Real-Time Melatonin Monitor to Diagnose Sleep Disorders

实时褪黑激素监测仪诊断睡眠障碍

• 批准号: 6401739
• 负责人: HAL C CANTOR
• 金额: $ 9.96万
• 依托单位: ADVANCED SENSOR TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-19 至 2002-03-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6401739
• 关键词: aging; biomedical equipment development; blood chemistry; clinical biomedical equipment; clinical research; consumable /disposable biomedical equipment; human subject; mass screening; melatonin; noninvasive diagnosis; nontherapeutic iontophoresis; patient monitoring device; semiconduction; sleep disorders; technology /technique development; time resolved data; transdermal drug delivery

With an ever-growing elderly population, it is becoming increasingly important to monitor physiological correlates associated with age. One major problem associated with age revolves around quantity and quality of sleep. Many commercial devices monitor physiometric nocturnal activity (i.e. actigraphy, EEG, EMG, EOG, respiration, etc.), however, there are no commercial devices available for continuous, non-invasive, near real-time monitoring of chemicals in the blood. The pineal hormone, melatonin, follows a characteristic circadian temporal pattern. Plasma melatonin concentrations are utilized as a correlate indicating sleep, and exogenous application has been utilized in the attempt to improve the quality and quantity of sleep. Contemporary studies on the causal effects of melatonin on sleep require drawing of blood, saliva, or urine, however, each of these techniques require effort on the part of the subject, causing deviation from normal sleep patterns. AST proposes to develop a continuous, near real-time, non-invasive monitor for blood borne chemicals, including melatonin (as well as a myriad of other biological molecules), obtained during activity or sleep. This device will be amenable to mass screening of the elderly (and pediatric) population, with the potential for actuator regulated exogenous melatonin administration. PROPOSED COMMERCIAL APPLICATIONS: In addition to utilization for the study of sleep disorders in elderly patients, this device has the potential to monitor concentrations of electrolytes, hormones, therapeutic drugs, drugs of abuse, and environmental toxins in active ambulatory adults and children. Semiconductor manufacture is amenable to mass production at very low cost. This disposable device will be available for the clinical and home health care markets. Long term sales are estimated to be in the millions per year.

随着老年人的不断增长，监测与年龄相关的生理相关性变得越来越重要。与年龄相关的一个主要问题围绕数量和睡眠质量。但是，许多商业设备监测了物理夜间活动（即Actraphy，EEG，EMG，EOG，呼吸等）。松果激素褪黑激素遵循特征性的昼夜节律图案。血浆褪黑激素浓度被用作指示睡眠的相关性，并且已利用外源性应用来提高睡眠的质量和数量。当代研究褪黑激素对睡眠的因果作用需要抽取血液，唾液或尿液，但是，这些技术中的每一种都需要受试者的努力，从而导致与正常睡眠模式的偏离。 AST建议在活动或睡眠期间获得一个连续的，几乎实时的非侵入性监测化学物质，包括褪黑激素（以及无数其他生物分子）。该装置将适合对老年人（和小儿）种群进行大规模筛查，并有可能执行执行的外源褪黑激素给药。拟议的商业应用：除了用于研究老年患者睡眠障碍的利用外，该装置还具有监测电解质，激素，治疗药物，滥用药物和活跃的卧床成人和儿童的环境毒素的潜力。半导体制造可以以非常低的成本来调整大规模生产。该一次性设备将用于临床和家庭保健市场。长期销售估计为每年数百万。