Core 1: Pathology Core

核心 1：病理学核心

基本信息

批准号：
10005290
负责人：
JINSONG LIU
金额：
$ 21.97万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-22 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10005290
关键词：
Archives Ascites Award Back Basic Science Benign Biopsy Specimen Blood Blood specimen Cancer Center Charge Clinical Clinical Data Clinical Research Code Collection Confidentiality of Patient Information Consult Databases Development Diagnosis Disease Marker Doctor of Medicine Endometrium Evaluation Experimental Designs Feasibility Studies Female Genital Neoplasms Formalin Freezing Frozen Sections Funding Generations Genes Goals Human Immunohistochemistry In Situ Hybridization Individual Internet Intranet Laboratories Laboratory Research Link Liquid substance Malignant neoplasm of ovary Mammalian Oviducts Microdissection Microscopic Mucous Membrane Mus Normal tissue morphology Operative Surgical Procedures Ovarian Ovarian Diseases Ovary Paraffin Embedding Pathologic Pathologist Pathology Patients Pelvis Population Research Population Study Process Prognostic Marker Recurrence Research Research Personnel Research Project Grants Research Proposals Research Support Resources Risk Sampling Security Services Slide Solid Neoplasm Source Specimen Technology Testing Tissue Banks Tissue Embedding Tissue Microarray Tissue Sample Tissues Translational Research Tumor Bank Tumor Tissue Urine Xenograft procedure base career data access diagnostic biomarker early detection biomarkers experience experimental study novel quality assurance ranpirnase repository tumor virtual

项目摘要

Core 1: Pathology SUMMARY/ ABSTRACT The individual research projects comprising this Ovarian Cancer SPORE application require the procurement, processing, and analysis of histopathological material from patients with ovarian cancer and benign ovarian diseases. The research projects have needs for frozen and formalin-fixed, paraffin-embedded samples of tumor and normal tissue. The proposed Pathology Core augments the already established MD Anderson Cancer Center Gynecological Tumor Bank and the P30-sponsored MD Anderson Cancer Center Centralized Tissue Repository with supporting database and intranet access. The Core provides for tissue acquisition by experienced gynecological pathologists to assure high-quality tissues for the investigators participating in this SPORE as well as investigators of other SPOREs. The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, and histopathological expertise related to the specific needs of the research projects comprising this SPORE proposal. To achieve this goal, the Pathology Core proposes the following Specific Aims: Aim 1 is to maintain a frozen and paraffin-embedded tissue repository of ovarian cancer, benign ovarian processes, and normal ovary. The primary tissue source will be operative and biopsy specimens submitted to the Department of Pathology at MD Anderson Cancer Center. Aim 2 is to provide pathological review for all clinical specimens utilized in the SPORE projects and to provide histopathological technical services as necessary. Such technical services include immunohistochemistry, in situ hybridization, creation of specific tissue microarray slides, pathological evaluation of mouse tumors, and microdissection of tissue sections. Aim 3 is to establish a blood/urine/ascites fluid repository from patients undergoing surgery for ovarian cancer and benign ovarian processes. These fluids will provide the resources for the testing of putative prognostic and diagnostic markers derived from experiments in the SPORE projects. Aim 4 is to create and maintain a relational SPORE Database for all samples collected by the Pathology Core. This SPORE Database will provide for a virtual tissue repository that can be shared electronically with all SPORE investigators.

核心 1：病理学摘要/摘要构成卵巢癌 SPORE 应用程序的各个研究项目需要采购，卵巢癌和良性卵巢患者组织病理学材料的处理和分析疾病。该研究项目需要冷冻、福尔马林固定、石蜡包埋的样品肿瘤和正常组织。拟议的病理学核心增强了已经建立的 MD 安德森中心癌症中心妇科肿瘤库和 P30 赞助的 MD 安德森癌症中心集中支持数据库和内联网访问的组织存储库。核心提供组织采集经验丰富的妇科病理学家确保参与本次研究的研究人员获得高质量的组织 SPORE 以及其他 SPORE 的调查员。病理学核心的目标是提供冷冻组织、石蜡包埋组织和组织病理学与构成本 SPORE 提案的研究项目的具体需求相关的专业知识。达到为了实现这一目标，病理学核心提出了以下具体目标：目标 1 是维持冷冻和卵巢癌、良性卵巢过程和正常卵巢的石蜡包埋组织库。这主要组织来源将是提交给马里兰州病理学部的手术标本和活检标本安德森癌症中心。目标 2 是为试验中使用的所有临床标本提供病理学审查 SPORE 项目并根据需要提供组织病理学技术服务。此类技术服务包括免疫组织化学、原位杂交、特定组织微阵列载玻片的创建、病理学小鼠肿瘤的评估和组织切片的显微切割。目标 3 是建立血液/尿液/腹水来自接受卵巢癌和良性卵巢过程手术的患者的液体储存库。这些液体将为测试推定的预后和诊断标记物提供资源，这些标记物源自 SPORE 项目中的实验。目标 4 是为所有人创建和维护一个关系型 SPORE 数据库病理学核心收集的样本。该 SPORE 数据库将提供一个虚拟组织存储库可以通过电子方式与所有 SPORE 调查员共享。