Pathology Core

病理学核心

基本信息

批准号：
7962038
负责人：
RUSSELL R BROADDUS
金额：
$ 9.42万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7962038
关键词：
Animal Model Archives Ascites Back Biopsy Biopsy Specimen Blood Cancer Center Cancer Patient Cervical dysplasia Charge Clinical Clinical Data Clinical Laboratory Information Systems Clinical Trials Code Collaborations Collection Complex Confidentiality of Patient Information Consult Consultations Data Databases Development Diagnosis Diagnostic Disease Marker Doctor of Medicine Early Diagnosis Endometrial Endometrial Carcinoma Endometrial Hyperplasia Evaluation Feasibility Studies Formalin Freezing Frozen Sections Funding Future Genes Grant Hyperplasia Hysterectomy Image Immunohistochemistry In Situ Hybridization Individual Instruction Internet K-Series Research Career Programs Laboratories Laboratory Research Learning Liquid substance Medical Records Mentors Microscopic Mus Normal tissue morphology Operative Surgical Procedures Paraffin Paraffin Embedding Pathologic Pathology Patients Primary Neoplasm Procedures Process Prognostic Marker Publications Rattus Recurrence Reproduction spores Research Research Personnel Research Project Grants Research Proposals Resources Risk Sampling Security Services Site Slide Source Specimen System Technical Expertise Technology Testing Tissue Banks Tissues Translational Research Treatment Protocols Tumor Bank University of Texas M D Anderson Cancer Center Urine Uterine Cancer Uterine Fibroids base computerized endometriosis meetings novel population based quality assurance repository research study standard care tumor virtual

项目摘要

PROJECT SUMMARY (See instructions): The individual researcin projects comprising this Endometrial Cancer SPORE require the procurement, processing, and microscopic analysis of normal endometrial tissues and endometrial cancers from surgical hysterectomy specimens. In addition, several of the SPORE projects propose animal model studies that will require histological processing and careful pathological assessment of rat and mouse uterine tissues. In this proposal, the Core will continue its active commitment to high-quality translational research in endometrial cancer that began with initial SPORE funding in 2003. Since 2003, the Gore has provided endometrial tissues and pathological expertise to 20 different investigators, 9 of which were outside of MDACC. These collaborations beginning in 2003 have resulted in 57 publications and 2 NIH/NCI R01 grants in which Core materials from endometrial cancer patients were used. Importantly, the Core enthusiastically supports trainees in learning translational research; 23 different trainees (9 different trainee mentors) have been provided with Core resources and expertise since 2003. The following Specific Aims are proposed for this Core. Aim 1 is to maintain a frozen and paraffinembedded tissue repository of endometrial cancers, hyperplasias, and normal endometrial samples. Aim 2 is to provide pathological review for all clinical specimens utilized in the SPORE projects and for related clinical trials and to provide histopathological technical services as necessary. This includes histological processing and microscopic evaluation of uterine tissues derived from the proposed mouse and rat experiments in several projects. Aim 3 is to establish a blood/urine/ascites fluid collection from patients undergoing hysterectomy for endometrial cancer and endometrial hyperplasia and from patients undergoing hysterectomy for non-endometrial pathology (uterine leiomyomas, cervix dysplasia, endometriosis). Such fluids will provide resources for the future testing of putative diagnostic/prognostic markers for endometrial cancer. Aim 4 is to create and maintain a database for all frozen and paraffin-embedded endometrial tissues and fluids collected by the Core.

项目摘要（参见说明）：构成子宫内膜癌孢子的各个研究项目需要采购，对手术中正常子宫内膜组织和子宫内膜癌的处理和显微分析子宫切除标本。此外，一些 SPORE 项目提出了动物模型研究，这些研究将需要对大鼠和小鼠子宫组织进行组织学处理和仔细的病理评估。在这个根据提案，核心将继续积极致力于子宫内膜的高质量转化研究癌症始于 2003 年最初的 SPORE 资助。自 2003 年以来，戈尔提供了子宫内膜向 20 名不同的研究人员提供组织和病理学专业知识，其中 9 名来自 MDACC 之外。这些自 2003 年开始的合作已产生 57 篇出版物和 2 项 NIH/NCI R01 资助，其中核心使用来自子宫内膜癌患者的材料。重要的是，核心热心支持学习转化研究的学员； 23名不同的实习生（9名不同的实习生导师）自 2003 年起提供核心资源和专业知识。为此核心提出以下具体目标。目标 1 是保持冷冻和石蜡包埋子宫内膜癌、增生和正常子宫内膜样本的组织库。目标2 是为 SPORE 项目中使用的所有临床标本以及相关的标本提供病理学审查临床试验并根据需要提供组织病理学技术服务。这包括组织学对来自所提议的小鼠和大鼠的子宫组织进行处理和显微镜评估在多个项目中进行实验。目标 3 是收集患者的血液/尿液/腹水因子宫内膜癌和子宫内膜增生而接受子宫切除术的患者针对非子宫内膜病变（子宫肌瘤、宫颈发育不良、子宫内膜异位症）的子宫切除术。这样的液体将为子宫内膜假定的诊断/预后标志物的未来测试提供资源癌症。目标 4 是创建和维护所有冷冻和石蜡包埋子宫内膜组织的数据库以及核心收集的液体。