Gene-Environment Interplay and Alcohol Use among Racially-Ethnically Diverse Youth: A Developmentally and Culturally Informed Approach

种族-民族多元化青年中的基因-环境相互作用和酒精使用：一种发展和文化知情的方法

• 批准号: 10779197
• 负责人: Jinni Su
• 金额: $ 33.33万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10779197
• 关键词: 10 year old; Acceleration; Adolescence; Adolescent; Adult; African American; Age; Alcohol abuse; Alcohol consumption; Alcohols; American; Behavior; Behavioral Genetics; Black race; Brain; Buffers; Cause of Death; Child; Child Health; Child Rearing; Childhood; Complex; Data; Development; Disease; Environment; Environmental Risk Factor; Equation; Etiology; European; European ancestry; Genes; Genetic; Genetic Risk; Health Disparities Research; Hispanic; Human; Impulsivity; Individual; Intervention; Latinx; Link; Mediating; Mission; Modeling; Outcome; Pathway interactions; Polygenic Traits; Population; Population Heterogeneity; Prevention; Prevention program; Process; Public Health; Research; Risk; Risk Factors; Role; Sampling; Science; Sex Differences; Shapes; Stressful Event; Survival Analysis; Symptoms; Temperament; Testing; Twin Multiple Birth; United States; United States National Institutes of Health; Youth; alcohol risk; alcohol use disorder; alcohol use initiation; cognitive development; contextual factors; cultural values; deter alcohol use; early alcohol use; ethnic diversity; ethnic minority population; gene environment interaction; genome-wide; genomic data; health disparity; high risk; insight; intervention program; peer; perceived discrimination; person centered; phenotypic data; prospective; protective factors; racial discrimination; racial diversity; racial minority population; societal costs; substance use; trait; underage drinking

PROJECT SUMMARY/ABSTRACT Alcohol is the most widely used substance and the third-leading preventable cause of death in the United States. Initiation of alcohol use typically occurs in adolescence, and early onset alcohol use (< age 15) has been associated with prolonged negative outcomes such as increased risk for AUD. The development of alcohol use and AUD is influenced by genetic and environmental factors, and the complex interactions among them (i.e., gene-environment interaction or GE). Yet, the majority of genetic and GE research has been 1) conducted with populations of European ancestry, and 2) focused on alcohol outcomes among individuals who have already initiated alcohol use or developed AUD. Thus, there is limited understanding of GE processes in racially-ethnically diverse populations, and how genetic risk manifests earlier in development in order to inform early prevention and intervention efforts. Furthermore, despite culture being an important context that shapes human behavior, cultural risk and protective factors have been largely overlooked in GE research. We seek to advance the understanding of etiology of alcohol use and AUD among racially-ethnically diverse populations by taking a developmentally and culturally informed approach to study GE processes. This project draws data from the ongoing Adolescent Brain and Cognitive Development (ABCD) Study, which includes rich genomic and phenotypic data from a longitudinal sample (N = 11,875; 52.1% White, 15.0% Black, and 20.3% Hispanic/Latinx) of racially-ethnically diverse children from late childhood (9-10 years old) through adolescence. The project examines three research aims. First, we will characterize polygenic influences on adolescent alcohol use among racially-ethnically diverse youth. Using a genome-wide polygenic score (PRS) approach, we will examine the effects of multiple adult and child-based PRS for alcohol and related traits (e.g., externalizing, internalizing symptoms) on timing of progression through the stages (e.g., experimentation, initiation, regular use, and problematic use), and trajectories of alcohol use from late childhood to adolescence. Second, we will examine the role of multiple childhood precursors (i.e., impulsivity, externalizing, and internalizing symptoms) in mediating polygenic influences on alcohol use. Finally, we will investigate the role of cultural-contextual risk and protective factors (i.e., parenting, peer deviance, stressful life events, racial discrimination experiences, familism cultural value) in moderating genetic influences on childhood precursors and adolescent alcohol use. We will explore how the associations of genetic, cultural-contextual factors, childhood precursors, and alcohol use change from late childhood to adolescence by examining age and developmental differences, and exploring differences by sex and pubertal status. Findings will advance alcohol and health disparities sciences by elucidating developmental and environmental mechanisms linking genetic risk to alcohol use among racially-ethnically diverse adolescents, providing critical insights for alcohol use prevention and intervention programs, including who is most at risk, what to target, and when to intervene.

项目摘要/摘要 酒精是美国最广泛使用的物质，也是统一的第三条主要可预防的死亡原因 国家。饮酒的起始通常发生在青少年中，早期发作（<15岁）的发作 与长时间的负面结果（例如AUD风险增加）有关。发展的发展 酒精使用和AUD受遗传和环境因素的影响，以及之间的复杂相互作用 他们（即基因 - 环境相互作用或g的）。然而，大多数遗传和G的研究是1） 由欧洲血统的人群进行，2）专注于 已经开始使用酒精或开发AUD。那就是对G的过程的了解有限 种族跨越种族的种群，以及遗传风险在发展中如何表现出来，以告知 早期预防和干预工作。此外，目的地文化是塑造的重要背景 在G的研究中，人类行为，文化风险和受保护因素在很大程度上被忽略了。我们寻求 提高对饮酒和饮酒的病因的理解，在大致不同的人群中 通过采取开发和文化知情的方法来研究gish过程。这个项目绘制数据 来自正在进行的青少年大脑和认知发展（ABCD）研究，其中包括丰富的基因组 和纵向样品的表型数据（n = 11,875; 52.1％白色，15.0％黑色和20.3％ 从童年后期（9-10岁）到种族多元化的孩子的西班牙裔/拉丁裔） 青少年。该项目考试三个研究目的。首先，我们将表征对多基因的影响 大致多样化的年轻人中的青少年饮酒。使用全基因组多基因评分（PRS） 方法，我们将研究多个成人和儿童PR对酒精和相关性状的影响（例如， 外在化，内在症状）在整个阶段的进展时间（例如，实验， 从童年晚期到青少年的启动，经常使用和有问题的使用）以及酒精使用的轨迹。 其次，我们将研究多个童年前体的作用（即冲动，外部化和 内化症状）介导对饮酒的多基因影响。最后，我们将调查 文化上下文的风险和保护因素（即育儿，同伴偏差，压力大的生活事件，种族 歧视经历，熟悉的文化价值）在适度的遗传影响对儿童前体的影响 和青春期饮酒。我们将探讨遗传，文化上下文因素的关联， 儿童前体和饮酒从儿童晚期到青少年的变化，通过检查年龄和 发展差异，并通过性别和青春期地位探索差异。调查结果将促进酒精 和健康分布科学，通过阐明联系遗传的发展和环境机制 在很少有多种多样的青少年中饮酒的风险，为酒精使用提供了关键的见解 预防和干预计划，包括谁最有风险，目标是什么以及何时进行干预。