Attentional Mechanisms of Cognitive Compensation in Subjective Cognitive Decline and AD Risk

主观认知下降和 AD 风险中认知补偿的注意机制

• 批准号: 10738600
• 负责人: Kimberly Albert
• 金额: $ 11.16万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10738600
• 关键词: Academic Medical Centers; Address; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease pathology; Alzheimer' s disease risk; Amyloid beta-42; Amyloidosis; Anti-Cholinergics; Area; Attention; Behavioral Sciences; Brain; Clinical; Clinical Research; Clinical Trials; Cognition; Cognition Disorders; Cognitive; Cognitive aging; Collaborations; Compensation; Complement; Deterioration; Development; Disease Progression; Doctor of Philosophy; Elderly; Electroencephalography; Environment; Experimental Models; Failure; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Human; Impaired cognition; Impairment; Individual; Intervention; Intervention Studies; K-Series Research Career Programs; Leadership; Maintenance; Measures; Medial; Medicine; Memory; Mentors; Neurobiology; Neurosciences; Neurotransmitters; Pathologic; Pathology; Performance; Pharmaceutical Preparations; Pharmacologic Substance; Placebos; Process; Psyche structure; Psychiatry; Research; Research Personnel; Research Project Grants; Research Proposals; Resources; Role; Severities; System; Temporal Lobe; Testing; Therapeutic; Training; Translating; Work; aging brain; basal forebrain; career; career development; cholinergic; clinical diagnosis; cognitive change; cognitive enhancement; cognitive function; cognitive neuroscience; cognitive performance; cognitive process; cognitive testing; experience; functional magnetic resonance imaging/electroencephalography; improved; neurobiological mechanism; neuroimaging; neuropathology; pre-clinical; preservation; professor; research study; tau Proteins; temporal measurement

Attentional Mechanisms of Cognitive Compensation in Subjective Cognitive Decline and AD Risk Candidate: Dr. Kimberly Albert, PhD is an assistant professor in the Department of Psychiatry and Behavioral Sciences at the Vanderbilt University Medical Center with a strong background in cognitive and systems neuroscience. Her long-term career goals include gaining the necessary training to become an independent investigator with research focused on identifying brain mechanisms that maintain cognitive function in the early stages of pathological brain aging and may underlie subjective cognitive decline (SCD). Career Development: Dr. Albert seeks to translate her mechanistic work to clinical research that mitigates the cognitive effects of early AD pathology. Dr. Albert requires advanced training in 1) clinical trials development, implementation, and management.; 2) the clinical presentation, course, and assessment of SCD and Alzheimer’s Disease; 3) neuroimaging using EEG/ERP to provide the temporal resolution to assess brain activity related to component cognitive processes. This training will build on Dr. Albert’s prior experience in human cognitive neuroscience using functional neuroimaging to examine the neurobiology of cognitive aging. Research Project: These career goals will be facilitated through a research study focused on the role of cholinergic support of attention as a cognitive compensatory mechanism in SCD. As early AD-related neuropathology affects medial temporal areas important for memory, there may be a compensatory enhancement of attention network activity via increased cholinergic function. Although memory performance is maintained through this compensatory process, subtle cognitive changes may be obscured. Additionally, the individual may experience this change as increased required effort or occasional memory failures which result in subjective cognitive decline despite normal cognitive testing. Cholinergic activity may be an integral component of maintaining memory function in early AD, through enhanced attention. The proposed study focuses on attention as a compensatory cognitive process and the relationships between AD-related pathology and cholinergic neurotransmitter mechanisms that may underlie this compensation in SCD. The ultimate aim of the study is to identify the role of attention network changes in supporting cognitive performance in SCD using EEG and fMRI as complimentary neuroimaging approaches. Anticholinergic challenge will be employed to model AD progression and examine the relationships between cognitive concerns, attention, and AD pathology. The results of this study will improve our understanding of brain changes that maintain cognitive performance in the early stages of AD pathology and may underlie SCD. Environment: Mentoring, collaborations, and resources available through the Department of Psychiatry and Behavioral Sciences, the Center for Cognitive Medicine, and the Vanderbilt Alzheimer’s Disease Research Center provide an ideal environment to support Dr. Albert’s transition to independent funding and leadership in the field of attentional changes in cognitive aging.

主观认知下降和 AD 风险中认知补偿的注意机制 候选人：Kimberly Albert 博士，精神病学和行为学系助理教授 范德比尔特大学医学中心的科学领域拥有强大的认知和系统背景 她的长期职业目标包括获得必要的培训以成为独立的人。 研究人员的研究重点是确定早期维持认知功能的大脑机制 大脑病理性老化的各个阶段，可能是主观认知能力下降（SCD）的基础。 职业发展：阿尔伯特博士寻求将她的机械工作转化为临床研究，以减轻 Albert 博士需要在 1) 临床试验开发方面进行高级培训， 实施和管理。；2) SCD 和阿尔茨海默病的临床表现、病程和评估 疾病；3) 使用 EEG/ERP 提供时间分辨率来评估与疾病相关的大脑活动 该培训将以阿尔伯特博士先前在人类认知方面的经验为基础。 神经科学利用功能性神经影像来检查认知衰老的神经生物学。 研究项目：这些职业目标将通过一项专注于以下角色的研究来促进 胆碱能支持注意力作为 SCD 的认知补偿机制，与早期 AD 相关。 神经病理学影响对记忆很重要的内侧颞区，可能存在代偿性 通过增加胆碱能功能来增强注意力网络活动，尽管记忆性能受到影响。 通过这种补偿过程，微妙的认知变化可能会被掩盖。 个人可能会经历这种变化，因为所需的努力增加或偶尔的记忆障碍导致 尽管认知测试正常，但主观认知能力下降可能是一个不可或缺的因素。 通过增强注意力来维持 AD 早期记忆功能的组成部分。 拟议的研究重点关注作为补偿性认知过程的注意力以及两者之间的关系 AD 相关的病理学和胆碱能神经递质机制可能是 SCD 补偿的基础。 该研究的最终目的是确定注意力网络变化在支持认知方面的作用 使用脑电图和功能磁共振成像作为补充神经影像学方法在 SCD 中的表现。 挑战将用于模拟 AD 进展并检查认知问题之间的关系， 这项研究的结果将提高我们对大脑变化的理解。 在 AD 病理学的早期阶段维持认知表现，并可能是 SCD 的基础。 环境：通过精神病学系提供的指导、合作和资源 行为科学、认知医学中心和范德比尔特阿尔茨海默病研究 中心提供了一个理想的环境来支持阿尔伯特博士过渡到独立资助和领导地位 认知衰老中的注意力变化领域。