Pathology Core

病理学核心

• 批准号: 7729379
• 负责人: RUSSELL R BROADDUS
• 金额: $ 14.45万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-04 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7729379
• 关键词: Ascites; Benign; Biopsy Specimen; Blood; Cancer Center; Clinical; Collection; Cyst; Databases; Diagnostic; Doctor of Medicine; Formalin; Freezing; Future; Goals; Immunohistochemistry; In Situ Hybridization; Individual; Intranet; Liquid substance; Malignant neoplasm of ovary; Microdissection; Normal tissue morphology; Operative Surgical Procedures; Ovarian; Ovarian Diseases; Ovarian Tissue; Ovary; Paraffin Embedding; Paraffin Tissue; Pathologist; Pathology; Patients; Process; Prognostic Marker; Reproduction spores; Research Personnel; Research Project Grants; Resources; Sampling; Services; Slide; Source; Specimen; Staging; Testing; Tissue Microarray; Tissues; Tumor Bank; Universities; Urine; base; endometriosis; experience; prognostic; repository; research study; tumor; virtual

The individual research projects that make up this Ovarian Cancer SPORE application require the procurement, processing, and analysis of histopathological material from patients with ovarian cancer and benign ovarian diseases. The research projects have needs for frozen and formalin-fixed, paraffinembedded samples of tumor and normal tissue. The Pathology Core augments the already established M.D. Anderson Cancer Center Gynecological Tumor Bank and the P30-sponsored M.D. Anderson Cancer Center Centralized Tissue Repository with supporting database and intranet access. The Core provides tissue acquisition by experienced gynecological pathologists to assure high-quality tissues for the investigators participating in this SPORE as well as investigators of other SPOREs. The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, and histopathological expertise related to the specific needs for the research projects comprising this SPORE proposal. To achieve this goal, the Pathology Core has the following Specific Aims. Aim 1 is to maintain a frozen and paraffin-embedded tissue repository of ovarian cancer, benign ovarian processes, and normal ovary. The primary tissue source is operative and biopsy specimens submitted to the Department of Pathology at M.D. Anderson Cancer Center. In addition, a subcontract with Duke University provides additional ovarian tissues, particularly early stage ovarian cancers. Aim 2 is to provide pathological review for all clinical specimens utilized in the SPORE projects and to provide histopathological technical services as necessary. Such technical services include immunohistochemistry, in situ hybridization, creation of specific tissue microarray slides, and microdissection of tissue sections. Aim 3 is to establish a blood/urine/ascites fluid repository from patients undergoing surgery for ovarian cancer and benign ovarian processes. These fluids provide the resources for the systemic testing of putative prognostic and diagnostic markers derived from tissue-based expression array and CGH experiments. Aim 4 is to create and maintain a SPORE Database for all samples collected at both M.D. Anderson Cancer Center and Duke University. This SPORE Database is a virtual tissue repository that is electronically shared by all SPORE investigators.

构成此卵巢癌 SPORE 应用程序的各个研究项目需要 卵巢癌患者的组织病理学材料的采集、处理和分析 良性卵巢疾病。研究项目需要冷冻、福尔马林固定、石蜡包埋 肿瘤和正常组织样本。病理学核心增强了已经建立的 M.D. 安德森癌症中心妇科肿瘤库和 P30 赞助的 M.D. 安德森癌症 中心集中组织存储库，支持数据库和内联网访问。核心提供 由经验丰富的妇科病理学家采集组织，以确保为患者提供高质量的组织 参与该 SPORE 的调查员以及其他 SPORE 的调查员。 病理学核心的目标是提供冷冻组织、石蜡包埋组织和组织病理学 与构成本 SPORE 提案的研究项目的具体需求相关的专业知识。到 为了实现这一目标，病理学核心有以下具体目标。目标 1 是保持冻结和 卵巢癌、良性卵巢过程和正常卵巢的石蜡包埋组织库。这 主要组织来源是提交给医学博士病理学部的手术和活检标本。 安德森癌症中心。此外，与杜克大学的分包合同提供了额外的卵巢 组织，特别是早期卵巢癌。目标 2 是为所有临床提供病理学审查 SPORE 项目中使用的标本，并根据需要提供组织病理学技术服务。 此类技术服务包括免疫组织化学、原位杂交、特定组织的创建 微阵列载玻片和组织切片的显微切割。目标 3 是建立血液/尿液/腹水 来自接受卵巢癌和良性卵巢过程手术的患者的存储库。这些液体 为推定的预后和诊断标记物的系统测试提供资源 基于组织的表达阵列和 CGH 实验。目标 4 是创建和维护 SPORE 数据库 适用于在 M.D. 安德森癌症中心和杜克大学收集的所有样本。这个 SPORE 数据库 是一个虚拟组织存储库，由所有 SPORE 研究人员以电子方式共享。