Center of Biomedical Research Excellence in Matrix Biology Phase II

基质生物学卓越生物医学研究中心第二期

• 批准号: 10397810
• 负责人: JULIA THOM OXFORD
• 金额: $ 22.17万
• 依托单位: BOISE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10397810
• 关键词: Achievement; Address; Administrative Supplement; Award; Bioinformatics; Biology; Biomedical Engineering; Biomedical Research; Biometry; Bioreactors; Cell Nucleus; Cells; Centers of Research Excellence; Chemistry; Collaborations; Computer Analysis; Computer software; Core Facility; Data Analyses; Development; Development Plans; Discipline; Disease; Disease Progression; Education; Electrical Engineering; Engineering; Environment; Experimental Designs; Extracellular Matrix; Fee-for-Service Plans; Fostering; Foundations; Funding; Future; Goals; Grant; Growth; Health; Histology; Human Resources; Idaho; Image; Individual; Institution; Interdisciplinary Study; Journals; Laboratories; Maintenance; Mass Spectrum Analysis; Mechanics; Medical center; Mentors; Microscopy; National Institute of General Medical Sciences; Natural regeneration; Nature; Parents; Peer Review; Peer Review Grants; Phase; Physics; Prevention; Proteomics; Publications; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Role; Running; Science; Services; Students; Therapeutic; Tissues; Training; Universities; Veterans; Visualization; career development; college; computer science; cyber infrastructure; data acquisition; disease diagnosis; equipment acquisition; experimental study; imaging system; improved; instrument; instrumentation; live cell imaging; materials science; metabolomics; microscopic imaging; models and simulation; multidisciplinary; operation; programs; repaired; success; symposium; therapeutic development; tissue regeneration; tissue repair; training opportunity

Project Summary/Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) in Matrix Biology is to establish, enhance, and actively advance a multidisciplinary research center focusing on improving our understanding of the role of the extracellular matrix in development, health, and disease, and contributing to the prevention, treatment, and cure for diseases of high priority. We propose to increase access to and use of shared instrumentation within the COBRE Core facilities through the purchase of a Zeiss Axio Observer 7 Live Cell Imaging system. This new live cell imaging system will support the investigators that have coalesced around the thematic focus of matrix biology. Investigators within the COBRE in Matrix Biology are diverse with respect to the primary disciplines that they represent, including biology, chemistry, physics, materials science, computer science, mechanical and biomedical engineering, and electrical engineering. Strong institutional support provided newly remodeled laboratory space and personnel to support the use through training, maintenance, and assistance for new users. The live cell imaging system will be located within new laboratory space for shared core facilities to support investigators from across campus. The enhanced core facilities will allow investigators to carry out more sophisticated experiments that address how cells respond to their environment through their extracellular matrix. Results will be disseminated through peer review publication in scientific journals and presentations at national research conferences. The acquisition of the new instrument will facilitate the achievement of our overarching goals which are to: 1) enhance and grow upon the critical mass of investigators established around the thematic multidisciplinary focus of matrix biology, 2) enhance biomedical research core capabilities, 3) grow research collaborations with existing programs, and 4) enhance research training opportunities. Upon successful completion of the proposed aims, we will have strengthened and enhanced the critical mass of investigators with shared priorities in understanding the role of the matrix in development and disease. Shared core facilities will be enhanced and will support the needs of more investigators as they follow a mentored career development plan. The multidisciplinary team science nature will continue to grow to include additional investigators across our institution.

项目摘要/摘要 基质生物学中生物医学研究中心（COBRE）的长期目标是 建立，增强和积极发展一个跨学科研究中心，重点是改善我们的 了解细胞外基质在发育，健康和疾病中的作用，并有助于 预防，治疗和治疗高优先级的疾病。我们建议增加并使用 通过购买Zeiss Axio观察者7 Live Live在Cobre核心设施内共享仪器 细胞成像系统。这个新的活细胞成像系统将支持已经合并的调查人员 围绕基质生物学的主题重点。基质生物学中的毛病中的调查人员多样化， 尊重它们所代表的主要学科，包括生物学，化学，物理学，材料科学， 计算机科学，机械和生物医学工程以及电气工程。强大的制度 支持提供了新的改建实验室空间和人员，以通过培训来支持使用， 维护和新用户的帮助。实时成像系统将位于新实验室内 共享核心设施的空间，以支持各个校园的调查人员。增强的核心设施将 允许研究人员进行更复杂的实验，以解决细胞如何对其响应 通过其细胞外基质的环境。结果将通过同行评审出版物传播 国家研究会议上的科学期刊和演讲。收购新工具 将有助于实现我们的总体目标：1）增强和发展至关重要 围绕矩阵生物学的主题跨学科重点建立的大量研究人员，2）增强 生物医学研究核心能力，3）与现有程序进行研究合作，4）增强 研究培训机会。成功完成拟议的目标后，我们将加强 并增强了研究人员在理解矩阵在 发展与疾病。共享核心设施将得到增强，并将支持更多的需求 调查人员遵循指导的职业发展计划。多学科团队科学自然 将继续增长，包括我们机构的其他调查人员。