Pathology Core

病理学核心

• 批准号: 10709234
• 负责人: JINSONG LIU
• 金额: $ 22.6万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709234
• 关键词: Archives; Ascites; Award; Benign; Biopsy Specimen; Cancer Center; Clinical; Clinical Data; Code; Colon; Confidentiality of Patient Information; Consult; Cyst; Databases; Development; Diagnosis; Drug resistance; Endometrium; Evaluation; Experimental Designs; Feasibility Studies; Female Genital Neoplasms; Formalin; Freezing; Frozen Sections; Funding; Generations; Goals; Gynecologic; Human; Immunohistochemistry; In Situ Hybridization; Individual; Institution; Internet; Intranet; Laboratories; Laboratory Research; Link; Malignant neoplasm of ovary; Mammalian Oviducts; Microscopic; Modeling; Mucous Membrane; Mus; Normal tissue morphology; Organoids; Ovarian; Ovarian Diseases; Ovary; Paraffin Embedding; Pathologic; Pathologist; Pathology; Patients; Population Research; Process; Research; Research Personnel; Research Project Grants; Research Proposals; Resources; Sampling; Security; Services; Slide; Solid Neoplasm; Source; Specimen; Technology; Testing; Tissue Banks; Tissue Embedding; Tissue Microarray; Tissues; Tumor Bank; Tumor Tissue; University of Texas M D Anderson Cancer Center; biomarker identification; career; data access; endometriosis; experience; experimental study; novel therapeutics; patient derived xenograft model; quality assurance; tumor; virtual

Core C: Pathology SUMMARY/ ABSTRACT The individual research projects comprising this Ovarian Cancer SPORE application require the procurement, processing, and analysis of histopathological material from patients with ovarian cancer and benign ovarian diseases. The research projects have needs for frozen and formalin-fixed, paraffin-embedded samples of tumor and normal tissue. The research projects also need patient-derived xenograft models and organoids to test the effects of novel drugs and define the mechanisms of drug resistance. The proposed Pathology Core augments the already established MD Anderson Cancer Center Gynecological Tumor Bank and the P30- sponsored MD Anderson Cancer Center Centralized Tissue Repository with supporting database and intranet access. The Core provides for tissue acquisition by experienced gynecological pathologists to assure high- quality tissues for the investigators participating in this SPORE as well as investigators of other SPOREs. The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, histopathological expertise, tissue arrays, patient-derived xenografts, and organoids related to the specific needs of the research projects comprising this SPORE proposal. To meet this goal, the following Specific Aims are proposed for this Core. Aim 1 is to maintain a frozen and paraffin-embedded tissue repository of ovarian cancers, normal ovaries, and benign ovarian processes (such as cysts and endometriosis). Aim 2 is to provide pathological review for all clinical specimens utilized in the SPORE projects and to provide histopathological and immunohistochemical technical services as necessary. Aim 3 is to create tissue microarrays, patient-derived xenografts (PDXs), and organoid models and maintain a relational SPORE Database. This SPORE Database will provide for a virtual tissue repository that can be shared electronically with all SPORE investigators.

核心 C：病理学总结/摘要 构成卵巢癌 SPORE 应用程序的各个研究项目需要采购， 卵巢癌和良性卵巢患者组织病理学材料的处理和分析 疾病。该研究项目需要冷冻、福尔马林固定、石蜡包埋的样品 肿瘤和正常组织。该研究项目还需要源自患者的异种移植模型和类器官 测试新药的效果并确定耐药机制。拟议的病理学核心 扩大了已经建立的 MD 安德森癌症中心妇科肿瘤库和 P30- 赞助 MD 安德森癌症中心集中组织存储库以及支持数据库和内联网 使用权。该核心由经验丰富的妇科病理学家提供组织采集，以确保高 为参与该 SPORE 的研究人员以及其他 SPORE 的研究人员提供优质组织。 病理学核心的目标是提供冷冻组织、石蜡包埋组织、组织病理学 与研究特定需求相关的专业知识、组织阵列、患者来源的异种移植物和类器官 包含此 SPORE 提案的项目。为实现这一目标，现提出以下具体目标 核。目标 1 是维持卵巢癌的冷冻石蜡包埋组织库，正常状态 卵巢和良性卵巢过程（如囊肿和子宫内膜异位症）。目标 2 是提供病理学 审查 SPORE 项目中使用的所有临床标本，并提供组织病理学和 必要时提供免疫组化技术服务。目标 3 是创建源自患者的组织微阵列 异种移植物 (PDX) 和类器官模型并维护关系 SPORE 数据库。这个 SPORE 数据库 将提供一个虚拟组织存储库，可以与所有 SPORE 研究人员以电子方式共享。