CORE B-Data Management, Harmonization, and Information Transfer Core

CORE B-数据管理、协调和信息传输核心

基本信息

批准号：
10388088
负责人：
LI-SAN WANG
金额：
$ 257.72万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-15 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10388088
关键词：
Alzheimer&apos s Disease Alzheimer&apos s Disease Core Center Alzheimer&apos s disease related dementia Automobile Driving Biostatistics Core ChIP-seq Communities Computer software Data Data Analyses Data Files Data Set Deposition Documentation Ensure Environment Genes Genetic Genetic Research Genome Genotype Haplotypes Image Information Dissemination Information Technology Joints Output Pathway Analysis Phase Phenotype Process Production Protocols documentation Quality Control Research Research Personnel Source Source Code Testing Variant Work cloud based cloud platform computer code computer infrastructure computerized data processing data harmonization data management data quality data sharing data storage site design distributed data exome exome sequencing follow-up functional genomics gene interaction genetic variant genome wide association study genomic data in silico insertion/deletion mutation phenotypic data programs repository transcriptome sequencing web site whole genome

项目摘要

Core B Project Summary Core B (Data Management, Harmonization, and Information Transfer Core) is responsible for facilitating analysis of Alzheimer’s Disease Sequence Project (ADSP) data and other relevant projects by processing and harmonizing all relevant genetic and functional genomics (FG) data. Core B will manage all phenotype, genotype, annotation, and analysis results, and distribute data/files to all ADSP investigators and to NIA Genetics of Alzheimer’s Data Storage Site (NIAGADS), the NIA-designated qualified access repository for AD genetics research. Specific Aims are: (1) Receive and manage all relevant genotypic, phenotypic, and functional genomic data; (2) Calling SNVs, indels and structural variants (SVs) from sequencing data; (3) Develop a GCAD haplotype reference panel with GCAD WGS data for GWAS imputation; (4) Facilitate harmonization of FG/omics data by developing best practices for data processing and coordinate harmonization of ADSP FG Program and other relevant omics data; (5) Support GCAD information technology needs and information dissemination activities.

核心B项目总结核心 B（数据管理、协调和信息传输核心）负责促进阿尔茨海默病序列项目 (ADSP) 数据和其他相关数据的分析通过处理和协调所有相关遗传和功能基因组学 (FG) 数据来开展项目。 Core B将管理所有表型、基因型、注释和分析结果，并分发数据/文件发送给所有 ADSP 研究人员和 NIA Genetics of 阿尔茨海默病数据存储站点 (NIAGADS)，NIA 指定的用于 AD 遗传学研究的合格访问存储库。目标是： (1) 接收和管理所有相关的基因型、表型和功能基因组 (2) 从测序数据中调用 SNV、插入缺失和结构变异 (SV)； GCAD 单倍型参考面板，包含用于 GWAS 插补的 GCAD WGS 数据 (4) 促进；通过开发数据处理和分析的最佳实践来协调 FG/组学数据协调 ADSP FG 计划和其他相关组学数据的协调 (5) 支持； GCAD信息技术需求和信息传播活动。