National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA): San Diego Research Project Site

国家酒精与青春期神经发育联盟 (NCANDA)：圣地亚哥研究项目网站

基本信息

批准号：
10677631
负责人：
SUSAN F TAPERT
金额：
$ 79.96万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10677631
关键词：
21 year old Abstinence Acceleration Acute Adolescence Adolescent Adult Adverse effects Affect Affective Age Alcohol abuse Alcohol consumption Alcohols Behavioral Biological Brain COVID-19 pandemic COVID-19 pandemic effects Clinical Cognition Cognitive Communities Complement Computers Data Development Distress Dose Economics Elements Emotional Event Family Female Frequencies Functional Magnetic Resonance Imaging Goals Growth Health Heart Rate Heavy Drinking Home Impairment Individual Learning Life Life Stress Link Longitudinal Studies Machine Learning Magnetic Resonance Imaging Measures Mediating Memory Mission Modeling Monitor Outcome Outcome Measure Patient Recruitments Pattern Personal Satisfaction Persons Physical activity Polysomnography Positioning Attribute Process Protocols documentation Psychopathology Psychosocial Factor Quality of life Recording of previous events Recovery Research Project Grants Rest Risk Risk Factors Sampling Schools Sex Differences Sex Differentiation Site Sleep Sleep disturbances Specific qualifier value Stress Structure Symptoms System Technology Testing Work adolescent binge drinking alcohol cue alcohol effect alcohol expectancy alcohol use disorder alcohol use initiation binge drinking cognitive control cognitive performance cohort cue reactivity design drinking drinking onset early onset emerging adult emerging adulthood experience externalizing behavior follow-up gray matter heart function improved information processing male medical specialties mobile application modifiable risk multimodal neuroimaging neural neurodevelopment neuroimaging neuropsychiatry novel pandemic disease post-pandemic pre-pandemic recruit response retention rate social underage drinking

项目摘要

PROJECT SUMMARY Initiating excessive alcohol drinking during adolescence is known to disturb typical neurodevelopmental patterns, increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood. In response to RFA-AA-21-007, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a diverse community sample of male and female participants recruited in three age bands (12-14, 15-17, 18-21 years old) when most were no-to-low drinkers and tracked over the last 8 years across 5 sites (N=831; 93% retention rate). Monitoring has involved annually acquired multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep and physical activity tracking. This cohort sequential design uniquely positions NCANDA-A to quantify transient or enduring alcohol-related disturbances in specific adolescent and early adult neural system growth trajectories and functional concomitants. NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, NCANDA-A will investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on subsequent developmental trajectories of cognitive performance, brain structure and function, and psychopathology. Aim 2 analyses will identify neurodevelopment patterns describing the extent to which alcohol’s effects on brain structure and function resolve or persist during desistance after binge drinking. Aim 3 will deploy data-driven analysis to identify adolescent biological, environmental, and behavioral factors (e.g., age of drinking onset) that forecast excessive drinking during early adulthood. In Aim 4, NCANDA-A will quantify the impact of the COVID pandemic on life stress and social, emotional, and economic wellbeing and their relations with alcohol use patterns. In Aim 5, the SRI and Pittsburgh sites will identify interactions among patterns of alcohol use, sleep, and cardiac function. In Aim 6, the UCSD, Duke and OHSU sites will determine the extent to which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect, sleep and resting heart rate, and reversal of the adverse structural and functional brain effects of frequent binge alcohol use. For each aim, sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors will be tested. With the longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel information to the public on the enduring and transient effects of adolescent drinking on adult functioning by discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.

项目摘要众所周知，在青少年期间开始过量饮酒会干扰典型的神经发育模式，增加患者使用饮酒障碍（AUD）的风险，并在成年期加速递送过程。为了回应RFA-AA-21-007，该申请提出了国家财团的研究项目网站关于青少年的酒精和神经发育 - 成年（NCANDA -A）接下来的5年在三个年龄乐队中招募的男性和女性参与者的潜水员社区样本（12-14、15-17、18-21 过去的8年中，大多数人都不是低饮酒者并在5个网站上进行了追踪（n = 831; 93％保留率）。监测涉及每年获得的多模式神经影像学（MRI，DTI，静止状态 fMRI，fMRI），认知，临床，行为和生物学数据，亲自收集或通过计算机收集和我们的移动应用程序。这些措施现在将通过新的高级神经影像和睡眠来完成和体育活动跟踪。该队列顺序设计独特地定位了NCANDA-A以量化瞬态或在特定青少年和早期成人神经元系统生长轨迹中持续与酒精相关的疾病和功能伴随。 NCANDA-A提案四个联盟整个特定的目标和两个专业项目的目标。在AIM 1，Ncanda-A 将调查青少年和成年期间过量饮酒的影响随后的认知性能，大脑结构和功能的发展轨迹以及心理病理学。 AIM 2分析将确定神经发育模式，描述酒精对大脑结构和功能的影响在暴饮暴食后解决或持续存在。目标3 将部署数据驱动分析以识别青少年生物学，环境和行为因素（例如，年龄饮酒的发作）预测成年初期过高的饮酒。在AIM 4中，Ncanda-A将量化共同大流行对生活压力，社会，情感和经济福祉及其关系的影响与酒精使用模式。在AIM 5中，SRI和匹兹堡站点将确定饮酒，睡眠和心脏功能。在AIM 6中，UCSD，Duke和OHSU站点将确定哪种短期（即4周）饮酒停用导致认知的急性改善，影响，睡眠和静息心率，以及经常暴饮暴食的不良结构和功能性大脑影响饮酒。对于每个目标，性别差异，饮酒方式和历史，酒精的影响将测试在大脑上使用，并分配性别差异的社会心理因素。随着纵向数据在此续签期间收集到成年早期，Ncanda-A将提供新颖的向公众提供有关青少年饮酒对成人功能的持久和短暂影响的信息发现连接这些动态过程并识别可修改风险因素的元素和机制。

项目成果

期刊论文数量（42）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Altered Brain Developmental Trajectories in Adolescents After Initiating Drinking.

DOI：
10.1176/appi.ajp.2017.17040469
发表时间：
2018-04-01
期刊：
The American journal of psychiatry
影响因子：
0
作者：
Pfefferbaum A;Kwon D;Brumback T;Thompson WK;Cummins K;Tapert SF;Brown SA;Colrain IM;Baker FC;Prouty D;De Bellis MD;Clark DB;Nagel BJ;Chu W;Park SH;Pohl KM;Sullivan EV
通讯作者：
Sullivan EV

Alcohol and the Adolescent Brain: What We've Learned and Where the Data Are Taking Us.

DOI：
10.35946/arcr.v42.1.07
发表时间：
2022
期刊：
Alcohol research : current reviews
影响因子：
0
作者：
Tapert SF;Eberson-Shumate S
通讯作者：
Eberson-Shumate S

Neuroimaging markers of adolescent depression in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study.

DOI：
10.1016/j.jad.2021.03.071
发表时间：
2021-05-15
期刊：
Journal of affective disorders
影响因子：
6.6
作者：
Meruelo AD;Brumback T;Nagel BJ;Baker FC;Brown SA;Tapert SF
通讯作者：
Tapert SF

Effects of prior testing lasting a full year in NCANDA adolescents: Contributions from age, sex, socioeconomic status, ethnicity, site, family history of alcohol or drug abuse, and baseline performance.

先前测试对 NCANDA 青少年持续一整年的影响：年龄、性别、社会经济地位、种族、地点、酗酒或吸毒家族史以及基线表现的影响。

DOI：
10.1016/j.dcn.2017.01.003
发表时间：
2017
期刊：
Developmental cognitive neuroscience
影响因子：
4.7
作者：
Sullivan,EdithV;Brumback,Ty;Tapert,SusanF;Prouty,Devin;Fama,Rosemary;Thompson,WesleyK;Brown,SandraA;Cummins,Kevin;Colrain,IanM;Baker,FionaC;Clark,DuncanB;Chung,Tammy;DeBellis,MichaelD;Hooper,StephenR;Nagel,BonnieJ;
通讯作者：

Adverse Childhood Experiences and Binge Drinking in Adolescence: the Role of Impulsivity and PTSD Symptoms.

不良童年经历和青春期酗酒：冲动和创伤后应激障碍症状的作用。