Integrative Molecular Analysis Core

综合分子分析核心

基本信息

批准号：
10408029
负责人：
Changjian Feng
金额：
$ 56.06万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10408029
关键词：
Analytical Chemistry Area Biochemistry Biological Biology Biomedical Research Cancer Biology Cells Centers of Research Excellence Collaborations Communities Complex Computers and Advanced Instrumentation Consultations Core Facility Data Analyses Development Disease Educational workshop Ensure Environmental Health Equipment Faculty Fostering Funding Goals Growth Health Sciences Human Resources Individual Inductively Coupled Plasma Mass Spectrometry Institutes Interdisciplinary Study Investigation Knowledge Laboratory Research Leadership Mass Spectrum Analysis Mediating Medicine Mentors Metals Methodology Methods Modernization Molecular Molecular Analysis New Mexico Nutrient Outcome Oxidative Stress Persons Price Productivity Reproducibility Research Research Personnel Research Support Research Training Resources Sampling Schedule Science Scientist Services Specialist Spin Trapping Strategic vision Structure Students Technical Expertise Technology Trace metal Training United States National Institutes of Health Universities Work advanced analytics base biological systems cohort cost effective design improved in vivo innovation instrumentation knowledge base member multidisciplinary novel novel therapeutics outreach programs protocol development public health relevance research facility synergism tool training opportunity web page

项目摘要

INTEGRATIVE MOLECULAR ANALYSIS CORE – PROJECT SUMMARY In the rapidly changing field of Metals in Biology and Medicine, research needs are diverse and complex. Currently, advances in inorganic biochemistry – and its application to biomedical phenomena – require sophisticated integration of molecular analyses, including the ability to identify and quantitate trace metal speciation and metal interactions with biomolecular targets. These analyses require highly trained personnel with specialized expertise and access to advanced high-end equipment, beyond what is typically available in most individual research laboratories. The Integrative Molecular Analysis Core (IMAC) provides the UNM Center for Metals in Biology and Medicine investigators with the necessary expertise and tools for a variety of modern molecular analyses, including ICP-MS, EPR spin-trapping, and quantitative mass spectrometry. Moreover, the Core provides in-house analyses, supports innovative protocol development, and provides training to students, fellows, and faculty in the integrated applications associated with the advanced analytical instrumentation present in the IMAC facility. The Core additionally leverages access to several other existing on-campus core facilities to enable innovative biomolecular methods, and provides these services at subsidized pricing. Even more important than access to the technology, the IMAC provides tailored expertise to investigators to assist in the design of molecular analyses and data interpretation, to optimize use of valuable biological samples and resources. The facility will be managed by a cadre of specialists with strong complementary expertise in molecular analysis, research facility administration, training, and mentoring of junior faculty. The Core equipment is primarily housed in dedicated space in close proximity to most users. This centralization of resources and knowledge provides consolidated and cost-effective analytical services and technical expertise to the Center members and users. The Core is organized in three units: Metals Analytical Chemistry, Oxidative Stress, and Biological Mass Spectrometry. The Specific Aims of this Core are: 1) to create a centralized, state-of-the-art resource that provides expertise, training and instrumentation for integrative molecular analysis, focused on metal interactions with biological systems; 2) to support the research objectives of mentored PIs and cultivate a new cohort of COBRE investigators within the Center for Metals in Biology and Medicine; and 3) develop a user base of established, funded investigators for continued growth and sustainability of the core facility. The expected outcomes include enhanced multidisciplinary research capabilities that support metals programs of mentored PIs in their trajectory toward R01 level funding, and increased collaborations within UNM, and across New Mexico and other IDeA states. These outcomes will positively impact the level of research excellence at UNM and enhance investigations into novel therapeutics for metal-mediated diseases that afflict millions of people in New Mexico and worldwide.

综合分子分析核心——项目摘要在生物和医学金属快速变化的领域，研究需求多种多样且复杂。目前，无机生物化学的进展及其在生物医学现象中的应用需要分子分析的复杂集成，包括识别和定量痕量金属的能力这些分析需要训练有素的人员。拥有专业知识和先进的高端设备，超出了通常可用的范围大多数个体研究实验室都提供综合分子分析核心 (IMAC)。生物学和医学金属研究中心的研究人员拥有各种必要的专业知识和工具现代分子分析，包括 ICP-MS、EPR 自旋捕获和定量质谱分析。此外，核心提供内部分析，支持创新协议开发，并提供为学生、研究员和教师提供与高级分析相关的综合应用培训 IMAC 设施中存在的仪器还利用了对其他几个现有设施的访问。校园核心设施，以实现创新的生物分子方法，并提供这些服务比获得技术更重要的是，IMAC 提供量身定制的专业知识。研究人员协助分子分析和数据解释的设计，以优化有价值的利用该设施将由一支实力雄厚的专家队伍管理。分子分析、研究设施管理、培训和指导方面的互补专业知识核心设备主要放置在靠近大多数用户的专用空间中。这种资源和知识的集中提供了综合且具有成本效益的分析服务中心成员和用户的技术专业知识由三个部门组成：金属。分析化学、氧化应激和生物质谱该核心的具体目标是： 1) 创建一个集中的、最先进的资源，为以下人员提供专业知识、培训和仪器综合分子分析，重点关注金属与生物系统的相互作用；2) 支持指导 PI 的研究目标，并在中心培养一批新的 COBRE 研究人员生物学和医学中的金属；3) 发展已建立的、受资助的研究人员的用户群，以供持续使用核心设施的增长和可持续性的预期成果包括增强的多学科性。支持受指导 PI 的金属项目走向 R01 级资助的研究能力，并加强新墨西哥州内部以及新墨西哥州和其他 IDeA 州的合作。这些成果将实现。积极影响新墨西哥大学的卓越研究水平并加强对新疗法的研究治疗影响新墨西哥州和全世界数百万人的金属介导疾病。