Functional Brain Mapping in Schizophrenia

精神分裂症的脑功能图谱

基本信息

批准号：
7406745
负责人：
Antigona Martinez
金额：
$ 15.67万
依托单位：
NATHAN S. KLINE INSTITUTE FOR PSYCH RES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-15 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7406745
关键词：
Applications Grants Area Brain Brain Mapping Diagnostic Disease Dorsal Eye Functional Magnetic Resonance Imaging Functional disorder Health system Image Impairment Individual Lead Location Magnetic Resonance Imaging Maps Masks Measures Methods Motion Motion Perception Participant Patients Personal Satisfaction Photic Stimulation Predisposition Process Psychophysiology Public Health Relative (related person)Resolution Schizophrenia Sensory Process Staging Standards of Weights and Measures Stimulus Stream Surface System Techniques Testing Three-Dimensional Image Variant Visual Visual Cortex Visual Pathways Visual system structure area MT base behavior measurement design extrastriate visual cortex hemodynamics improved magnocellular neurophysiology novel parvocellular reconstruction relating to nervous system response retinotopic visual process visual processing visual stimulus

Applications Grants Area Brain Brain Mapping Diagnostic Disease Dorsal Eye Functional Magnetic Resonance Imaging Functional disorder Health system Image Impairment Individual Lead Location Magnetic Resonance Imaging Maps Masks Measures Methods Motion Motion Perception Participant Patients Personal Satisfaction Photic Stimulation Predisposition Process Psychophysiology Public Health Relative (related person)Resolution Schizophrenia Sensory Process Staging Standards of Weights and Measures Stimulus Stream Surface System Techniques Testing Three-Dimensional Image Variant Visual Visual Cortex Visual Pathways Visual system structure area MT base behavior measurement design extrastriate visual cortex hemodynamics improved magnocellular neurophysiology novel parvocellular reconstruction relating to nervous system response retinotopic visual process visual processing visual stimulus

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项目摘要

DESCRIPTION (provided by applicant): Sensory processing deficits constitute a central feature of schizophrenia. In the visual system, these deficits have typically been investigated using psychophysical and behavioral measures. The findings from many of these studies converge to show that schizophrenia patients, relative to healthy control subjects, have increased susceptibility to visual backward masking (VBM), impaired motion perception and eye tracking deficits. The primary aim of the current application is to apply novel hemodynamic measures of brain activity in parallel with three-dimensional images of the rendered cortical surface to systematically map sensory processing areas in schizophrenia. Our aim is to use these maps to visualize the precise location of cortical activity in response to many types of visual stimuli given to one subject. Functionally defining visual processing areas is an important and necessary first step towards gaining a more complete understanding of the neurophysiological and anatomical bases of visual pathway dysfunction in schizophrenia. A secondary aim of the proposed study is to acquire preliminary information regarding dysfunction within the magnocellular (dorsal) visual processing stream in schizophrenia. Dorsal stream dysfunction has been well documented in schizophrenia and increasing evidence suggests that these deficits are due to low-level magnocellular dysfunction. The final study in this application will evaluate magnocellular and parvocellular function in schizophrenia using functional MRI (fMRI). Understanding the integrity of the visual pathways is crucial to understanding high-level visual dysfunction in schizophrenia. Schizophrenia is a devastating disease that significantly impacts the public health system. Understanding the basic brain mechanisms that underlie this disorder is an important and necessary step towards gaining a more complete understanding of the disease and may lead to improved treatment strategies.

描述（由申请人提供）：感觉处理缺陷构成精神分裂症的主要特征。在视觉系统中，这些缺陷通常是使用心理物理和行为指标研究的。这些研究中的许多研究结果表明，相对于健康对照对象的精神分裂症患者对视觉向后掩盖（VBM）的敏感性增加了，运动感知受损和眼动追踪缺陷。当前应用的主要目的是与渲染的皮质表面的三维图像并行采用新型的脑活动血液动力学测量，以系统地绘制精神分裂症的感觉处理区域。我们的目的是使用这些地图来可视化皮质活动的精确位置，以响应一个对一个受试者提供的许多类型的视觉刺激。在功能上定义视觉处理区域是对精神分裂症的视觉途径功能障碍的神经生理学和解剖基础的更完整理解的重要第一步。拟议的研究的第二个目的是获取有关精神分裂症中大细胞（背）视觉处理流中有关功能障碍的初步信息。在精神分裂症中，背面功能障碍已得到充分证明，越来越多的证据表明这些缺陷是由于低级巨细胞功能障碍所致。该应用中的最终研究将使用功能性MRI（fMRI）评估精神分裂症中的大细胞和细胞细胞功能。了解视觉途径的完整性对于理解精神分裂症中高级视觉功能障碍至关重要。精神分裂症是一种毁灭性疾病，对公共卫生系统产生了重大影响。了解这种疾病构成的基本大脑机制是对疾病更加完整理解的重要而必要的步骤，并可能导致改进的治疗策略。