Developmental Research Program

发展研究计划

基本信息

批准号：
10006201
负责人：
RUSSELL R BROADDUS
金额：
$ 15.53万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10006201
关键词：
Address Award Basic Science Budgets Cancer Biology Cancer Patient Clinical Clinical Investigator Clinical Research Collaborations Communities Community Developments Development Discipline Doctor of Medicine Doctor of Philosophy Early Diagnosis Educational Activities Endometrial Endometrial Carcinoma Financial Support Fostering Funding Future Genomics Goals Gynecologic Human Incidence Intervention Laboratories Lead Letters Malignant Neoplasms Methodology MicroRNAs Nature Outcome Pathology Pilot Projects Plant Roots Prevention Prevention strategy Process Program Research Project Grants Quality of life Research Research Personnel Research Project Grants Resources Rest Scientist Signal Transduction Translational Research Uterine Cancer Work anticancer research base effective therapy flexibility high risk improved improved outcome innovation instrumentation mortality novel professor programs recruit sound success translational scientist translational study

项目摘要

Developmental Research Program SUMMARY/ ABSTRACT The purpose of the Developmental Research Program (DRP) is to fund promising projects by investigators whose current work may not focus exclusively on endometrial cancer, but who propose highly innovative translational studies of endometrial cancer that could become full SPORE projects or compete successfully for funding outside of the SPORE mechanism. The DRP provides a unique venue for making available significant financial support, and for demonstrating active institutional support, through a program that is rapidly responsive to new ideas or initiatives. Moreover, this program is rooted in a spirit of collaboration espoused by the SPORE investigators, who have an extensive track-record of bringing investigators from other disciplines into the field of endometrial cancer research. The strength of the Developmental Research Program rests in its ability to make available financial support and access all the critical expertise and resources within the entire SPORE, including SPORE Cores. This will allow us to develop important collaborative, multi-investigator, multi- institutional research projects with the support of innovative, investigator-initiated projects that have the potential to flourish into reliable and productive translational research projects for the SPORE. Pre-proposals in the form of 1 page letters of intent will be solicited by the Program, and applicants with pre-proposals that are highly competitive for the goals of this program will be invited to submit a full proposal for review. The DRP Directors will help investigators submitting proposals to formulate relevant translational research aims and plans, as many applicants may not have prior expertise in this type of research. This process will therefore be a major educational activity that is further anticipated to stimulate translational research in endometrial cancer and encourage the participation of both basic science researchers and clinical investigators in translational research. The DRP will be led by Thomas Burke, M.D., the founding Endometrial Cancer SPORE PI and current Vice President of the MD Anderson Cancer Network, and Wei Zhang, Ph.D., a Professor in the Department of Pathology with specific expertise in cancer biology, genomics, and construction of miRNA signaling networks. Russell Broaddus, M.D., Ph.D., SPORE Co-PI, will provide oversight to the DRP. The DRP is critical to the continued success of the SPORE, as shown by four former DRP awardees now involved as research project Co-PIs in this application, and a fifth is an important co-investigator on a SPORE project. Two other former DRP awardees will provide their scientific expertise by serving on the External Advisory Board.

发展研究计划摘要/摘要发展研究计划 (DRP) 的目的是资助研究人员有前途的项目他们目前的工作可能不仅仅专注于子宫内膜癌，但他们提出了高度创新的建议子宫内膜癌的转化研究可能成为完整的 SPORE 项目或成功竞争 SPORE 机制之外的资金。 DRP 提供了一个独特的场所来提供重要的信息财政支持，并通过一项迅速实施的计划展示积极的机构支持对新想法或倡议做出反应。此外，该计划植根于以下组织所倡导的合作精神： SPORE 调查员，他们在引进其他学科的调查员方面有着丰富的记录进入子宫内膜癌研究领域。发展研究计划的优势在于其有能力提供财务支持并获得整个组织内的所有关键专业知识和资源 SPORE，包括 SPORE 核心。这将使我们能够开展重要的协作、多研究者、多研究在创新的、研究者发起的项目的支持下开展的机构研究项目潜力为 SPORE 发展成为可靠且富有成效的转化研究项目。预提案该计划将征集一页意向书的形式，并提出预提案的申请人对于该计划的目标具有高度竞争力的人将被邀请提交完整的提案以供审查。发展计划主任将帮助研究者提交提案，制定相关的转化研究目标和计划，因为许多申请人可能没有此类研究的先前专业知识。因此，这个过程将是一项主要的教育活动，预计将进一步促进子宫内膜癌的转化研究并鼓励基础科学研究人员和临床研究人员参与转化研究。 DRP 将由子宫内膜癌 SPORE PI 创始人 Thomas Burke 医学博士领导 MD 安德森癌症网络现任副总裁，张伟博士，该中心教授病理学系在癌症生物学、基因组学和 miRNA 构建方面拥有专业知识信号网络。 Russell Broaddus，医学博士、哲学博士、SPORE 联合首席研究员，将对 DRP 进行监督。这 DRP 对于 SPORE 的持续成功至关重要，四位前 DRP 获奖者现在参与其中表明了这一点作为该应用程序中的研究项目联合负责人，第五位是 SPORE 项目的重要联合研究员。另外两名前 DRP 获奖者将通过担任外部顾问来提供他们的科学专业知识木板。