Power Harvesting in Implanted Neural Probes

植入神经探针中的能量收集

• 批准号: 7099376
• 负责人: NITISH VYOMESH THAKOR
• 金额: $ 19.42万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7099376
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biosensor device; biotechnology; brain electrical activity; cerebral ischemia /hypoxia; disease /disorder model; glutamates; implant; laboratory rat; medical implant science; microelectrodes; miniature biomedical equipment; monitoring device; neurochemistry; neurophysiology; nitric oxide

DESCRIPTION (provided by applicant): This is an interdisciplinary, innovative technology research and demonstration project to develop the next generation of neural probes for implanted recording. Current neural probes record electrical signals with the use of multiple silicon micromachined electrodes. In an advancement in this field, supported by previous NIH funding, we have demonstrated miniature neurochemical sensors and developed the specialized VLSI integrated circuitry needed to enable chemical measurements from multiple electrodes in a microprobe assembly. The next challenge is to research methods to harvest power to energize the implanted sensor and circuitry. Towards this goal, we propose two innovative technologies 1) the development of a rechargeable, microbattery system capable of sustaining power to the sensor and circuitry, 2) development of a novel VLSI wireless power harvesting circuit to energize the battery. Our other aims are to 3) develop an integrated probe with neurochemical sensor, VLSI wireless interface, power harvesting circuit and microbattery, and 4) evaluate the probe in a model of global ischemic brain injury. This research contributes to our long term goal to build fully implantable, autonomous microprobes, without any tethering, for neurochemical recording in chronically instrumented and tether less animals. A fully self-powered implanted neural microprobe system will be an enabling tool in the hands of neuroscientists interested in recording neural activity from animal models of brain function or brain disorders with the use of microelectrode arrays.

描述（由申请人提供）：这是一个跨学科的创新技术研究和演示项目，旨在开发下一代的植入记录的神经探针。 电流神经探针通过使用多个硅微机械电极记录电信号。 在以前的NIH资金支持下，在该领域的进步中，我们展示了微型神经化学传感器，并开发了可从微螺旋桨组件中的多个电极实现化学测量所需的专门VLSI集成电路。 下一个挑战是研究方法，以收获能量，以供应植入的传感器和电路。 为了实现这一目标，我们提出了两种创新的技术1）开发可充电的微生物系统，能够维持传感器和电路的功率，2）开发新型的VLSI无线功率收集电路以使电池充满电。 我们的另一个目的是3）使用神经化学传感器，VLSI无线界面，功率收集电路和微生物以及4）在全球缺血性脑损伤模型中评估探针。 这项研究为我们的长期目标做出了贡献，以建立完全可植入的，自主的微探针，而无需任何束缚，以在长期仪器和束缚的动物中进行神经化学记录。 完全自动的植入神经微探针系统将是有助于通过使用微电极阵列记录脑功能动物或脑部疾病的动物模型的神经活动的神经科学家手中的一种促成工具。