Rapid and On-site Monitoring of Urinary Arsenic Metabolites

尿砷代谢物的快速现场监测

基本信息

批准号：
8714940
负责人：
BADAWI M DWEIK
金额：
$ 51.05万
依托单位：
GINER, INC.
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-19 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8714940
关键词：
Acids Algorithms Archives Arsenates Arsenic Arsenites Biological Markers Biological Monitoring Cacodylic Acid Cardiovascular Diseases Chelating Agents Chemicals Chronic Collaborations Communication Computer software Computers Data Analyses Detection Development Devices Diagnostic Electrodes Electronics Elements Ensure Epidemiologic Studies Evaluation Excision Exposure to Filtration Food Geometry Goals Gold Health Heavy Metals High Pressure Liquid Chromatography Malignant Neoplasms Measurement Measures Medical Methods Monitor Noise Outcome Phase Population Populations at Risk Procedures Process Protocols documentation Public Health Public Health Schools Readiness Reference Standards Reproducibility Resolution Risk Sampling Signal Transduction Site Small Business Innovation Research Grant Source System Systems Analysis Techniques Technology Testing Time Toxic effect Training Urine Validation Work computerized data processing cost design disorder prevention drinking water experience exposed human population improved instrument meetings monomethylarsonic acid novel oxidation professor programs prototype public health relevance response sensor tool urinary usability

项目摘要

DESCRIPTION (provided by applicant): Giner, Inc. proposes a portable, inexpensive, and rapid-response monitor for arsenic speciation in urine. Arsenic species excreted in urine are reflective of exposure to toxic arsenic species, and therefore this monitor will be a valuable tool in medical diagnostics and epidemiological studies by allowing determination of arsenic exposure by a technique that is faster and less expensive than traditional methods. Improved capability of monitoring exposure will have positive public health outcomes, as long- term exposure to arsenic is associated with health problems including cancer and cardiovascular disease. The phase I program developed a sensor capable of electrochemical detection of arsenic (III), total inorganic arsenic, and dimethylarsenic acid. Total organic arsenic was determined through a sample treatment process followed by electrochemical detection. The phase II program will include further optimization of all methods and processes, design of a prototype device, and validation of the device with real urine samples from epidemiological studies. The phase II program will result in a practical, robust, and accurate arsenic speciation device.

描述（由申请人提供）：Giner，Inc。提出了用于尿液中砷形成的便携式，廉价且快速响应监测仪。尿液中排出的砷物种反映了暴露于有毒砷的物种，因此该监测器将是一个有价值的工具在医学诊断和流行病学研究中，允许通过一种比传统方法更快且价格便宜的技术来确定砷暴露。提高监测暴露能力将带来积极的公共卫生结果，因为长期接触砷与包括癌症和心血管疾病在内的健康问题有关。 I期计划开发了一种能够对砷（III），总无机砷和二甲基苯甲酸的电化学检测的传感器。通过样本处理过程，然后进行电化学检测确定总有机砷。 II期计划将包括所有方法和过程的进一步优化，原型设备的设计以及通过流行病学研究中的真实尿液样本对设备进行验证。 II期计划将为实用，健壮和准确的砷形成型装置提供。