Colliculopulvinar contributions to alpha dysregulation and cognitive dysfunction in schizophrenia

丘枕对精神分裂症阿尔法失调和认知功能障碍的影响

基本信息

批准号：
10218383
负责人：
Antigona Martinez
金额：
$ 20.49万
依托单位：
NATHAN S. KLINE INSTITUTE FOR PSYCH RES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10218383
关键词：
Anatomy Area Attention Attention deficit hyperactivity disorder Basic Science Behavioral Brain Bypass Cell Nucleus Characteristics Clinical Cognition Cognitive Complex Consensus Data Data Analyses Disease Electroencephalography Etiology Evaluation First Degree Relative Frequencies Functional Magnetic Resonance Imaging Functional disorder Future Gender Generations Genetic Glean Impaired cognition Impairment Lateral Lateral Geniculate Body Link Literature Medial Mediating Mental disorders Modeling Mood Disorders Neurocognitive Deficit Occipital lobe Outcome Pathway interactions Patients Physiological Population Process Property Psychometrics Psychoses Public Health Pulvinar structure Research Retina Scalp structure Schizophrenia Sensory Short-Term Memory Side Stimulus Structural defect Suggestion System Testing Thalamic structure Time Visual Visual Cortex Visual Pathways Visual attention Visual impairment Visual system structure area striata autism spectrum disorder base cognitive function cognitive performance experimental study functional MRI scan functional magnetic resonance imaging/electroencephalography information processing magnocellular neural correlate neuropsychiatric disorder neuropsychiatry parvocellular response retinotectal severe psychiatric disorder superior colliculus Corpora quadrigemina tool transmission process vigilance visual information visual learning visual memory visual processing

项目摘要

Schizophrenia (Sz) is a severe psychiatric disorder associated with core neurocognitive deficits. Although, traditional models of schizophrenia focus on dysfunction within cognitive and sensory processing cortical regions, increasing evidence has accumulated suggestive of subcortical processing impairments as well. Deficits along the subcortical visual pathways, especially involving the magnocellular visual pathway, have been tied to deficits in the generation of early cortical responses which, in turn, contribute to higher-order cortical impairments. These deficits, however, may not account for all visual information processing abnormalities in Sz. Recently, we have observed deficits in the modulation of ongoing scalp- recorded alpha activity, which appear independent of the traditional magno/parvocellular pathways, and which may be mediated by dysfunction of the “retinotectal” visual pathway, which involves the superior colliculus (SC) and the pulvinar nucleus of the thalamus (PuN), but which bypasses the lateral geniculate nucleus (LGN). At present, tools for the evaluation of the retinotectal system within neuropsychiatric populations remain limited. In this project we will conduct a side-by-side comparison of potential paradigms gleaned from the basic science literature to elicit PuN/SC activation and will study their feasibility and psychometric properties. These paradigms will then be used to assess the integrity of PuN/SC processing in Sz relative to alpha generation and cognitive performance.

精神分裂症（SZ）是一种与核心神经认知有关的严重精神病缺陷。感觉处理皮质区域，越来越多的证据积累了暗示皮层处理障碍也是如此。沿着皮层视觉途径的缺陷，特别涉及的磁性视觉途径已被绑定以定义早期皮质反应的产生又有助于高阶皮质障碍。但是，这些定义可能无法说明所有视觉信息处理 SZ异常。最近，我们观察到正在调制正在进行的头皮的调制中的缺陷记录的α活性，似乎独立于传统的磁/副细胞途径，并且可以通过“视网膜直肠”视觉途径的功能障碍来介导该途径涉及丘脑的上丘（SC）和丘脑核（pun），但绕过侧向元素核（LGN）。目前，用于评估的工具神经精神病学种群中的视网膜直肠系统仍然有限。在这个项目中，我们将对基础科学收集的潜在范例进行并排比较引起双关语/SC激活的文献，并将研究其可行性和心理测量特性。然后，这些范例将用于评估SZ相对的双关语/SC处理的完整性到Alpha的产生和认知表现。