High-Voltage Compact Capacitor for Implantable Defibrillator

用于植入式除颤器的高压紧凑型电容器

• 批准号: 7480846
• 负责人: BADAWI M DWEIK
• 金额: $ 14.92万
• 依托单位: GINER, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-17 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7480846
• 关键词: Address; Aluminum; American; American Heart Association; Anodes; Binding; Cardiac; Cells; Characteristics; Charge; Collaborations; Condition; Defibrillators; Devices; Electrolytes; Extravasation; Health; Heart; Heart Arrest; Hospitals; Housing; Implantable Defibrillators; Individual; Industry; Investigation; Life; Liquid substance; Manufacturer Name; Methods; Myocardial Infarction; Numbers; Paste substance; Patients; Phase; Polymers; Porosity; Procedures; Process; Public Health; Range; Risk; Safety; Series; Shapes; Shunt Device; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Solid; Standards of Weights and Measures; Sterilization for infection control; Structure; Sulfuric Acids; Survivors; Tantalum; Technology; Testing; Time; Weight; base; biomaterial compatibility; concept; cost; day; design; energy density; improved; innovation; millisecond; next generation; novel; programs; prototype; seal; size; tantalum oxide; voltage

DESCRIPTION (provided by applicant): High voltage Compact Capacitor for Implantable Defibrillator Worldwide, sudden cardiac arrest is a major health problem. The use of Implantable Cardioverter Defibrillators (ICD) has become an increasingly accepted treatment option, one that could save thousands of heart attack patients annually. With the increase in acceptance of these devices, the drive for improvement of ICD function and materials has intensified. The overall objective of the project program is to develop a new all solid high voltage capacitor type for the next generation of implantable defibrillators. This SBIR Phase I will demonstrate a novel and inexpensive method for the manufacture of an all-solid high energy density capacitor for ICD applications with higher operating voltages and volumetric energy densities. The objective is to increase the operating voltage of the existing Giner, Inc. high-voltage all-solid electrochemical-electrolytic capacitor. This will reduce the number of required capacitors inside the ICD from four to two, reduce the ICD weight and volume by replacing liquid electrolyte with solid electrolyte, permit use of a bipolar multi-cell series design to achieve high voltages, and, eliminate any possibility of shunt currents and electrolyte leakage, thereby enhancing reliability and safety. Prototype capacitor cells will be fabricated and characterized and tested. These units will be compared to standard capacitors to assess the overall benefit of the project. Packaging strategies will be developed and identified in collaboration with an industry leader. A unit capacitor will be fabricated and operated to demonstrate concept feasibility. Phase II will extend the investigation to optimize and standardize processes and designs to a) fabricate final cell stacks, evaluate capacitor housings, encapsulation materials, and procedures, b) perform long-term stability and biocompatibility tests, and to, c) study and select sterilization and packaging options. PUBLIC HEALTH RELEVANCE The use of Implantable Cardioverter Defibrillators (ICD) has become an increasingly accepted treatment option, one that could save thousands of heart attack patients annually. There is critical need for reduced size, high energy density capacitor for the ICD. Substantial reduction in the volume and consequently weight of the capacitor inside the ICD would represent a significant product improvement ICD resulting in many advantages for the patients.

描述（由申请人提供）：全球植入式除颤器的高压紧凑电容器，心脏骤停是一个主要的健康问题。使用植入式心脏扭曲器除颤器（ICD）已成为一种越来越接受的治疗选择，每年可以节省数千名心脏病发作患者。随着这些设备接受的增加，改善ICD功能和材料的动力加剧了。该项目计划的总体目标是为下一代可植入的除颤器开发新的所有实心高压电容器类型。该SBIR阶段I将展示一种新型且廉价的方法，用于制造全稳态的高能密度电容器，用于具有较高工作电压和大量能密度的ICD应用。目的是增加现有Giner，Inc。高压全稳态电化学电容电容器的工作电压。这将使ICD内部所需电容器的数量从四个减少到2，通过用固体电解液代替液体电解质，允许使用双极多电池系列设计来实现高压，并消除分流电流和电解质泄漏的任何可能性，从而减少ICD的重量和体积。原型电容器单元将被制造，表征和测试。这些单元将与标准电容器进行比较，以评估项目的整体收益。包装策略将与行业领导者合作制定和确定。单位电容器将被制造并操作以证明概念可行性。第二阶段将扩展研究以优化和标准化过程和设计a）a）a）制造最终的细胞堆栈，评估电容器壳体，封装材料和程序，b）进行长期稳定性和生物相容性测试，以及研究和研究和选择灭菌和包装选项。公共卫生相关性 使用植入式心脏扭曲器除颤器（ICD）已成为一种越来越接受的治疗选择，每年可以节省数千名心脏病发作患者。对于ICD的尺寸降低，高能密度电容器至关重要。 ICD内部电容器的体积和重量大大减少将代表ICD的重大改进，从而为患者带来许多优势。