Integrative Molecular Analysis Core

综合分子分析核心

• 批准号: 10202649
• 负责人: Changjian Feng
• 金额: $ 56.5万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10202649
• 关键词: Analytical Chemistry; Area; Biochemistry; Biological; Biology; Biomedical Research; Cancer Biology; Cells; Centers of Research Excellence; Collaborations; Communities; Complex; Computers and Advanced Instrumentation; Consultations; Core Facility; Data Analyses; Development; Disease; Educational workshop; Ensure; Environmental Health; Equipment; Faculty; Fostering; Funding; Goals; Growth; Health Sciences; Human Resources; Individual; Inductively Coupled Plasma Mass Spectrometry; Institutes; Interdisciplinary Study; Investigation; Knowledge; Laboratory Research; Leadership; Mass Spectrum Analysis; Mediating; Medicine; Mentors; Metals; Methodology; Methods; Modernization; Molecular; Molecular Analysis; New Mexico; Nutrient; Outcome; Oxidative Stress; Price; Productivity; Reproducibility; Research; Research Personnel; Research Support; Research Training; Resources; Sampling; Schedule; Science; Scientist; Services; Specialist; Spin Trapping; Structure; Students; Technical Expertise; Technology; Trace metal; Training; United States National Institutes of Health; Universities; Vision; Work; advanced analytics; base; biological systems; cohort; cost effective; design; improved; in vivo; innovation; instrumentation; knowledge base; member; multidisciplinary; novel; novel therapeutics; outreach; programs; protocol development; public health relevance; research facility; synergism; tool; training opportunity; web page

INTEGRATIVE MOLECULAR ANALYSIS CORE – PROJECT SUMMARY In the rapidly changing field of Metals in Biology and Medicine, research needs are diverse and complex. Currently, advances in inorganic biochemistry – and its application to biomedical phenomena – require sophisticated integration of molecular analyses, including the ability to identify and quantitate trace metal speciation and metal interactions with biomolecular targets. These analyses require highly trained personnel with specialized expertise and access to advanced high-end equipment, beyond what is typically available in most individual research laboratories. The Integrative Molecular Analysis Core (IMAC) provides the UNM Center for Metals in Biology and Medicine investigators with the necessary expertise and tools for a variety of modern molecular analyses, including ICP-MS, EPR spin-trapping, and quantitative mass spectrometry. Moreover, the Core provides in-house analyses, supports innovative protocol development, and provides training to students, fellows, and faculty in the integrated applications associated with the advanced analytical instrumentation present in the IMAC facility. The Core additionally leverages access to several other existing on-campus core facilities to enable innovative biomolecular methods, and provides these services at subsidized pricing. Even more important than access to the technology, the IMAC provides tailored expertise to investigators to assist in the design of molecular analyses and data interpretation, to optimize use of valuable biological samples and resources. The facility will be managed by a cadre of specialists with strong complementary expertise in molecular analysis, research facility administration, training, and mentoring of junior faculty. The Core equipment is primarily housed in dedicated space in close proximity to most users. This centralization of resources and knowledge provides consolidated and cost-effective analytical services and technical expertise to the Center members and users. The Core is organized in three units: Metals Analytical Chemistry, Oxidative Stress, and Biological Mass Spectrometry. The Specific Aims of this Core are: 1) to create a centralized, state-of-the-art resource that provides expertise, training and instrumentation for integrative molecular analysis, focused on metal interactions with biological systems; 2) to support the research objectives of mentored PIs and cultivate a new cohort of COBRE investigators within the Center for Metals in Biology and Medicine; and 3) develop a user base of established, funded investigators for continued growth and sustainability of the core facility. The expected outcomes include enhanced multidisciplinary research capabilities that support metals programs of mentored PIs in their trajectory toward R01 level funding, and increased collaborations within UNM, and across New Mexico and other IDeA states. These outcomes will positively impact the level of research excellence at UNM and enhance investigations into novel therapeutics for metal-mediated diseases that afflict millions of people in New Mexico and worldwide.

综合分子分析核心 - 项目摘要 在生物学和医学中金属快速变化的领域中，研究需求是潜水员和复杂的。 目前，无机生物化学的进步及其在生物医学现象中的应用都需要 分子分析的复杂整合，包括识别和定量痕量金属的能力 规格和金属与生物分子靶标的相互作用。这些分析需要训练有素的人员 具有专业知识并可以使用高级高端设备，超出了通常可用的 大多数个人研究实验室。综合分子分析核心（IMAC）提供了UNM 生物学和医学研究人员中心具有必要的专业知识和工具 现代分子分析，包括ICP-MS，EPR旋转捕获和定量质谱。 此外，核心提供内部分析，支持创新协议开发并提供 在与高级分析相关的集成申请中对学生，研究员和教师进行培训 iMac设施中存在的仪器。核心还利用其他几个现有的访问权限 校园内核心设施可以实现创新的生物分子方法，并在 补贴定价。 iMac比对技术的访问更重要，它为 研究人员协助设计分子分析和数据解释，以优化价值的使用 生物样品和资源。该设施将由拥有强大专家的干部管理 在分子分析，研究设施管理，培训和心理方面的完全专业知识 初级教师。核心设备主要在专用空间中靠近大多数用户。 资源和知识的集中化提供了合并且具有成本效益的分析服务 和中心成员和用户的技术专业知识。核心分为三个单位：金属 分析化学，氧化应激和生物质谱法。该核心的具体目的是： 1）创建一个集中的，最先进的资源，以提供专业知识，培训和工具 集成分子分析，重点是与生物系统的金属相互作用； 2）支持 指导PI的研究目标，并在该中心培养了一批新组的山地杂货调查员 生物学和医学的金属； 3）建立一个已建立的，资助的调查人员的用户群以持续 核心设施的增长和可持续性。预期的结果包括增强的多学科 支持Metals计划的研究能力，以修改PI的轨迹，用于R01级资助， 并增加了UNM内部以及新墨西哥州和其他思想状态的合作。这些结果会 积极影响UNM研究的卓越研究水平，并增强对新疗法的研究 对于金属介导的疾病，在新墨西哥州和全球范围内遭受了数百万人的疾病。