Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)

北俄亥俄州临床和转化科学合作组织，促进健康公平的联系 (CLE Health)

基本信息

批准号：
10704417
负责人：
GRACE A MCCOMSEY
金额：
$ 807.81万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-02 至 2030-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10704417
关键词：
Academia Acceleration Address African American population Appointment Award Chronic Chronic Care Chronic Disease Cities Clinic Clinical Clinical Research Clinical Sciences Clinical Trials Collaborations Communities Data Devices Diagnostic tests Disadvantaged Discipline Disparity Dissemination and Implementation Diverse Workforce Economics Effectiveness Elderly Elements Ensure Environmental Risk Factor Equity Ethics Faculty Federally Qualified Health Center Foundations Funding Generations Goals Grant Growth HIV Health Healthy Eating Heart failure Hispanic Populations Hypertension Industry Infant Mortality Information Dissemination Institution Intervention Investments Laboratories Leadership Lesbian Gay Bisexual Transgender Queer Life Expectancy Link Medical Medical center Medicine Methods Minority Groups Mission Non-Insulin-Dependent Diabetes Mellitus Ohio Outcome Participant Patients Persons Pharmaceutical Preparations Play Population Positioning Attribute Privatization Procedures Process Public Health Public Health Informatics Rehabilitation device Research Research Personnel Resource-limited setting Resources Role Rural Safety Services Site Solid Special Population Structural Racism System Technology Testing Training Training Programs Training and Education Translation Process Translational Research Underrepresented Minority Underrepresented Populations United States Department of Veterans Affairs Universities University Hospitals Vulnerable Populations Work Workforce Development clinical practice collaborative environment community engagement community setting design disparity elimination disparity gap experience health disparity health equity health equity promotion high risk population implementation strategy improved innovation medical schools next generation novel novel strategies novel therapeutics opioid mortality point-of-care diagnostics poor health outcome primary care practice programs recruit research clinical testing rural area rural dwellers social sociocultural determinant structural determinants success translational research program translational scientist

项目摘要

PROJECT SUMMARY/ABSTRACT For the past 15 years, the Clinical and Translational Science Collaborative (CTSC) at Case Western Reserve University (CWRU) has linked clinical and translational research efforts at five independent institutions— CWRU, Cleveland Clinic, MetroHealth System, University Hospitals of Cleveland, and Louis Stokes Cleveland Veterans Affairs Medical Center. Two new partners (University of Toledo School of Medicine and Northeast Ohio Medical University) are now being added to extend the CTSC’s reach across Northern Ohio. The CWRU CTSC has a strong track record of enhancing the quantity and quality of Clinical and Translational Science (CTS) among our partners by facilitating novel research paradigms, technologies, and training. Our CTSC has developed a new generation of researchers, enhanced collaborations among investigators, streamlined discovery by building partnerships among industry and community and organizational partners, and facilitated many successful entrepreneurial startups. Building on this solid foundation, the CWRU CTSC proposes an expanded focus on health equity, reflected in the project theme Catalyzing Linkages to Equity in Health (CLE Health). Social, economic, and environmental disadvantages are linked to poor health outcomes and lead to disparities in life expectancy, infant mortality, and rates of chronic conditions. Minority groups are often underrepresented in clinical trials as well, meaning there can be insufficient data for understanding the effectiveness or safety of new drugs, procedures, or health interventions for different populations. The overall goals of this project are to 1) understand the fundamental barriers to optimal recruitment of underrepresented groups in clinical trials and test and scale interventions aimed at breaking down these barriers to diversify study engagement, 2) facilitate and expedite innovation in multicenter clinical and translational research by fully integrating community and stakeholder partners and ensuring that this research represents the experiences of all and results in health improvements for all, 3) disseminate and implement novel and responsive research programs across clinical and community settings to advance access to health interventions that aim to promote health equity, and 4) create and disseminate inclusive and high impact educational and training programs for translational research professionals of all disciplines and levels, both in clinical and community settings. The CTSC has designed a Strategic Management Core and six CTS research and training Elements to accomplish these goals: Workforce Development, Community & Stakeholder Engagement, Resources & Services, CTS Pilot, Health Informatics, and CTS Research Program. We are committed to innovative and collaborative practice and dissemination of results so that everyone in Northern Ohio—and beyond—can benefit from advances in CTS in our programs and discoveries.

项目摘要/摘要在过去的15年中，Case Western Reserve的临床和转化科学合作（CTSC）大学（CWRU）已将五个独立机构的临床和研究工作联系起来 - CWRU，克利夫兰诊所，Metrohealth系统，克利夫兰大学医院和路易斯·斯托克斯克利夫兰退伍军人事务医疗中心。两个新合作伙伴（托莱多大学医学院和东北部俄亥俄州医科大学）现在正在添加以扩展CTSC在俄亥俄州北部的范围。 CWRU CTSC在增强临床和转化科学的数量和质量方面有很强的记录（CTS）在我们的合作伙伴中，通过促进新的研究范式，技术和培训。我们的CTSC有简化了新一代研究人员，研究人员之间的合作增强了通过在工业，社区和组织合作伙伴之间建立伙伴关系并准备许多成功的创业初创公司。 CWRU CTSC的基础为基础，提案扩大对健康公平的关注，反映在项目主题中催化与健康公平的联系（CLE）健康）。社会，经济和环境灾难与健康状况不佳有关，并导致预期寿命的差异，婴儿死亡率和慢性疾病的差异。少数群体经常是在临床试验中的代表性不足，这意味着可能没有足够的数据来理解新药，程序或健康干预措施的有效性或安全性。总体该项目的目标是1）了解最佳代表性不足的基本障碍临床试验和测试和规模干预措施的小组旨在分解这些障碍以多样化研究参与，2）在多中心临床和翻译研究中促进并加快创新充分整合社区和利益相关者的伙伴，并确保这项研究代表所有人的经验以及所有人的健康改善的结果，3）传播和实施新颖和实施小说跨临床和社区环境的响应迅速研究计划，以提高健康的机会旨在促进健康公平的干预措施，以及4）创建和传播包容性和高影响力针对所有学科和级别的翻译研究专业人员的教育和培训计划，均在临床和社区环境。 CTSC设计了战略管理核心和六个CTS研究和培训要素以实现这些目标：劳动力发展，社区和利益相关者参与，资源和服务，CTS试点，健康信息学和CTS研究计划。我们是致力于创新和协作实践和结果传播，以便北部的每个人俄亥俄州以及超越我们的计划和发现中的CTS的进步。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Does rickets carry an increased risk of osteomyelitis and septic arthritis? An aggregated electronic health record data study.

佝偻病是否会增加患骨髓炎和化脓性关节炎的风险？

DOI：
10.1097/bpb.0000000000001168
发表时间：
2024
期刊：
Journal of pediatric orthopedics. Part B
影响因子：
0
作者：
Lavu,MonishS;VanDorn,Chloe;Bobak,Lukas;Burkhart,RobertJ;Kaelber,DavidC;Mistovich,RJustin
通讯作者：
Mistovich,RJustin

Prevalence of neuromyelitis optica spectrum disorder in the United States.

美国视神经脊髓炎谱系疾病的患病率。

DOI：
10.1177/13524585231224683
发表时间：
2024
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
0
作者：
Briggs,FarrenBs;Shaia,Jacqueline
通讯作者：
Shaia,Jacqueline

Pre-appendectomy hyponatremia is associated with increased rates of complicated appendicitis.

DOI：
10.1016/j.sopen.2023.05.001
发表时间：
2023-06
期刊：
SURGERY OPEN SCIENCE
影响因子：
1.4
作者：
Poston, Lauren M.;Leavitt, Tripp;Pope, Samantha;Hill, Hannah;Tollinche, Luis E.;Kaelber, David C.;Alter, Jonathan A.
通讯作者：
Alter, Jonathan A.

New-onset autoimmune disease after COVID-19.

COVID-19 后新发的自身免疫性疾病。

DOI：
10.3389/fimmu.2024.1337406
发表时间：
2024
期刊：
Frontiers in immunology
影响因子：
7.3
作者：
Hileman,CorrilynnO;Malakooti,ShahdiK;Patil,Nirav;Singer,NoraG;McComsey,GraceA
通讯作者：
McComsey,GraceA

Hands-on Fluoroscopy Safety Training for Radiology Residents: Assessment of Educational and Safety Perception Outcomes.

放射科住院医师的荧光透视安全实践培训：教育和安全感知结果评估。