质的结构的小分子试剂、探针和/或靶标的制备、优化、纯化和/或分离。 CLNP 将承担生物活性配体、交联剂、同位素富集结构、肽、结构和想象探针、蛋白质标签和生物缀合物的合成、文库开发（面向目标和多样性的合成）以及其他分子组合。 CLNP 将通过增加新空间、创建专门的 CLNP 实验室和程序套件、以团队合作为导向的管理、基于工作组的问题解决、与现有核心的集成以及雇用训练有素的化学人员来设计、维护并执行所请求的项目和服务。长期目标是推动 CLNP 成为神经科学研究人员可靠且可持续的服务和资源，引入能够产生新研究途径的小分子档案（仓库）和化学信息数据库。该应用程序的具体目标是：(1) 设计、建立和启动神经分子生产核心实验室，(2) 为神经科学研究人员提供定制的基于神经递质的配体、探针、生物缀合物和资源，以帮助和增强他们现有的、待定和计划中的基于 NINDS 的研究项目，(3) 建立工作组，利用基于神经递质的配体、探针和生物共轭物促进合作和多实验室问题解决，以及 (4)创建、管理和传播供公众使用的化学信息数据库和基于神经递质的配体、探针和生物共轭物的存储库。