Field-Deployable Monitor to Assess Personal Exposure to Multiple Heavy Metals

可现场部署的监测器，用于评估个人对多种重金属的暴露情况

• 批准号: 7495592
• 负责人: BADAWI M DWEIK
• 金额: $ 29.95万
• 依托单位: GINER, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7495592
• 关键词: Algorithms; Archives; Area; Arsenic; Arsenicals; Biological; Biological Assay; Biological Monitoring; Blood; Boron; Breathing; Cadmium; Cadmium Compounds; Characteristics; Chemicals; Clinical; Collaborations; Complex; Condition; Coupled; Data; Data Display; Detection; Diamond; Dose; Electrodes; Environment; Environmental Pollutants; Evaluation; Exposure to; Food; Foundations; Health; Health protection; Heavy Metals; High Pressure Liquid Chromatography; Housing; Human; In Situ; Knowledge; Laboratories; Lead; Liquid substance; Mass Spectrum Analysis; Measurement; Measures; Mercury; Metals; Methods; Microcomputers; Monitor; Organism; Performance; Phase; Physiologic pulse; Plasma; Population; Process; Production; Public Health Schools; Pulse taking; Regulation; Reproducibility; Route; Sampling; Signal Transduction; Site; Solutions; Source; Specificity; Specimen; Standards of Weights and Measures; System; Techniques; Testing; Time; Toxic effect; Trace metal; Urine; Work; analytical method; aqueous; catalyst; comparative; cost; design; disorder prevention; drinking water; exposed human population; human tissue; instrument; microchip; pollutant; programs; prototype; research clinical testing; response; sensor; toxic metal

DESCRIPTION (provided by applicant) Numerous pollutant compounds are continuously released into the environment during their production, use and disposal. The resulting mixtures contaminate the environment and can be a potential threat to human beings. Heavy metals are significant environmental pollutants because they tend to persist in the environment, tend to bioaccumulate and can result in adverse health effects when ingested or inhaled. These metal species can be measured in human tissue or fluids such as blood or urine, usually in central laboratories using complex methods such as high-performance liquid chromatography inductively coupled plasma mass spectroscopy. However, in view of the high labor and analytical costs and long time delays associated with centralized laboratory analyses, there is an immediate need for a portable and inexpensive system for on-site monitoring of exposure to heavy metals in living systems, especially humans, as a result of exposure through drinking water, environmental, and industrial sources. Field deployable monitoring systems for in-situ, on-site, personal human exposure assessment will allow realtime monitoring of exposure to trace toxic metals, and facilitate the use of bio-monitoring data by allowing the instrument to be taken to the sample rather than the traditional way of bringing the sample to the laboratory. The overall objective of this project is to develop a portable, self-contained, easy-to-use monitor for simultaneous on-site measurement of arsenic, cadmium, mercury and lead metals from one urine sample, in near real time, to assess personal exposure. The proposed sensor will combine the high sensitivity of a specialized electrochemical measurement technique with a unique microarray electrode material and configuration. During Phase I, we will investigate sensor design configurations, electrode material composition, and the preliminary operating conditions which will demonstrate the feasibility of the unique microchip sensor prototype for detection of arsenic and cadmium species. At the conclusion of the Phase I/II program, a compact, packaged prototype sensor instrument will have been developed, tested and utilized in pilot epidemiological field trials.

描述（由申请人提供） 在生产，使用和处置期间，许多污染物化合物在其生产，使用和处置期间不断释放到环境中。由此产生的混合物污染了环境，可能是对人类的潜在威胁。重金属是重要的环境污染物，因为它们倾向于在环境中持续存在，倾向于生物蓄积，并且在摄入或吸入时会导致不利的健康影响。这些金属物种通常在人体组织或液体（例如血液或尿液）中进行测量，通常是在中央实验室中使用复杂的方法，例如高性能液相色谱，电感性等离子体质谱。但是，考虑到与集中实验室分析相关的高劳动力和分析成本以及长时间的延误，因此需要立即需要便携式且廉价的系统，以在现场监测生活系统中的重金属，尤其是人类中的重金属，例如通过饮用水，环境和工业来源暴露的结果。现场可部署的监视系统，用于现场，现场，个人接触评估，将允许实时监视有毒金属的曝光，并通过将仪器带入样品而不是样本，而不是使用生物监测数据来实现。将样品带入实验室的传统方式。 该项目的总体目的是开发一个便携式，独立的，易于使用的监视器，以同时对砷，镉，汞和铅金属进行现场测量，并在几乎实时评估一个尿液样本，以评估个人的个人评估。接触。提出的传感器将结合专门的电化学测量技术的高灵敏度与独特的微阵列电极材料和构型。在第一阶段，我们将研究传感器设计配置，电极材料组成和初步工作条件，这将证明独特的微芯片传感器原型用于检测砷和镉物种的可行性。在第I/II期计划的结论结束时，将在Pilot流行病学现场试验中开发，测试和使用紧凑的包装原型传感器仪器。