Incremental effect of smoking on HIV immune activation and cardiac health

吸烟对艾滋病毒免疫激活和心脏健康的增量影响

基本信息

批准号：
8915891
负责人：
GRACE A MCCOMSEY
金额：
$ 78.84万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-15 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8915891
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Affect Age Attenuated Back Bacteria Behavior Therapy Blood Vessels CD4 Lymphocyte Count Cardiac Cardiovascular Diseases Cardiovascular system Centers for Disease Control and Prevention (U.S.)Clinical Comorbidity Diabetes Mellitus Disease Epidemiologic Studies Event Frequencies Funding Fusobacterium General Population HIV HIV Infections Health Heart Diseases Image Immunology Individual Inflammation Inflammatory Inflammatory Response Intervention Life Link Longitudinal Studies Lymphocyte Malignant Neoplasms Measures Mediating Mediation Metabolic Oral Oral mucous membrane structure Organism Osteoporosis Outcome Oxidative Stress Pathway interactions Persons Population Population Study Porphyromonas Reporting Research Risk Risk Reduction Smoke Smoker Smoking Smoking Status Time Translating United States National Institutes of Health antiretroviral therapy arterial stiffness cardiovascular disorder risk cardiovascular risk factor endothelial dysfunction fungus heart disease risk high risk immune activation improved indexing inflammatory marker monocyte mortality non-smoker oral bacteria oral microbiome pathogenic bacteria sex smoking cessation smoking prevalence vascular inflammation years of life lost

项目摘要

DESCRIPTION (provided by applicant): The prevalence of smoking is increased in the HIV-infected population. Active smoking is independently associated with higher risk of cardiovascular disease and other co-morbidities including malignancies and osteoporosis in HIV. However, the independent contribution of smoking to the heightened inflammation, immune activation, and cardiovascular risk remains unclear. We recently showed that smoking status is independently associated with increased levels of several inflammatory markers, and that higher inflammatory markers are associated with cardiovascular risk, diabetes and AIDS or non-AIDS clinical events in subjects receiving antiretroviral therapy. This application gathers a superb group of experts in HIV disease, vascular inflammation, immunology, vascular imaging, behavioral interventions, and oral microbiome studies to determine whether smoking status and furthermore smoking cessation, affect cardiovascular disease risk in HIV and the mediation effect of heightened inflammation, immune activation, oxidative stress and oral microbiome changes. Understanding the specific contribution of smoking to the heightened inflammation and immune activation in HIV-infected subjects on antiretroviral therapy has the potential to have a significant impact on prevention of HIV co-morbidities including cardiovascular disease.

描述（适用提供）：艾滋病毒感染人群中吸烟的患病率增加。活跃的吸烟与较高的心血管疾病风险和其他合并症有关，包括恶性肿瘤和HIV中的骨质疏松症。但是，吸烟对增强感染，免疫激活和心血管风险的独立贡献尚不清楚。我们最近表明，吸烟状况与几种炎症标志物的水平升高有关，并且较高的炎症标志物与接受抗逆转录病毒疗法的受试者中的心血管风险，糖尿病和艾滋病或非AIDS临床事件有关。 This application gathers a superb group of experts in HIV disease, vascular infection, immunology, vascular imaging, behavioral interventions, and oral microbiome studies to determine whether smoking status and Furthermore smoking cessation, affect cardiovascular disease risk in HIV and the mediation effect of heightened infection, immunoreactivation, oxidative stress and oral microbiome changes.了解吸烟对抗逆转录病毒疗法的艾滋病毒感染受试者的感染增强和免疫反应的特定贡献有可能对预防HIV合并症（包括心血管疾病）的预防产生重大影响。