HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes

HEALing LB3P：分析生物力学、生物和行为表型

基本信息

批准号：
9897962
负责人：
Gwendolyn A Sowa
金额：
$ 1675.62万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-26 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9897962
关键词：
Academic Medical Centers Address Affect Behavioral Biological Biomechanics Characteristics Chronic Care Chronic low back pain Client satisfaction Clinical Clinical Informatics Collaborations Collection Communities Complex Coupled Data Data Analyses Data Analytics Data Collection Data Set Development Ensure Environment Future Individual Informatics Institution Laboratories Lead Low Back Pain Mission Outcome Pathway interactions Patient Care Patient Outcomes Assessments Patient Rights Patient-Focused Outcomes Patients Phenotype Protocols documentation Quality of life Research Research Personnel Research Project Grants Resources Services Standardization Syndrome System Testing Time Translating Translations Treatment outcome Universities Work biopsychosocial care costs care delivery chronic care model clinical care collaborative approach computerized data processing cost data sharing experience healing improved improved outcome insight member multimodality novel opioid use pain patient personalized approach predictive tools prospective test response success therapy design treatment response

项目摘要

ABSTRACT The purpose of the University of Pittsburgh Low Back Pain: Biological, Biomechanical, Behavioral Phenotypes (LB3P) Mechanistic Research Center is to perform in-depth phenotyping of patients with chronic low back pain (CLBP), using a multi-modal approach, to characterize patients and provide insight into the phenotypes associated with experience of CLBP to direct targeted and improved treatments. This new center will uniquely address the critical challenge facing care for patients with CLBP, which is the rising costs of care related to failed treatments, and resultant loss of quality of life and function with increasing reliance on opioid use resulting from our inability to properly select patients for properly targeted treatments with a high likelihood of success. The LB3P MRC will be formed of three Research Cores, which will be primarily responsible for data collection and analysis of the three key contributors to CLBP (Biological, Biomechanical, and Behavioral); three support cores primarily responsible for data organization, processing, storage and dissemination, including interactions with the BACPAC (Administrative, Clinical, and Informatics); and one Research Project (deep phenotyping of CLBP patient characteristics and response to treatments), serving to leverage all of the services and products of the individual cores into the development of a unique clinical set of phenotypes associated with response to treatment to guide properly targeted, individualized future care models for CLBP. This approach will leverage and integrate distinctive resources at the University of Pittsburgh laboratories to deliver quantified biomechanical, biological, and behavioral characteristics, functional assessments and patient-reported outcomes, coupled with advanced data analytics using a novel Network Phenotyping Strategy (NPS). A comprehensive and integrated biopsychosocial approach will be employed, which is necessary to improve treatment for this complex and multi-dimensional condition. It is critical that the interaction of individual variables is maintained in any phenotyping strategy, since in the syndrome of CLBP there is significant interaction of each contributor, and this is an important strength of the proposed approach. The formation of this center will build upon existing strengths within the University of Pittsburgh research community and focus efforts around the critical challenge of CLBP, and the collaborative approach will serve as an important resource for the BACPAC community. The LB3P MRC will coordinate the interdisciplinary expertise of clinicians and researchers to study the contributors and predictors of CLBP, and to propose a culminating research project that promises to translate the findings to clinical utilization and change the paradigm of care for CLBP. The proposed approach, by eliminating isolated and disconnected approaches to treatment, and instead focusing on personalized patient- centric approaches, will yield improved outcomes and patient satisfaction. In addition, the robust environment, including an academic medical center with an integrated care delivery and finance system, will ensure rapid and efficient translation of the results into novel care models for CLBP patients.

抽象的匹兹堡大学腰痛研究的目的：生物、生物力学、行为表型 (LB3P) 机制研究中心将对慢性腰痛患者进行深入的表型分析 (CLBP)，使用多模式方法来描述患者特征并深入了解表型与 CLBP 的经验相关，以指导有针对性和改进的治疗。这个新中心将以独特的方式解决 CLBP 患者护理面临的关键挑战，即与以下相关的护理成本不断上升治疗失败，并随着对阿片类药物使用的日益依赖而导致生活质量和功能下降由于我们无法正确选择患者进行适当的针对性治疗，很可能成功。 LB3P MRC将由三个研究核心组成，主要负责数据 CLBP 的三个关键贡献者（生物、生物力学和行为）的收集和分析；三个支撑核心，主要负责数据组织、处理、存储和传播，包括与 BACPAC（行政、临床和信息学）的互动；和一项研究项目（深 CLBP 患者特征和治疗反应的表型分析），用于利用所有服务和各个核心的产品开发出与相关的一组独特的临床表型对治疗的反应，以指导 CLBP 未来有针对性、个性化的护理模式。这种做法将利用和整合匹兹堡大学实验室的独特资源来提供量化的生物力学、生物学和行为特征、功能评估和患者报告结果，加上使用新颖的网络表型策略 (NPS) 的高级数据分析。一个将采用全面综合的生物心理社会方法，这对于改善针对这种复杂且多维的情况进行治疗。个体之间的互动至关重要在任何表型分析策略中都会保留变量，因为在 CLBP 综合征中，存在显着的每个贡献者之间的互动，这是所提出方法的一个重要优势。这个的形成该中心将利用匹兹堡大学研究界的现有优势并集中精力围绕 CLBP 的关键挑战，协作方法将成为 BACPAC 社区。 LB3P MRC 将协调临床医生和研究人员的跨学科专业知识研究 CLBP 的贡献者和预测因素，并提出一个最终的研究项目，该项目有望将研究结果转化为临床应用并改变 CLBP 的护理模式。所提出的方法，通过消除孤立和脱节的治疗方法，转而关注个性化的患者以中心为中心的方法将产生更好的结果和患者满意度。此外，强大的环境，包括一个具有综合护理服务和财务系统的学术医疗中心，将确保快速和将结果有效转化为 CLBP 患者的新型护理模式。