REGIONAL CEREBRAL BLOOD FLOW CHANGES DURING ANTICIPATORY ANXIETY

预期焦虑期间的区域脑血流变化

• 批准号: 6275516
• 负责人: Rudolf Franz Walter Hoehn-Saric
• 金额: $ 2.01万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275516
• 关键词: anxiety; blood flow measurement; clinical research; human subject; positron emission tomography

This study examined regional cerebral blood flow (RCBF) changes in subjects during worry. The study was conducted in the departments of Psychiatry and Radiology at The Johns Hopkins School of Medicine. It has been completed and was presented at the Society For Neuroscience annual meeting in New Orleans, October 25-30, 1997. An article is under preparation at this time. Following is a description of the methodology and preliminary analysis. Worrying occurs in normals under stress. It also constitutes an important ingredient of pathological anxiety where it occurs in absence of stressors. We examined the effect of worrying on RCBF in 6 right handed normal subjects, physically and mentally healthy and free of drugs (mean age 23 years, range 20-37, 4 female). They underwent 4 sequential PET scans (2 during neutral thoughts, 2 while worrying) using 015-H20 as tracer. Scans of neutral thoughts followed the listening to a 2-minute tape of flower arrangement, worries followed the listening to a 2 minute tape of self-recorded worries (ex. finance, illness in family, work). During scans, subjects continued to think about the topic previously heard on the tape until termination of the scan. RCBF during neutral thinking was compared with RCBF during worrying using MEDx and SPM96. Criteria for significance were: z-score > 3.11(p<.OOI)and at least 25 configuous 2x2x2mm voxels in the cluster. A relative increase in rCBF during worrying was found in the R caudate, R putamen, R inferior frontal gyrus, R inferior parietal lobule, R cerebellar vermis, L posterior cerebellar lobe and R pons. The results indicate right hemisphere and cerebellar activation while worrying. They are congruent with increased R hemisphere EEG activity in anxious individuals and increased RCBF seen in obsessive compulsive patients.

本研究检查了区域脑血流量（RCBF）的变化 忧虑期间的对象。 该研究是在以下部门进行的 约翰霍普金斯大学医学院的精神病学和放射学。 它 已完成并在神经科学学会上发表 年会于 1997 年 10 月 25 日至 30 日在新奥尔良举行。一篇文章如下 此时的准备工作。 以下是该方法的描述 并初步分析。 正常人在压力下会感到担忧。 它还构成了一个 缺席时发生的病理性焦虑的重要组成部分 的压力源。 我们检查了忧虑对 RCBF 的影响 6 右 交给正常受试者，身心健康且不受 毒品（平均年龄 23 岁，范围 20-37，4 名女性）。 他们经历了4 连续 PET 扫描（2 次在中性思维期间，2 次在忧虑期间） 015-H20 作为示踪剂。 聆听后扫描中立的想法 2分钟插花磁带，听着忧心忡忡 一段 2 分钟的录音带，记录了自己录制的忧虑（例如财务状况、生病的情况） 家庭、工作）。 在扫描过程中，受试者继续思考 之前在磁带上听到的主题，直到扫描结束。 RCBF 中立思维期间与忧虑期间 RCBF 进行比较 MEDx 和 SPM96。 显着性标准为：z 分数 > 3.11(p<.OOI)并且簇中至少有25个可配置的2x2x2mm体素。 在 R 尾状核中发现忧虑期间 rCBF 相对增加， R 壳核、R 额下回、R 顶下小叶、R 小脑蚓部、L 小脑后叶和 R 脑桥。 结果 表明忧虑时右半球和小脑的激活。 它们与焦虑时 R 半球脑电图活动增加一致。 个体和强迫症患者中观察到的 RCBF 增加。