Personal Monitor to Detect Exposure to Toxic Agents

用于检测有毒剂暴露情况的个人监视器

• 批准号: 6482680
• 负责人: HAL C CANTOR
• 金额: $ 9.99万
• 依托单位: ADVANCED SENSOR TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-13 至 2002-11-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6482680
• 关键词: acetylcholinesterase; bioengineering /biomedical engineering; biomedical equipment development; biosensor device; blood chemistry; carbamates; cholinesterases; environmental exposure; hazardous substances; miniature biomedical equipment; monitoring device; occupational health /safety; organophosphorus insecticide

DESCRIPTION (Applicant's abstract): Toward the goal of developing an automated, miniaturized device to detect the body's reaction to exposure to environmental toxins, Advanced Sensor Technologies, Inc. proposes to develop a miniature device capable of providing differential blood cholinesterase analysis. The device will provide analysis of cholinesterase levels (acetylcholinesterase and butyrylcholinesterase) using a single drop of blood obtained from finger prick sampling. The system will be automated such that it may be utilized by minimally trained individuals, and will provide results in less than five minutes. The proposed device will provide health clinics with units capable of screening and confirming exposure of lawn care worker, crop dusters, athletes, and first responders (i.e. EMS personnel) to chemical agents, pesticides, or other toxic chemicals. It has been demonstrated that these, and other drugs, especially those that are organophosphorous or carbamate based, inhibit cholinesterase (ChE) activity in human blood. These inhibitory effects often persist for up to 100 days in a healthy individual after exposure. Additionally, the device, designed similarly to home pregnancy tests, can be utilized by parents to test their children for exposure to environmental toxins, including pesticides on insufficiently washed fruits and vegetables. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（申请人的摘要）：旨在开发自动化的目标， 微型化装置，以检测人体对环境暴露的反应 毒素，高级传感器Technologies，Inc。提议开发微型 能够提供差异血液胆碱酯酶分析的装置。这 设备将提供胆碱酯酶水平（乙酰胆碱酯酶和 丁酰胆碱酯酶）使用从手指刺获得的一滴血液 采样。该系统将是自动化的，以便可以通过 受过最小训练的个人，并将提供少于五个的结果 分钟。 提出的设备将为健康诊所提供能够筛查的单位 并确认草坪护理人员，农作物dusters，运动员和第一 响应者（即EMS人员）对化学剂，农药或其他有毒 化学物质。已经证明了这些，尤其是其他药物 那些基于有机磷或氨基甲酸酯的人，抑制胆碱酯酶 （CHE）人类血液中的活性。这些抑制作用通常会持续 暴露后健康的人100天。此外，设备， 与家庭怀孕测试相似的设计，父母可以使用 他们的孩子接触环境毒素，包括农药 洗涤水果和蔬菜不足。 拟议的商业应用程序：不可用