EFFECT OF CITALOPRAM ON WORRY-INDUCED RCBF CHANGES

西酞普兰对忧虑引起的 RBF 变化的影响

• 批准号: 7378898
• 负责人: Rudolf Franz Walter Hoehn-Saric
• 金额: $ 0.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378898
• 关键词: EFFECT; CITALOPRAM; WORRY; INDUCED; RCBF

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study added 4 patients with GAD to increase the sample and permit better statistical analysis of the data. Ten patients with GAD were scanned, using fMRI, before and after 7 weeks of treatment with citalopram. Imaging consisted in measuring BOLD responses while 1. inducing anxiety by hearing sentences that described a personal worry versus emotionally neutral sentences and 2.a decision making task, by measuring when a indistinctly drawn picture was recognized.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。该研究添加了 4 名 GAD 患者，以增加样本并更好地对数据进行统计分析。在西酞普兰治疗 7 周之前和之后，使用功能磁共振成像对 10 名广泛性焦虑症 (GAD) 患者进行了扫描。成像包括测量大胆的反应，同时 1. 通过听到描述个人担忧的句子与情绪中性的句子来诱发焦虑；2. 决策任务，通过测量何时识别出模糊绘制的图片。