THE ROLE OF THE BED NUCLEUS OF THE STRIA TERMINALIS IN GENERALIZED ANXIETY

终纹床核在广泛性焦虑中的作用

• 批准号: 7604709
• 负责人: Rudolf Franz Walter Hoehn-Saric
• 金额: $ 0.07万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604709
• 关键词: Anxiety; Anxiety Disorders; Arousal; Attention; Behavior; Behavioral; Cognitive; Complex; Computer Retrieval of Information on Scientific Projects Database; Condition; Cues; Data; Functional Magnetic Resonance Imaging; Funding; Generalized Anxiety Disorder; Grant; Individual; Institution; Investigation; Learning; Measures; Neurobiology; Patient Self-Report; Patients; Performance; Probability; Process; Psychological reinforcement; Punishment; Reaction; Relative (related person); Research; Research Personnel; Resources; Role; Severities; Signal Transduction; Source; Stimulus; Structure of terminal stria nuclei of preoptic region; Uncertainty; United States National Institutes of Health; classical conditioning; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anxiety is complex set of reactions that include heightened arousal, muscular and autonomic responses, and shifts in attention, learning, and cognitive processing to cues indicating potential danger. Anxiety responses differ depending on the severity of the threat, its duration, and complexity. The aim of the study is to examine the neurobiology of anxiety induced by uncertainty in normal individuals without anxiety disorders and in patients with generalized anxiety disorder (GAD) using fMRI. Although fMRI studies have been conducted using classical conditioning paradigms, there is limited data on anxiety during tasks that involve uncertainty about the consequences for behavior. This pilot investigation will examine the effects of contingency uncertainty using behavioral performance measures, self-reported anxiety, and fMRI. In particular, uncertainty will be manipulated by altering both the probability of punishment relative to reinforcement, as well as the use of discriminative stimuli to signal changes in contingencies. Differences between anxious and non-anxious subjects as well as differences between conditions with low versus high uncertainty will be examined.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 焦虑是复杂的反应集，包括唤醒，肌肉和自主神经反应的增强，以及注意力，学习和认知处理的转变，向表明潜在危险的提示。焦虑反应因威胁的严重程度，其持续时间和复杂性而有所不同。该研究的目的是检查使用fMRI的普通焦虑症（GAD）患者的不确定性引起的焦虑症的神经生物学。 尽管已经使用经典调节范例进行了fMRI研究，但在任务过程中焦虑的数据有限，涉及对行为后果的不确定性。该试点调查将使用行为绩效指标，自我报告的焦虑和fMRI检查应急不确定性的影响。 特别是，通过改变相对于强化的惩罚概率以及使用判别性刺激来信号变化，可以通过改变惩罚的可能性来操纵不确定性。 焦虑和非焦虑受试者之间的差异以及低不确定性与高不确定性的条件之间的差异将被检查。