16/24 Healthy Brain and Child Development National Consortium DIVERSITY SUPPLEMENT

16/24 健康大脑和儿童发展国家联盟多样性补充

• 批准号: 10765565
• 负责人: Nathan A Fox
• 金额: $ 5.88万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10765565
• 关键词: 10 year old; Acceleration; Adolescence; Adolescent; Anxiety; Behavioral; Biological; Brain; Caregivers; Child; Child Development; Childhood; Cognitive; Data; Data Collection; Development; Emotional; Environment; Faculty; Genetic; Individual; Mental Health; Outcome; Pregnant Women; Public Health; Research; Research Personnel; Risk Factors; Stress; Structure; Teenagers; Thick; Training; Variant; Work; adverse outcome; behavioral health; behavioral outcome; brain volume; career; depressive symptoms; fetal drug exposure; fetal substance exposure; graduate school; graduate student; infancy; interest; offspring; parent grant; parent project; postnatal; prenatal; prospective; resilience; social; sociodemographic factors; substance use; training project

Abstract Substance use among pregnant women is a substantial public health concern that can result in adverse outcomes in offspring. The aims of the Healthy Brain and Child Development (HBCD) parent grant are to: 1) examine behavioral, cognitive, biological, social, and emotional aspects of child development from prenatal to 10 years old and 2) examine the impacts of sociodemographic factors, stress and mental health, genetics, and prenatal substance exposure on child development. However, the parent project is focused on data collection and on the developmental periods of infancy and childhood. The proposed work will use existing data from the F.U.T.U.R.E.S. study (“Following Urban Teens: Unique and Resilient at Every Step, DA021059 ), which examined the impact of prenatal substance exposure on behavioral and brain development in adolescence. In Aim 1 of this proposed supplement, the Candidate will examine interactions between PDE and caregiver mental health on behavioral outcomes in adolescence. We hypothesize that the combination of PDE and poor caregiver mental health (characterized by symptoms of depression, anxiety, and/or stress) will produce the worst child outcomes. Exploratory analyses will probe whether effects vary as a function of type of substance or duration of use. In Aim 2, the Candidate will examine interactions between PDE and caregiver mental health on adolescent brain structure and function. We hypothesize that the combination of PDE and poor caregiver mental health will be associated with variations in brain volume and cortical thickness compared to individuals with either one risk-factor alone or no risk factors. This work will provide a better understanding of maternal mental health and caregiver environment that influence many aspects of child development. As a full-time faculty researcher, the Candidate does not have the opportunity to explore research interests outside of the parent project and pursue training that would make her a competitive prospective graduate student. Ultimately, this training project will help accelerate the Candidate’s transition to graduate school and her research career trajectory.

抽象的 孕妇中的药物使用是一个实质性的公共卫生问题，可能导致 后代的不利结果。健康的大脑和儿童发育的目的（HBCD） 父母赠款是：1） 检查行为，认知，生物学，社会和情感方面 从产前到10的儿童发展 年龄和2）检查 社会人口统计学因素，压力和心理健康，遗传学和 产前物质暴露 关于儿童发展。但是，父项目的重点是数据收集和 婴儿期的发展期 童年。拟议的工作将使用现有数据 F.U.T.U.R.E.S.研究（“遵循城市青少年：独特而有弹性的步骤， DA021059 ），研究了产前物质暴露对行为和行为的影响 青少年的大脑发育。在本提议的补充的目标1中，候选人将 检查PDE与护理人员心理健康之间有关行为结果的互动 青少年。我们假设PDE和不良护理人员心理健康的结合 （以 抑郁症，动画和/或压力的症状将产生最糟糕的孩子 结果。探索性分析将探测效果是否随着类型的函数而变化 实质或使用时间。在AIM 2中，候选人将检查PDE之间的相互作用 和照顾者心理健康对青少年大脑 结构和功能。我们假设 PDE和护理人员心理健康的结合将与大脑的变化有关 与单独使用一个风险因素或无风险的个体相比，体积和皮质厚度 因素。这项工作将 更好地了解孕产妇的心理健康和护理人员 影响儿童发展许多方面的环境。作为一名专职教师研究员 候选人没有机会 探索父母之外的研究兴趣 项目和追求将使她的培训 有竞争力的潜在研究生。 最终， 该培训项目将有助于加速候选人向研究生院的过渡 以及她的研究职业轨迹。