THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE

阿尔茨海默病数据存储站点的 NIA 遗传学

基本信息

批准号：
9524320
负责人：
LI-SAN WANG
金额：
$ 16.1万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-01 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9524320
关键词：
Abbreviations Address Affect Alzheimer&apos s Disease American Archives Cells Cognitive Collection Communities Community Outreach Computer software DNA Sequence Data Data Collection Data Coordinating Center Data Provenance Data Quality Data Set Data Storage and Retrieval Databases Dementia Dependency Deposition Disease Documentation Drug Targeting Educational workshop Ensure Fostering Funding Gene Expression Genes Genetic Genetic Research Genetic study Genomics Genotype Hereditary Disease Human Genetics Imagery Knowledge Late Onset Alzheimer Disease Link Maps Medical Mission National Human Genome Research Institute National Institute on Aging Neurosciences Newsletter Ontology Pathway interactions Patients Phenotype Policies Process Production Publications Research Research Infrastructure Research Personnel Resources Retrieval SNP array Sampling Sequence Alignment Single Nucleotide Polymorphism Site U-Series Cooperative Agreements United States National Institutes of Health Variant data resource data sharing database of Genotypes and Phenotypes design exome gene interaction genetic variant genome sequencing genome wide association study genome-wide genomic data improved insight meetings novel outreach program phenotypic data posters prevent programs repository symposium tool web interface web site whole genome

项目摘要

Project Summary NIA has established the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) as a national genetics data repository in order to facilitate access by qualified investigators to genotypic data for the study of the genetics of late-onset Alzheimer's Disease (AD). It is the policy of the NIA that all Genetic Data derived from NIA funded studies for the genetics of late-onset Alzheimer's disease be deposited at NIAGADS or another NIA approved site or both whenever possible. NIAGADS is also the Data Coordinating Center for Alzheimer's Disease Sequencing Project (ADSP), a White House/NIH initiative to identify new genetic variants by sequencing genomes/exomes of ~15,000 AD patients and cognitively normal controls. In the second funding period, NIAGADS will continue its mission as the national repository for AD genetics with these proposed activities: (1) receive and organize AD genetics datasets for community access, (2) coordinate data production and support analysis activities for ADSP, (3) develop the AD Genomics Information Gateway (AD-GIG), an integrated information platform for researchers to access AD knowledge, data, and other resources at NIAGADS more easily, (4) expand NIAGADS resource by interfacing with other research initiatives, and (5) promote community involvement with an active outreach program.

项目概要 NIA建立了国家老年痴呆症遗传学研究所数据存储站点（NIAGADS）作为国家遗传学数据存储库，以方便合格的研究人员访问用于研究迟发性阿尔茨海默病 (AD) 遗传学的基因型数据。这是NIA的政策来自 NIA 资助的晚发性阿尔茨海默病遗传学研究的所有遗传数据均应尽可能存放在 NIAGADS 或其他 NIA 批准的地点或两者。 NIAGADS 也是数据阿尔茨海默氏病测序项目协调中心 (ADSP)，白宫/NIH 的一项倡议，旨在通过对约 15,000 名认知正常的 AD 患者的基因组/外显子组进行测序，识别新的遗传变异控制。在第二个资助期内，NIAGADS 将继续履行作为 AD 国家存储库的使命遗传学与这些拟议的活动：（1）接收和组织 AD 遗传学数据集以供社区访问， (2) 协调 ADSP 的数据生产和支持分析活动，(3) 开发 AD 基因组学信息网关（AD-GIG），一个供研究人员获取AD知识的综合信息平台，更容易地在 NIAGADS 上获取数据和其他资源，(4) 通过与其他资源连接来扩展 NIAGADS 资源研究举措，(5) 通过积极的外展计划促进社区参与。