REGIONAL CEREBRAL BLOOD FLOW CHANGES DURING ANTICIPATORY ANXIETY

预期焦虑期间的区域脑血流变化

• 批准号: 6275516
• 负责人: Rudolf Franz Walter Hoehn-Saric
• 金额: $ 2.01万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275516
• 关键词: anxiety; blood flow measurement; clinical research; human subject; positron emission tomography

This study examined regional cerebral blood flow (RCBF) changes in subjects during worry. The study was conducted in the departments of Psychiatry and Radiology at The Johns Hopkins School of Medicine. It has been completed and was presented at the Society For Neuroscience annual meeting in New Orleans, October 25-30, 1997. An article is under preparation at this time. Following is a description of the methodology and preliminary analysis. Worrying occurs in normals under stress. It also constitutes an important ingredient of pathological anxiety where it occurs in absence of stressors. We examined the effect of worrying on RCBF in 6 right handed normal subjects, physically and mentally healthy and free of drugs (mean age 23 years, range 20-37, 4 female). They underwent 4 sequential PET scans (2 during neutral thoughts, 2 while worrying) using 015-H20 as tracer. Scans of neutral thoughts followed the listening to a 2-minute tape of flower arrangement, worries followed the listening to a 2 minute tape of self-recorded worries (ex. finance, illness in family, work). During scans, subjects continued to think about the topic previously heard on the tape until termination of the scan. RCBF during neutral thinking was compared with RCBF during worrying using MEDx and SPM96. Criteria for significance were: z-score > 3.11(p<.OOI)and at least 25 configuous 2x2x2mm voxels in the cluster. A relative increase in rCBF during worrying was found in the R caudate, R putamen, R inferior frontal gyrus, R inferior parietal lobule, R cerebellar vermis, L posterior cerebellar lobe and R pons. The results indicate right hemisphere and cerebellar activation while worrying. They are congruent with increased R hemisphere EEG activity in anxious individuals and increased RCBF seen in obsessive compulsive patients.

这项研究检查了区域脑血流（RCBF）的变化 忧虑期间的受试者。 该研究是在 约翰·霍普金斯医学院的精神病学和放射学。 它 已经完成，并在神经科学协会中介绍 1997年10月25日至30日在新奥尔良举行的年度会议。 此时的准备。 以下是方法的描述 和初步分析。 担心在压力下的正常情况下发生。 它也构成 病理性焦虑的重要成分在不存在的情况下发生 压力源。 我们检查了6右6中担心RCBF的效果 在身体和精神上健康且不受欢迎的正常受试者 药物（平均年龄23岁，范围20-37，4女）。 他们接受了4 顺序的PET扫描（中性思想中有2个，在担心2） 015-H20作为示踪剂。 聆听后，中立思想的扫描 到2分钟的花胶带，聆听之后，担心 到2分钟的自我录制的烦恼（例如财务，生病） 家庭，工作）。 在扫描过程中，受试者继续考虑 主题以前在磁带上听到，直到扫描终止。 RCBF 在担心时，将中性思维与RCBF进行了比较 MEDX和SPM96。 显着性标准为：z得分> 3.11（p <.OI）和群集中至少25个配置2x2x2mm素。 在R Caudate中发现RCBF的相对增加， r putamen，r下额回，r下顶叶，r 小脑vermis，l后小脑叶和r pons。 结果 在担心的同时，指示右半球和小脑激活。 它们与焦虑中的r半球脑电图的增加相一致 在强迫症患者中，个人并增加了RCBF。