Development of a mobile health intervention for electronic cigarette use among young adults

开发针对年轻人电子烟使用的移动健康干预措施

基本信息

批准号：
10449656
负责人：
Emma Brett
金额：
$ 17.28万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10449656
关键词：
Abstinence Address Adolescence Adverse effects Affect Area Behavior Behavioral Biochemical Cigarette Clinical Cognitive Data Dependence Development Devices Drops Education Effectiveness Electronic Nicotine Delivery Systems Electronic cigarette Feedback Focus Groups Frequencies Funding Health Immersion Individual Intervention Lead Literature Marijuana Mentors Mentorship Modality Motivation Nicotine Dependence Outcome Participant Pattern Pharmacotherapy Phase Pilot Projects Population Prevalence Randomized Randomized Controlled Trials Reporting Research Research Personnel Resources Running Safety Sampling Schedule Scientist Smoking Smoking Cessation Intervention Text Messaging Therapeutic Intervention Time Tobacco Tobacco use Training Translations Update Work Youth acceptability and feasibility addiction addiction liability base behavior change cancer risk career cigarette smoking cigarette user combustible cigarette comparison intervention cost effective intervention effective therapy effectiveness evaluation electronic cigarette use epidemiologic data evidence base experience follow up assessment follow-up interest intervention effect mHealth new technology nicotine replacement nicotine use novel prevent primary outcome programs randomized trial recruit secondary outcome skills smoking cessation standard care substance use text messaging intervention therapy development tobacco control tobacco products tobacco user uptake vaping web site young adult

项目摘要

PROJECT ABSTRACT Despite declines in combustible cigarette smoking among young adults, use of electronic nicotine delivery systems (ENDS), such as e-cigarettes, continues to rise. Young adulthood marks a particularly susceptible time for the experimentation and initiation of substance use behaviors, including tobacco. Further, some who initiate tobacco use with ENDS transition to combustible products, such as cigarettes or marijuana, or become users of multiple products (dual/poly users). Despite the addiction potential of ENDS and high interest in quitting among young adults , there are few resources available to help individuals quit or reduce their use of ENDS. The aim of the proposed research is to develop an evidence-based mobile health (mHealth) text- message based intervention for young adult ENDS and dual (ENDS and cigarette) users (K99 phase 1), and determine whether the intervention is effective in reducing ENDS use (primary outcome) and increasing cessation , quit attempts, and use of nicotine replacement therapy (NRT; secondary outcomes; R00 phase 2). In phase 1 (K99), we will determine intervention content and delivery schedule based on existing evidence- based smoking cessation materials as well as utilize focus groups with young adult ENDS users (both ENDS- only and dual users) to adapt content to an mHealth ENDS-specific intervention. We will then run an initial pilot study with 45 participants to determine intervention feasibility and acceptability. After the pilot intervention, we will conduct additional focus groups with individuals who participated in the pilot to further refine the intervention. In phase 2 (R00), we will conduct a randomized control trial to determine the intervention’s effect on ENDS outcomes. Young adult ENDS and dual users will be randomized to one of three conditions: 1) mHealth ENDS intervention, 2) standard ENDS advice+NRT, or 3) standard advice alone . Standard advice will include a website that will be updated with information on products/safety and strategies for ENDS cessation as information evolves over the course of the study. Participants in the mHealth condition will complete a 6- week text-message based intervention with content tailored based on 1) motivation to quit ENDS, 2) whether an individual uses ENDS only or is a dual user of tobacco products, and 3) target quit date. Participants will complete an assessment of ENDS behaviors, quit attempts, and use of NRT at 3-month follow-up. ENDS use frequency will be the primary outcome , while biochemically verified 7-day point prevalence abstinence, NRT use, and quit attempts will be the secondary outcomes of interest. This study’s findings will inform emerging ENDS intervention literature, an area where a clear evidence base is currently lacking, and whether a mHealth intervention can impact young adults’ ENDS cessation, behaviors, and barriers to NRT use. This project will serve to provide valuable mentorship and training complementary to the proposed research to facilitate Dr. Brett’s transition to an independently-funded investigator and clinical addiction and tobacco control scientist.

项目摘要尽管年轻人吸可燃香烟的人数有所下降，但使用电子尼古丁传送电子烟等电子烟系统（ENDS）持续上升，标志着青少年特别容易受到影响。尝试和开始物质使用行为（包括烟草）的时间。开始使用烟草，并过渡到可燃产品，例如香烟或大麻，或者成为尽管电子尼古丁传送系统具有成瘾性，但同时使用多种产品的用户（双重/多重用户）。以及高度的兴趣年轻人戒烟，可用于帮助个人戒烟的资源很少或减少他们的使用拟议研究的目的是开发一种基于证据的移动健康（mHealth）文本- 针对年轻成人电子尼古丁传送系统和双重（电子尼古丁传送系统和香烟）使用者的基于信息的干预（K99 第 1 阶段），以及确定干预措施是否有效减少电子尼古丁传送系统的使用（主要成果）并增加停止、戒烟尝试以及使用尼古丁替代疗法（NRT；次要结果；R00 第 2 期）。在第一阶段（K99），我们将根据现有证据确定干预内容和实施时间表- 基于戒烟材料以及利用年轻成年电子尼古丁传送系统使用者（电子尼古丁传送系统-电子尼古丁传送系统）的焦点小组仅限和双重用户）以使内容适应 mHealth ENDS 特定干预措施，然后我们将进行初步试点。与学习 45 试点干预后，我们确定参与者的干预可行性和可接受性。将与参与试点的个人进行额外的焦点小组讨论，以进一步完善在第二阶段（R00），我们将进行随机对照试验以确定干预的效果。青少年 ENDS 和双重使用者将被随机分配到其中一项。三条件：1）移动医疗结束干预， 2) 标准 ENDS 建议+NRT，或 3) 单独标准建议 .标准建议将包括一个网站，该网站将更新有关产品/安全的信息以及电子尼古丁传送系统停止策略的信息随着研究过程中信息的发展，移动医疗条件的参与者将完成 6- 每周基于短信的干预，其内容根据 1) 戒烟动机ENDS，2) 是否个人仅使用 ENDS 或是烟草制品的双重使用者，并且 3) 参与者的目标戒烟日期。在 3 个月的随访中完成对 ENDS 行为、戒烟尝试和 NRT 使用的评估。使用频率将是主要结果，而生化验证的 7 天点流行率戒断、NRT 使用和戒烟尝试将是次要的结果，这项研究的结果将为新兴市场提供信息。 ENDS 干预文献，目前缺乏明确证据基础的领域，以及移动医疗是否干预可能会影响年轻人的 ENDS 戒断、行为以及 NRT 使用障碍。旨在提供宝贵的指导和培训，以补充拟议的研究，以促进博士。布雷特转变为一名独立资助的调查员以及临床成瘾和烟草控制科学家。