Colliculopulvinar contributions to alpha dysregulation and cognitive dysfunction in schizophrenia

丘枕对精神分裂症阿尔法失调和认知功能障碍的影响

基本信息

批准号：
10388226
负责人：
Antigona Martinez
金额：
$ 24.59万
依托单位：
NATHAN S. KLINE INSTITUTE FOR PSYCH RES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10388226
关键词：
Anatomy Area Attention Attention deficit hyperactivity disorder Basic Science Behavioral Brain Bypass Cell Nucleus Characteristics Clinical Cognition Cognitive Complex Consensus Data Data Analyses Disease Electroencephalography Etiology Evaluation First Degree Relative Frequencies Functional Magnetic Resonance Imaging Functional disorder Future Gender Generations Genetic Glean Impaired cognition Impairment Lateral Lateral Geniculate Body Link Literature MATRICS Consensus Cognitive Battery Medial Mediating Mental disorders Modeling Mood Disorders Neurocognitive Deficit Occipital lobe Outcome Pathway interactions Patients Physiological Population Process Property Psychometrics Psychoses Public Health Pulvinar structure Research Retina Scalp structure Schizophrenia Sensory Short-Term Memory Side Stimulus Structural defect Suggestion System Testing Thalamic structure Time Visual Visual Cortex Visual Pathways Visual attention Visual impairment Visual system structure area striata autism spectrum disorder base cognitive function cognitive performance experimental study functional MRI scan functional magnetic resonance imaging/electroencephalography information processing magnocellular neural correlate neuropsychiatric disorder neuropsychiatry parvocellular response retinotectal severe psychiatric disorder superior colliculus Corpora quadrigemina tool transmission process vigilance visual information visual learning visual memory visual processing

项目摘要

Schizophrenia (Sz) is a severe psychiatric disorder associated with core neurocognitive deficits. Although, traditional models of schizophrenia focus on dysfunction within cognitive and sensory processing cortical regions, increasing evidence has accumulated suggestive of subcortical processing impairments as well. Deficits along the subcortical visual pathways, especially involving the magnocellular visual pathway, have been tied to deficits in the generation of early cortical responses which, in turn, contribute to higher-order cortical impairments. These deficits, however, may not account for all visual information processing abnormalities in Sz. Recently, we have observed deficits in the modulation of ongoing scalp- recorded alpha activity, which appear independent of the traditional magno/parvocellular pathways, and which may be mediated by dysfunction of the “retinotectal” visual pathway, which involves the superior colliculus (SC) and the pulvinar nucleus of the thalamus (PuN), but which bypasses the lateral geniculate nucleus (LGN). At present, tools for the evaluation of the retinotectal system within neuropsychiatric populations remain limited. In this project we will conduct a side-by-side comparison of potential paradigms gleaned from the basic science literature to elicit PuN/SC activation and will study their feasibility and psychometric properties. These paradigms will then be used to assess the integrity of PuN/SC processing in Sz relative to alpha generation and cognitive performance.

精神分裂症（Sz）是一种与核心神经认知功能相关的严重精神疾病尽管如此，传统的精神分裂症模型关注的是认知和功能障碍。感觉处理皮层区域，越来越多的证据表明皮质下视觉通路也有缺陷。特别是涉及大细胞视觉通路的疾病，与早期皮质反应的产生，反过来又有助于高阶皮质然而，这些缺陷可能无法解释所有的视觉信息处理。最近，我们观察到持续头皮调节的缺陷。记录的 α 活性，似乎独立于传统的大细胞/小细胞通路，这可能是由“视网膜顶盖”视觉通路的功能障碍介导的，涉及上丘 (SC) 和丘脑枕核 (PuN)，但其中绕过外侧膝状核（LGN）目前，用于评估的工具。神经精神人群中的视网膜顶盖系统仍然有限。对从基础科学中收集到的潜在范式进行并排比较文献来引发 PuN/SC 激活，并将研究其可行性和心理测量特性。然后，这些范例将用于评估 PuN/SC 处理在 Sz 相对值中的完整性。阿尔法生成和认知表现。