Selective Attention Mechanisms in Schizophrenia

精神分裂症的选择性注意机制

• 批准号: 6725944
• 负责人: Antigona Martinez
• 金额: $ 7.57万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6725944
• 关键词: attention deficit disorder; behavioral /social science research tag; brain electrical activity; clinical research; cognition disorders; electrodes; electroencephalography; electrophysiology; evoked potentials; functional magnetic resonance imaging; hemodynamics; human subject; neural information processing; neuroanatomy; neuroimaging; patient oriented research; schizophrenia; visual pathways; visual perception; visual stimulus

DESCRIPTION (provided by applicant): Attentional deficit is one of the root causes of the cognitive dysfunction and general impairments in information processing that are characteristic of persons afflicted with schizophrenia. When compared to the performance of normal adults, schizophrenia patients show pronounced deficits on psychophysical tasks requiring the allocation and/or maintenance of attention on behaviorally relevant information. Attention deficits in schizophrenia have been measured using a multitude of task and stimulus parameters. Many of these studies converge on the finding that the marked deficit in attention observed in schizophrenia patients may be related to a dysfunction within the neurophysiological visual pathways at an anatomically and temporally early stage of visual processing. Various psychophysical tasks have been used in order to evaluate processing deficits in the magnocellular and parvo-cellular visual pathways of schizophrenia patients. As a result, it has been proposed that schizophrenia is associated with preferential magnocellular/dorsal stream dysfunction. This project will utilize electrophysiological and functional neuroimaging measures of neural activity in order to delineate the neuroanatomical and temporal bases of selective visual attention deficits in schizophrenia patients and, in particular, how these relate to sensory processing within the magnocellular and parvo-cellular visual pathways.

描述（由申请人提供）：注意力不足是信息处理中认知功能障碍和一般损害的根本原因之一，这是患有精神分裂症的人的特征。与正常成年人的表现相比，精神分裂症患者在心理物理任务上表现出明显的缺陷，需要在行为相关信息上分配和/或维持注意力。精神分裂症的注意力缺陷已经使用多种任务和刺激参数测量。这些研究中的许多研究都融合了以下发现：精神分裂症患者观察到的注意力不足可能与在视觉处理的解剖和时间早期阶段在神经生理的视觉途径中的功能障碍有关。为了评估精神分裂症患者的巨细胞和细胞视觉途径的加工缺陷，已经使用了各种心理物理任务。结果，已经提出精神分裂症与优先的大细胞/背流功能障碍有关。该项目将利用神经活动的电生理和功能性神经影像学测量，以描绘精神分裂症患者中选择性视觉注意力缺陷的神经解剖学和时间基础，尤其是这些与磁细胞和parvo细胞细胞内部和parvo细胞内部视觉途径之间的感官处理。