MULTISITE POTENTIO/AMPEROMETRIC NEURAL SENSOR ARRAY

多点电位/电流神经传感器阵列

• 批准号: 2715531
• 负责人: HAL C CANTOR
• 金额: $ 10万
• 依托单位: ADVANCED SENSOR TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2715531
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biosensor device; clinical biomedical equipment; electrical measurement; electrophysiology; method development; nervous system prosthesis; neurotransmitters; potentiometry

DESCRIPTION: Advanced Sensor Technologies, Inc. proposes to develop a multi-site neural sensor array, consisting of microscopic arrays of interspersed potentiometric and amperometric sensors grown on silicon wafers using CMOS technology. The sensor array will be capable of multi-unit neural potentiometric recording with concomitant rapid neurotransmitter release, degradation, and re-uptake analysis via voltammetric sensor technology. Our Phase-II goals include incorporation of potentiostat, amperometer, and actuator controllers directly on the sensor substrate to provide closed-loop control of devices based upon voluntary and involuntary neural output. Our ultimate vision is a self-contained miniature neural prosthetic device which can provide autonomic and voluntary functions in persons with brain injuries/defects, spinal cord injuries, and sensory organ deficits. PROPOSED COMMERCIAL APPLICATION: The proposed multisite potentiometric/amperometric sensor array has the potential to serve as the transduction interface for neural prostheses. Additionally, the sensor array may be employed in scientific investigations into the electrochemical mechanisms of neural activity.

描述：Advanced Sensor Technologies, Inc. 提议开发一种 多位点神经传感器阵列，由微观阵列组成 在硅上生长的散布电位和电流传感器 采用 CMOS 技术的晶圆。 传感器阵列将能够 多单元神经电位记录伴随快速 神经递质释放、降解和再摄取分析 伏安传感器技术。 我们的第二阶段目标包括整合恒电位仪、电流计、 和执行器控制器直接在传感器基板上提供 基于自愿和非自愿的设备闭环控制 神经输出。 我们的最终愿景是一个独立的微型神经网络 能够提供自主和随意功能的假肢装置 患有脑损伤/缺陷、脊髓损伤的人，以及 感觉器官缺陷。 拟议的商业应用： 所提出的多点电位/电流传感器阵列具有 作为神经假体的转导接口的潜力。 此外，传感器阵列可用于科学领域 研究神经活动的电化学机制。