High-Voltage Compact Capacitor for Implantable Defibrillator

用于植入式除颤器的高压紧凑型电容器

基本信息

批准号：
7925557
负责人：
BADAWI M DWEIK
金额：
$ 39.03万
依托单位：
GINER, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-03-17 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7925557
关键词：
Address Aluminum American American Heart Association Anodes Area Cardiac Cardiovascular system Caring Cathodes Cells Characteristics Charge Collaborations Corrosives Coupled Custom Defibrillators Development Devices Electric Capacitance Electric Countershock Electrolytes Engineering Ensure Evaluation Extravasation Failure Feasibility Studies Fiber Funding Goals Health Heart Heart Arrest Hospitals Housing Implantable Defibrillators Indium Individual Industry Investigation Lead Letters Life Light Liquid substance Maintenance Manufacturer Name Medical Metals Methods Myocardial Infarction Myocardium Patients Performance Phase Physiologic pulse Polymers Powder dose form Prevention Procedures Process Protocols documentation Public Health Reaction Research Design Safety Series Shapes Shunt Device Solid Sterilization Structure Sulfuric Acids Surface Survivors Tantalum Technology Testing Thick Time Tissues Water Weight Work base biomaterial compatibility cell type cost design energy density functional improvement high risk improved innovation medical specialties meetings millisecond miniaturize next generation novel operation prevent product development programs prototype public health relevance seal voltage

Address Aluminum American American Heart Association Anodes Area Cardiac Cardiovascular system Caring Cathodes Cells Characteristics Charge Collaborations Corrosives Coupled Custom Defibrillators Development Devices Electric Capacitance Electric Countershock Electrolytes Engineering Ensure Evaluation Extravasation Failure Feasibility Studies Fiber Funding Goals Health Heart Heart Arrest Hospitals Housing Implantable Defibrillators Indium Individual Industry Investigation Lead Letters Life Light Liquid substance Maintenance Manufacturer Name Medical Metals Methods Myocardial Infarction Myocardium Patients Performance Phase Physiologic pulse Polymers Powder dose form Prevention Procedures Process Protocols documentation Public Health Reaction Research Design Safety Series Shapes Shunt Device Solid Sterilization Structure Sulfuric Acids Surface Survivors Tantalum Technology Testing Thick Time Tissues Water Weight Work base biomaterial compatibility cell type cost design energy density functional improvement high risk improved innovation medical specialties meetings millisecond miniaturize next generation novel operation prevent product development programs prototype public health relevance seal voltage

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项目摘要

DESCRIPTION (provided by applicant): High Voltage Compact Capacitor for Implantable Defibrillator: Worldwide, sudden cardiac arrest is a major health problem. The use of Implantable Cardioverter Defibrillators (ICD) has become an increasingly accepted treatment option, one that could save thousands of heart attack patients annually. With the increase in acceptance of these devices, the drive for improvement of function and materials has intensified. One of the most critical and vital components of the ICD device is a high-voltage capacitor. The function of the capacitor is to store energy over a period of seconds and deliver it to the heart over a period of a few milliseconds. The overall goal of the proposed project is to develop an integrated and unitized (all elements in intimate contact), miniaturized, and all-solid high-voltage capacitor for the next generation of implantable defibrillators. The all-solid high-voltage capacitor is attractive because it can store several times as much energy as a conventional electrolytic capacitor, while retaining the ability to deliver that energy at high discharge rates. It will also allow the stacking of multi-cell units in series in the same package, something not possible in the case of the liquid electrolyte, which requires complicated packaging. This will reduce the number of required capacitors inside the ICD to two, reduce the ICD weight and volume by replacing liquid electrolyte with solid electrolyte, permit use of a bipolar multi-cell series design to achieve high voltages, and, eliminate any possibility of shunt currents and electrolyte leakage, thereby enhancing reliability and safety. The feasibility to develop an advanced miniaturized and all-solid high-voltage capacitor for the next generation of implantable defibrillators was demonstrated in Phase I. Improved tantalum anode formation processes enabled us to form anode components successfully at high voltages up to 350 V, which lead us to believe that even higher voltage can be achieved. During this Phase II program, it is proposed to build full-size 700-V stacks to be studied under long-term and accelerated test conditions. Based on the Phase I results, the technical approach for the Phase II product development program will include 1) further optimization of the tantalum anode structure b) fabricate final cell stacks, evaluate capacitor housings, encapsulation materials, and procedures, b) perform long-term stability and biocompatibility tests, and to, c) Study and select sterilization and packaging options. The successful completion of the Phase II project will result in a miniaturized capacitor and a method of fabricating a novel all-solid capacitor which will have applications for ICDs. PUBLIC HEALTH RELEVANCE: The use of Implantable Cardioverter Defibrillators (ICD) has become an increasingly accepted treatment option, one that could save thousands of heart attack patients annually. There is critical need for reduced size, high energy density capacitor for the ICD. Substantial reduction in the volume and consequently weight of the capacitor inside the ICD would represent a significant product improvement ICD resulting in many advantages for the patients.

描述（由申请人提供）：可植入式除颤器的高压紧凑电容器：全球，心脏骤停是一个主要的健康问题。使用植入式心脏扭曲器除颤器（ICD）已成为一种越来越接受的治疗选择，每年可以节省数千名心脏病发作患者。随着这些设备接受的增加，改善功能和材料的动力已经加剧。 ICD设备最关键和最重要的组件之一是高压电容器。电容器的功能是在几秒钟内存储能量，并在几毫秒内将其传递到心脏。拟议项目的总体目标是开发一个集成和统一的（亲密接触中的所有元素），微型化和全稳态的高压电容器，用于下一代可植入的除颤器。全稳态的高压电容器具有吸引力，因为它可以存储几倍的能量，同时保留以高排放速率传递该能量的能力。它还将允许以同一包装串联的多电池单元堆叠，如果液体电解质需要复杂的包装，这是不可能的。这将使ICD内部所需电容器的数量减少到两个，通过用固体电解质代替液体电解质，允许使用双极多电池系列设计来实现高压，并消除分流电流和电解质泄漏的任何可能性，从而增强可靠性和安全性。在第一阶段证明了为下一代植入式除颤器开发高级微型和全稳态的高压电容器的可行性。改进的斜阳极阳极形成过程使我们能够成功形成高电压下的阳极组件，使我们相信高达350 V，这使我们相信更高的电压能够达到更高的电压。在此II阶段计划中，建议在长期和加速的测试条件下建造全尺寸的700V堆栈。基于I期结果，II期产品开发计划的技术方法将包括1）进一步优化方不出望的阳极结构b）制造最终细胞堆栈，评估电容器外壳，包装材料和程序，b）执行长期稳定性和生物相容性测试，以及c）研究，c）研究，选择和选择灭菌和包装选项。成功完成II期项目将导致微型电容器和制造新型的全稳态电容器的方法，该电容器将用于ICD。公共卫生相关性：使用可植入的心脏逆转除颤器（ICD）已成为一种越来越接受的治疗选择，每年可以节省数千名心脏病发作患者。对于ICD的尺寸降低，高能密度电容器至关重要。 ICD内部电容器的体积和重量大大减少将代表ICD的重大改进，从而为患者带来许多优势。