ROLE OF THE BED NUCLEUS IN NORMAL AND GENERALIZED ANXIETY

床核在正常和普遍焦虑中的作用

• 批准号: 7604705
• 负责人: Rudolf Franz Walter Hoehn-Saric
• 金额: $ 0.07万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604705
• 关键词: Amygdaloid structure; Animals; Anxiety; Beds; Brain; Brain region; Cell Nucleus; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Cues; Fright; Functional disorder; Funding; Future; Generalized Anxiety Disorder; Grant; Human; Imaging Techniques; Individual; Institution; Intervention; Knowledge; Methods; Neurobiology; Research; Research Personnel; Resources; Role; Science; Source; Staging; Structure of terminal stria nuclei of preoptic region; Time; United States National Institutes of Health; Universities; human study; member; neuroimaging; novel; psychologic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anxiety manifests itself as a fear, namely a cued anxiety, or in a generalized "free floating" form. Animal and human studies demonstrated the role of the amygdala in the acquisition of cued anxiety. However, recent animal studies suggest that the bed nucleus of the stria terminalis (BNST), rather than the amygdala, is essential in manifestations of uncued anxiety. Therefore, Davis (1) has proposed, that a dysfunction in the BNST may be responsible for generalized anxiety disorder (GAD). The aim of the proposed study is to examine the effects of two anxiety-provoking tasks, one cued and one uncued, on the amygdala and BNST in individuals with GAD and non-anxious controls, using new imaging techniques developed in the Department of Psychological and Brain Sciences at Johns Hopkins University. These novel neuroimaging methods permit, for the first time, analysis of brain activation in extremely small brain regions, such as the BNST. A demonstration that the BNST is, in contrast to the amygdala, more activated by non-cued than cued tasks and more activated in individuals with generalized anxiety would significantly advance our knowledge of the neurobiology of normal and pathological anxiety in humans. Moreover, it would set the stage for future studies to assess the effects of various treatment interventions on BNST activity in pathological anxiety states. Collaboration with members of the Department of Psychological and Brain Sciences at Johns Hopkins University will permit above outlined explorations that may have a significant expansion of our knowledge of the neurobiology of anxiety.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 焦虑表现为恐惧，即暗示性焦虑，或以广义的“自由浮动”形式。动物和人类研究证明了杏仁核在获得暗示焦虑中的作用。然而，最近的动物研究表明，终纹床核（BNST）而不是杏仁核，在无提示焦虑的表现中至关重要。因此，Davis (1) 提出，BNST 功能障碍可能是广泛性焦虑症 (GAD) 的原因。拟议研究的目的是使用心理和健康系开发的新成像技术，检查两种引起焦虑的任务（一种有提示的和一种无提示的）对广泛性焦虑症和非焦虑对照个体的杏仁核和 BNST 的影响。约翰霍普金斯大学脑科学。这些新颖的神经成像方法首次允许分析极小的大脑区域（例如 BNST）的大脑激活。 与杏仁核相比，BNST 更容易被非提示任务激活，并且在患有广泛性焦虑的个体中更被激活，这将显着增进我们对人类正常和病理性焦虑的神经生物学的了解。此外，这将为未来的研究奠定基础，以评估各种治疗干预措施对病理性焦虑状态下 BNST 活动的影响。 与约翰·霍普金斯大学心理和脑科学系成员的合作将允许上述探索，这可能会显着扩展我们对焦虑神经生物学的了解。