Personal Monitor to Detect Exposure to Toxic Agents

用于检测有毒剂暴露情况的个人监视器

• 批准号: 6791356
• 负责人: HAL C CANTOR
• 金额: $ 43.1万
• 依托单位: ADVANCED SENSOR TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-13 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6791356
• 关键词: biomedical equipment development; bioterrorism /chemical warfare; blood toxicology; carbamates; cholinesterases; clinical research; computer system design /evaluation; enzyme activity; erythrocytes; human subject; insecticides; monitoring device; neurotoxins; plasma

DESCRIPTION (provided by applicant): Advanced Sensor Technologies, Inc. (AST) proposes to continue its NIH funded Phase I efforts to develop a completely automated miniaturized device capable of monitoring different types of cholinesterases from a single drop of whole blood to determine the degree of exposure of an individual to organophosphate (OP) compounds or carbamates. This device will be amenable to mass screening of pesticide workers, persons in direct contact with OP compounds, as well as soldiers and civilians potentially exposed to chemical warfare agents. Towards these goals, AST has developed a passive first generation micro-electro-mechanical system (MEMS) based prototype with integrated fluid acquisition and external monitoring system, and has performed tests to prove its feasibility in monitoring cholinesterase activity. AST is requesting Phase II funding to improve the Phase I prototype and develop a commercially available, completely automated device, suitable for the general population. Cholinesterase activity in blood is affected by OP compounds and carbamates, with the level of exposure inversely proportional to the toxin concentration or activity. Different types of cholinesterases are located in plasma and red blood cells, and monitoring these blood enzymes automatically, in finger-prick samples of blood, by an untrained individual, will require miniaturization and integration of several different components.

描述（由申请人提供）：高级传感器Technologies，Inc。（AST）提议继续其NIH资助的第一阶段努力，以开发一种完全自动化的小型化设备，能够从一滴全血中监测不同类型的胆碱酯酶以确定该程度个体暴露于有机磷酸盐（OP）化合物或氨基甲酸酯。该设备将适合大规模筛查农药工人，与OP化合物直接接触的人以及可能接触化学战代理商的士兵和平民。朝向这些目标，AST开发了一种被动的第一代微电力系统（MEMS）的原型，具有集成的流体采集和外部监测系统，并进行了测试以证明其在监测胆碱酯酶活动方面的可行性。 AST要求II阶段资金改善I期原型，并开发出适合普通人群的市售，完全自动化的设备。血液中的胆碱酯酶活性受OP化合物和氨基甲酸酯的影响，其暴露水平与毒素浓度或活性成反比。不同类型的胆碱酯酶位于血浆和红细胞中，并通过未经训练的个体自动监测这些血液的血液样本将需要微型化和整合几种不同的成分。