Selective Attention Mechanisms in Schizophrenia

精神分裂症的选择性注意机制

• 批准号: 6830291
• 负责人: Antigona Martinez
• 金额: $ 7.68万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6830291
• 关键词: attention deficit disorder; behavioral /social science research tag; brain electrical activity; clinical research; cognition disorders; electrodes; electroencephalography; electrophysiology; evoked potentials; functional magnetic resonance imaging; hemodynamics; human subject; neural information processing; neuroanatomy; neuroimaging; patient oriented research; schizophrenia; visual pathways; visual perception; visual stimulus

DESCRIPTION (provided by applicant): Attentional deficit is one of the root causes of the cognitive dysfunction and general impairments in information processing that are characteristic of persons afflicted with schizophrenia. When compared to the performance of normal adults, schizophrenia patients show pronounced deficits on psychophysical tasks requiring the allocation and/or maintenance of attention on behaviorally relevant information. Attention deficits in schizophrenia have been measured using a multitude of task and stimulus parameters. Many of these studies converge on the finding that the marked deficit in attention observed in schizophrenia patients may be related to a dysfunction within the neurophysiological visual pathways at an anatomically and temporally early stage of visual processing. Various psychophysical tasks have been used in order to evaluate processing deficits in the magnocellular and parvo-cellular visual pathways of schizophrenia patients. As a result, it has been proposed that schizophrenia is associated with preferential magnocellular/dorsal stream dysfunction. This project will utilize electrophysiological and functional neuroimaging measures of neural activity in order to delineate the neuroanatomical and temporal bases of selective visual attention deficits in schizophrenia patients and, in particular, how these relate to sensory processing within the magnocellular and parvo-cellular visual pathways.

描述（由申请人提供）：注意力缺陷是认知功能障碍和信息处理一般障碍的根本原因之一，这是精神分裂症患者的特征。与正常成年人的表现相比，精神分裂症患者在心理物理任务上表现出明显的缺陷，需要分配和/或维持对行为相关信息的注意力。精神分裂症的注意力缺陷是通过多种任务和刺激参数来测量的。许多这些研究都集中在以下发现上：在精神分裂症患者中观察到的明显注意力缺陷可能与视觉处理的解剖学和时间早期阶段的神经生理视觉通路功能障碍有关。已使用各种心理物理任务来评估精神分裂症患者的大细胞和细细胞视觉通路的处理缺陷。因此，有人提出精神分裂症与优先的大细胞/背流功能障碍有关。该项目将利用神经活动的电生理学和功能性神经影像测量来描述精神分裂症患者选择性视觉注意缺陷的神经解剖学和时间基础，特别是这些与大细胞和细细胞视觉通路内的感觉处理的关系。