National Consortium on Alcohol and NeuroDevelopment in Adolescence: San Diego

国家青少年酒精与神经发育联盟：圣地亚哥

基本信息

批准号：
8537346
负责人：
SUSAN F TAPERT
金额：
$ 68.33万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8537346
关键词：
Abstinence Address Adolescence Adolescent Adult Advanced Development Adverse effects Affect Affective Age Alcohol consumption Alcohol or Other Drugs use Alcoholic Intoxication Alcoholic beverage heavy drinker Alcoholism Alcohols Anatomy Area Behavioral Brain Brain imaging California Characteristics Childhood Clinical assessments Cognitive Communities Conflict (Psychology)DNA Data Development Diagnostic Diffusion Magnetic Resonance Imaging Dose Drug usage Family history of Functional Magnetic Resonance Imaging Future Goals Heavy Drinking Human Imaging Techniques International Longitudinal Studies Magnetic Resonance Imaging Measures Mediating Mental Health Midbrain structure Monitor Neurobiology Neurocognitive Neuropsychological Tests Outcome Parietal Pattern Performance Population Prevention Process Protocols documentation Psychopathology Recovery Recruitment Activity Regulation Reporting Research Resolution Rest Rewards Risk Risk Factors Role Sampling Site Sleep Stages Substance Use Disorder System Teenagers Universities Visit Youth adolescent alcohol alcohol abstinence alcohol and other drug alcohol consequences alcohol effect alcohol exposure alcohol involvement alcohol use disorder base disorder risk drinking follow-up genetic analysis heavy drinking during adolescence high risk longitudinal design medical specialties neurodevelopment neuroimaging neuropsychological neurotoxic psychobiologic psychologic relating to nervous system response sex twelfth grade underage drinking white matter young adult

项目摘要

DESCRIPTION (provided by applicant): In response to RFA-AA-12-006, this application proposes the UCSD Research Component of the National Consortium on Alcohol and Neurodevelopment in Adolescence (N-CANDA) to determine the effects of alcohol use on the developing adolescent brain. Recruited at ages 12 through 21, a high risk enhanced community sample of 170 San Diego subjects (N=680 from all 4 sites) will complete a baseline assessment and undergo three annual follow-up assessments in an accelerated longitudinal design. At each visit, a multimodal magnetic resonance imaging (MRI) protocol, comprehensive neuropsychological battery, and assessments of alcohol and other substance use and related problems, mental health symptomatology, and substance use disorder risk factors will be measured. Brain imaging includes state-of-the-art high-resolution structural MRI (sMRI), diffusion tensor imaging (DTI), and resting state MRI (rsMRI). The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, our Research Component will collaborate on two additional studies. First, we will collaborate with the Duke University site to study recovery of these abnormalities. Specifically, we will examine the degree to which targeted heavy drinking related neurocognitive and brain integrity deficits remit over 4 weeks of monitored abstinence. Second, we will collaborate with the SRI International site to study the default mode network. In particular, we will examine the influence of adolescent heavy drinking on default mode network integrity, and the extent to which this mediates cognitive performance, using functional connectivity analyses during a Stroop Match to Sample task in conjunction with resting state fMRI data acquired both before and after the task. Studied in the context of risks and baseline brain characteristics, we will determine both the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent at elevated risk for an alcohol use disorder.

描述（由申请人提供）：为了响应RFA-AA-12-006，本申请提出了国家酒精和神经发育联盟的UCSD研究成分（N-CANDA），以确定酒精使用对发展青少年大脑的影响。在12至21岁时招募，高风险增强了170名圣地亚哥受试者的社区样本（来自所有4个地点的n = 680）将完成基线评估，并在加速的纵向设计中接受3个年度随访评估。每次访问时，将测量多模式磁共振成像（MRI）方案，全面的神经心理电池以及对酒精和其他药物使用以及相关问题的评估，心理健康症状和使用物质使用障碍风险因素。脑成像包括最先进的高分辨率结构MRI（SMRI），扩散张量成像（DTI）和静止状态MRI（RSMRI）。对酒精后果的检查将集中于在青春期积极发展的大脑区域的结构和功能成熟，参与了心理调节，对奖励做出反应，并且似乎容易受到酒精的神经毒性影响。此外，我们的研究部分将在另外两项研究中进行合作。首先，我们将与杜克大学网站合作研究这些异常的恢复。具体而言，我们将研究针对重量饮酒相关的神经认知和大脑完整性缺陷的程度，该程度在4周的受监测节制中引起了累积。其次，我们将与SRI国际网站合作研究默认模式网络。特别是，我们将研究青少年重饮酒对默认模式网络完整性的影响，以及在Stroop匹配期间使用功能连通性分析与静止状态fMRI数据在任务之前和之后获得的静止状态fMRI数据，从而介导认知性能的程度。在风险和基线大脑特征的背景下进行了研究，我们将确定酒精暴露对青春期人脑发育轨迹的影响，并确定先前存在的心理生物学脆弱性，这些脆弱性可能使青少年处于酒精使用障碍的风险较高。