CSHL 2020 Glia in Health and Disease Conference

CSHL 2020 胶质细胞健康与疾病会议

基本信息

批准号：
9899485
负责人：
DAVID J. STEWART
金额：
$ 1.5万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2021-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9899485
关键词：
Action Potentials Advanced Development Alzheimer&apos s Disease Amyotrophic Lateral Sclerosis Area Axon Behavior Biochemistry Biological Models Biology Brain Cell physiology Cells Central Nervous System Diseases Cicatrix Communities Data Development Disease Energy-Generating Resources Ensure Environment Event Exposure to Faculty Fostering Functional disorder Future Gene Mutation Genetic Goals Health Human Injury International Invertebrates Ions Laboratories Lead Length of Stay Link Metabolic Methodology Minority Molecular Molecular Biology Molecular Genetics Mutation Natural regeneration Nerve Regeneration Nervous System Physiology Nervous system structure Neurodegenerative Disorders Neuroglia Neurons Neurophysiology - biologic function Neurotransmitter Receptor Neurotransmitters Oral Organoids Participant Physiology Play Postdoctoral Fellow Research Research Institute Research Personnel Resource Development Role Schedule Scientist Series Signal Transduction Structure Synapses Synaptic plasticity Trauma Visualization Woman Work central nervous system injury cost extracellular genetic manipulation graduate student high resolution imaging human disease imaging approach in vivo imaging interest laboratory facility meetings member nervous system development nervous system disorder neural circuit new therapeutic target notch protein novel strategies novel therapeutic intervention novel therapeutics posters relating to nervous system repaired success symposium therapeutic target tool transmission process unpublished works

项目摘要

2020 Cold Spring Harbor Laboratory Conference GLIA IN HEALTH & DISEASE Abstract The proposed meeting on Glia in Health & Disease will be held at Cold Spring Harbor Laboratory from July 16 – 20, 2020. The goal of this conference is to provide an active forum for exchange of results in the rapidly advancing fields of glial biology and neuron-glia interactions. Glial cells comprise a diverse group of non-neuronal cells that are essential for nervous system development, circuit function, and neurological disease. These cells perform many important roles, such as controlling extracellular ion and neurotransmitter levels, providing neurons with energy sources, ensheathing axons to enable rapid transmission of action potentials with minimal metabolic cost, and phagocytosing debris. The development of advanced genetic tools is beginning to define the molecular events that establish and maintain these crucial interactions, providing new targets for therapeutic manipulation. In addition, recent studies demonstrate that glial cells play a much more active role in modulating the function of neural circuits; glial cells release signals that regulate neural firing, synaptic plasticity, and behavior, and express receptors for neurotransmitters. Glia also respond to CNS injury and disease by forming glial scars, engulfing dying neurons and synapses, and regenerating lost cells. However, these reactive changes can compromise the ability of glia to adequately support neurons, or in some cases promote further destruction. The mechanisms that control these changes and the consequences of their altered behavior in disease and injury are just beginning to be defined. It has become clear that many gene mutations linked to neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS), are also expressed in glia, and genetic manipulation studies are beginning to reveal how these mutations alter glial cell function and contribute to disease. This meeting will highlight the latest developments obtained through studies of invertebrate and vertebrate model systems, as well as human brain organoids, and provide exposure to technological advances in genetics, molecular biology, biochemistry, physiology, and high-resolution imaging. Using the goals and format of the seven prior extremely successful meetings as a guide, we plan to: 1) assemble an international meeting of scientists engaged in studies of glial biology and neuron-glia interactions; 2) discuss new and exciting developments in the field by selecting talks from openly submitted abstracts on the basis of scientific merit; 3) provide an opportunity for junior scientists of diverse backgrounds to present their data and engage in scientific discourse with more established investigators; and 4) promote collaborative interactions to accelerate the pace of discovery and identify novel approaches to treat diseases of the nervous system.

2020年冷泉港实验室会议胶质细胞在健康与疾病中的作用抽象的拟议的神经胶质细胞健康与疾病会议将在冷泉港举行实验室于 2020 年 7 月 16 日至 20 日举行。本次会议的目标是为交流快速发展的神经胶质生物学和神经元-神经胶质相互作用领域的成果。神经胶质细胞由一组不同的非神经元细胞组成，对神经系统至关重要这些细胞在发育、回路功能和神经疾病方面发挥着许多重要作用。作用，例如控制细胞外离子和神经递质水平，为神经元提供能量来源，包裹轴突以实现动作电位的快速传输最小的代谢成本和吞噬碎片先进遗传工具的开发。正在开始定义建立和维持这些关键的分子事件相互作用，为治疗操作提供了新的目标。证明神经胶质细胞在调节神经功能中发挥着更积极的作用神经胶质细胞释放调节神经放电、突触可塑性和行为的信号，神经胶质细胞还通过表达神经递质受体来对中枢神经系统损伤和疾病做出反应。形成神经胶质疤痕，吞噬垂死的神经元和突触，并再生丢失的细胞。然而，这些反应性变化可能会损害神经胶质细胞充分支持的能力神经元，或在某些情况下促进进一步破坏控制这些神经元的机制。他们的疾病和伤害行为的变化及其后果才刚刚开始很明显，许多基因突变与神经退行性疾病有关。阿尔茨海默病和肌萎缩侧索硬化症（ALS）等疾病也在神经胶质细胞中表达，基因操作研究开始揭示这些突变是如何发生的改变神经胶质细胞功能并导致疾病。本次会议将重点介绍最新的研究成果。通过对无脊椎动物和脊椎动物发育模型系统的研究获得作为人脑类器官，并提供遗传学技术进步的机会，分子生物学、生物化学、生理学和高分辨率成像。以之前七次极其成功的会议的形式为指导，我们计划：1）组建一个从事神经胶质生物学和神经胶质细胞研究的科学家国际会议 2）通过选择演讲来讨论该领域的新的和令人兴奋的发展；基于科学价值公开提交摘要；3）为初级学生提供机会不同背景的科学家展示他们的数据并与他们进行科学讨论更成熟的研究人员；4）促进协作互动以加快步伐发现并确定治疗神经系统疾病的新方法。