Pathology Core

病理学核心

• 批准号: 7961953
• 负责人: RUSSELL R BROADDUS
• 金额: $ 11.73万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7961953
• 关键词: Ascites; Benign; Biopsy Specimen; Blood; Blood specimen; Cancer Center; Cancer Center Support Grant; Cancer Research Project; Clinical; Clinical Data; Clinical Trials; Collaborations; Collection; Complement; Computerized Medical Record; Cyst; Databases; Diagnostic; Diagnostic Imaging; Electronics; Equipment; Evaluation; Examinations and Diagnoses; Faculty; Formalin; Freezing; Funding; Funding Agency; Future; Goals; Grant; Human Resources; Image; Immunohistochemistry; In Situ Hybridization; Individual; Institution; Instruction; Intranet; Laboratories; Laboratory Study; Liquid substance; Maintenance; Malignant neoplasm of ovary; Medical Records; Microdissection; Microscopic; Molecular; Mus; Normal tissue morphology; Operative Surgical Procedures; Ovarian; Ovarian Diseases; Ovary; Paraffin Embedding; Pathologist; Pathology; Pathology Report; Patients; Postdoctoral Fellow; Process; Prognostic Marker; Publications; Quality Control; Reproduction spores; Research; Research Personnel; Research Project Grants; Resources; Sampling; Services; Site; Slide; Source; Specimen; Specimen Handling; Staging; Structure; System; Technical Expertise; Techniques; Testing; Tissue Microarray; Tissues; Translational Research; Tumor Bank; University of Texas M D Anderson Cancer Center; Urine; Uterine Cancer; anticancer research; base; endometriosis; experience; meetings; oncology; operation; prognostic; programs; quality assurance; ranpirnase; repository; research study; tumor; virtual

PROJECT SUMMARY (See instructions): The individual research projects comprising this SPORE application require the procurement, processing, and analysis of histopathological material from patients with ovarian cancer and benign ovarian diseases. The research projects have needs for frozen and formalin-fixed, paraffin-embedded samples of tumor and normal tissue. The proposed Pathology Core augments the already established M. D. Anderson Cancer Center Gynecological Tumor Bank and the PSO sponsored M. D. Anderson Cancer Center Centralized Tissue Repository with supporting database and intranet access. The Core provides for tissue acquisition by experienced gynecological pathologists to assure high-quality tissues for the investigators participating in this SPORE as well as investigators of other SPOREs. The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, and histopathological expertise related to the specific needs of the research projects comprising this SPORE proposal. To achieve this goal, the Pathology Core proposes the following Specific Aims, which remain unchanged since the previous renewal. Aim 1 will maintain a frozen and paraffin-embedded tissue repository of ovarian cancer, benign ovarian processes, and normal ovary. The primary tissue source will be operative and biopsy specimens submitted to the Dept of Pathology at M. D. Anderson Cancer Center. Aim 2 will provide pathological review for all clinical specimens utilized in the SPORE projects and to provide histopathological technical services as necessary. Such technical services include immunohistochemistry, in situ hybridization, creation of specific tissue microarray slides, pathological evaluation of mouse tumors, and microdissection of tissue sections. Aim 3 will establish a blood/urine/ascites fluid repository from patients undergoing surgery for ovarian cancer and benign ovarian processes. These fluids will provide the resources for the systemic testing of putative prognostic and diagnostic markers derived from tissue-based expression array and CGH experiments. Aim 4 will create and maintain a relational SPORE Database for all samples collected by the Pathology Core. This SPORE Database will provide for a virtual tissue repository that can be electronically shared with all SPORE investigators.

项目摘要（参见说明）： 构成此 SPORE 应用程序的各个研究项目需要采购、加工、 卵巢癌和良性卵巢疾病患者的组织病理学材料的分析。 该研究项目需要冷冻、福尔马林固定、石蜡包埋的肿瘤样本和 正常组织。拟议的病理学核心增强了已经建立的 M. D. Anderson 癌症 中心妇科肿瘤库和 PSO 赞助的 M.D. 安德森癌症中心集中化 支持数据库和内联网访问的组织存储库。核心提供组织采集 经验丰富的妇科病理学家确保参与本次研究的研究人员获得高质量的组织 SPORE 以及其他 SPORE 的调查员。病理学核心的目标是提供冷冻 组织、石蜡包埋组织和与特定需求相关的组织病理学专业知识 包含此 SPORE 提案的研究项目。为了实现这一目标，病理学核心提出 遵循自上次更新以来保持不变的具体目标。目标1将保持冻结状态 以及卵巢癌、良性卵巢过程和正常卵巢的石蜡包埋组织库。 主要组织来源将是提交给 M. 病理学部的手术标本和活检标本。 D.安德森癌症中心。目标 2 将为试验中使用的所有临床标本提供病理学审查 SPORE 项目并根据需要提供组织病理学技术服务。此类技术服务 包括免疫组织化学、原位杂交、特定组织微阵列载玻片的创建、病理学 小鼠肿瘤的评估和组织切片的显微切割。目标 3 将建立血液/尿液/腹水 来自接受卵巢癌和良性卵巢过程手术的患者的液体储存库。这些 液体将为假定的预后和诊断标记物的系统测试提供资源 源自基于组织的表达阵列和 CGH 实验。目标 4 将创建并维护 关系型 SPORE 数据库，包含病理学核心收集的所有样本。该 SPORE 数据库将 提供一个虚拟组织存储库，可以与所有 SPORE 研究人员以电子方式共享。