BioAnalytical Chemistry Core

生物分析化学核心

基本信息

批准号：
10689683
负责人：
Changjian Feng
金额：
$ 24.42万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-25 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10689683
关键词：
Address Analytical Chemistry Binding Biological Biological Assay Chemistry Collaborations Complex Computers and Advanced Instrumentation Consultations Core Facility Data Analyses Dedications Development Discipline Disease Educational workshop Effectiveness Ensure Environmental Exposure Environmental Health Environmental Pollutants Environmental Risk Factor Environmental Science Equipment Exposure to Faculty Feasibility Studies Focus Groups Funding Genomics Goals Growth Human Resources Individual Institution Interdisciplinary Study Investigation Investments Knowledge Laboratories Laboratory Research Mass Spectrum Analysis Measurement Measures Metal exposure Metals Methodology Methods Mining Modernization Molecular Analysis National Institute of Environmental Health Sciences New Mexico Outcome Oxidative Stress Persons Population Study Price Property Research Research Design Research Infrastructure Research Personnel Research Support Resources Sampling Science Scientific Advances and Accomplishments Scientist Services Students Technical Expertise Technology Testing Time Trace metal Training Training and Education United States National Institutes of Health Universities Work Xenobiotics advanced analytics analytical method assay development catalyst cost effective design detection method environmental agent experience health science research innovation instrumentation member method development multidisciplinary novel operation outreach programs protocol development research facility response synergism tool training opportunity validation studies

项目摘要

BIOANALYTICAL CHEMISTRY CORE – PROJECT SUMMARY In the rapidly changing field of environmental health science, research needs are diverse and complex, requiring integration of sophisticated bioanalyses including the ability to identify and quantitate trace metal speciation and xenobiotic interactions with biomolecular targets. Performing these analyses requires highly trained personnel with specialized expertise and access to advanced high-end equipment, beyond what is typically available in most individual research laboratories. The BioAnalytical Chemistry Core (BACC) provides the NM-INSPIRES Center investigators with the necessary expertise and tools for a variety of modern bioanalyses. Moreover, the Core provides in-house analyses, supports innovative protocol development, and provides training to students, fellows, and faculty in the integrated applications associated with the advanced analytical instrumentation present in the facility. The Core additionally leverages access to several other existing on-campus core facilities to enable innovative biomolecular methods and provides these services at subsidized pricing. Even more important than access to the technology, the BACC provides tailored expertise to investigators to assist in the design of molecular analyses and data interpretation to optimize the utilization of valuable biological samples and resources. The facility will be managed by our Core leaders and knowledgeable staff scientists with strong complementary expertise in bioanalysis and research facility administration. The Core equipment is primarily housed in dedicated space in close proximity to most users. This centralization of resources and knowledge provides consolidated and cost-effective bioanalytical services and technical expertise to the Center members and users. The Core is organized into four units: Metals Analytical Chemistry, Oxidative Stress, Environmental Mass Spectrometry, and Advanced Genomics. These complementary components together will provide Center investigators with a continuum of bioanalytical capabilities for comprehensively characterizing the response to environmental exposures and contaminants. The Specific Aims of this Core are 1) to provide consultation in the design, execution and interpretation of studies that require the use of advanced analytical instrumentation for environmental research; 2) to develop and validate novel analytical methods for detection and quantitation of environmental species in complex samples; and 3) to provide education and training in analytical methods for environmental research through personal outreach, courses and workshops, enabling the integration of cutting-edge analytical technologies into the research of NM-INSPIRES members. Overall, the BioAnalytical Chemistry Core will add considerable value to environmental health research at the University of New Mexico by leveraging existing institutional and NIH investments in research infrastructure to achieve the goals of our NM-INSPIRES research team.

生物分析化学核心——项目摘要在快速变化的环境健康科学领域，研究需求多样化且复杂，需要集成复杂的生物分析，包括识别和定量痕量金属的能力进行这些分析需要高度的分析。训练有素的人员拥有专业知识并能够使用先进的高端设备，超出了现有的水平大多数个人研究实验室通常都提供生物分析化学核心 (BACC)。为 NM-INSPIRES 中心研究人员提供各种现代研究所需的专业知识和工具此外，核心提供内部分析，支持创新方案开发，以及为学生、研究员和教师提供与高级相关的集成应用程序的培训设施中的分析仪器还利用了其他几个仪器。现有的校园核心设施，以实现创新的生物分子方法，并在以下地点提供这些服务：比获得技术更重要的是，BACC 提供量身定制的专业知识。为研究人员提供协助设计分子分析和数据解释以优化利用该设施将由我们的核心领导者和资源管理。知识渊博的科学家在生物分析和研究设施方面具有强大的互补专业知识核心设备主要放置在靠近大多数用户的专用空间中。这种资源和知识的集中提供了综合且具有成本效益的生物分析服务中心成员和用户的技术专业知识分为四个单元：金属。分析化学、氧化应激、环境质谱和高级基因组学。互补的组件一起将为中心研究人员提供连续的生物分析全面表征对环境暴露和污染物的响应的能力。该核心的具体目标是 1) 提供设计、执行和解释方面的咨询 2) 需要使用先进分析仪器进行环境研究的研究；并验证复杂环境物种检测和定量的新分析方法样品；3) 通过以下方式提供环境研究分析方法的教育和培训：个人推广、课程和研讨会，实现尖端分析技术的整合总体而言，生物分析化学核心将增加相当多的内容。通过利用现有机构和技术，新墨西哥大学环境健康研究的价值 NIH 对研究基础设施的投资是为了实现我们 NM-INSPIRES 研究团队的目标。