Study of Peripheral Immune Effects and Pathway on Brain

脑周围免疫效应及通路研究

• 批准号: 6643043
• 负责人: HAL C CANTOR
• 金额: $ 10万
• 依托单位: ADVANCED SENSOR TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-04 至 2003-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6643043
• 关键词: adrenocorticotropic hormone; biomedical equipment development; bioreactors; cell cell interaction; corticotropin releasing factor; cytokine; endorphins; gonadotropin releasing factor; immune system; neuroendocrine system; neuroimmunomodulation; peripheral nervous system; vasopressins

DESCRIPTION (provided by applicant): There exists a growing body of evidence, both experimental and clinical, which supports the concept of intimate communication between the central nervous and immune systems to maintain homeostasis and health. Data support the fact that this interrelationship is bi-directional, such that the immune system is subject to regulation by neuroendocrine factors and vice versa. Advanced Sensor Technologies, Inc (AST) proposes to combine a number of its existing proprietary technologies to create a sensor-fitted, modular, perifusion bioreactor to perform in vitro studies to better understand and elucidate these means of cellular communication. Since AST's modular perifusion bioreactor is capable of closely mimicking in vivo conditions in vitro, the intimate communication between the nervous, endocrine, and immune systems can be elucidated. The results of this proposed research and development project will provide: (a) a commercially viable bioreactor platform that will be utilized first by the research communities (universities) followed by the development communities (drug discovery companies); (b) basic scientific insight into the axes of cellular communication. AST's sensor-fitted, modular, perifusion bioreactor is capable of monitoring the concentrations of a wide variety of biological molecules, including neurohormones such as arginine vasopressin, corticotropin releasing factor, gonadotropin releasing hormone, and beta-endorphin.

描述（由申请人提供）：存在越来越多的实验和临床证据，这支持了中枢神经和免疫系统之间亲密沟通的概念，以维持稳态和健康。数据支持以下事实：这种相互关系是双向的，因此免疫系统受神经内分泌因素的调节，反之亦然。 Advanced Sensor Technologies，Inc（AST）建议将其许多现有的专有技术结合起来，以创建传感器拟合的，模块化的，炎性的生物反应器，以进行体外研究，以更好地理解和阐明这些细胞通信方式。由于AST的模块化促进性生物反应器能够在体外模仿体外情况，因此可以阐明神经，内分泌和免疫系统之间的亲密通信。该拟议的研发项目的结果将提供：（a）一个商业上可行的生物反应器平台，将首先被研究社区（大学）使用，其次是开发社区（药物发现公司）； （b）对细胞通信轴的基本科学见解。 AST拟合的模块化，炎性生物反应器能够监测各种生物分子的浓度，包括神经激素，例如精氨酸加压素，皮质激素释放因子，促性腺激素释放的激素释放激素和β-肾上腺素。